Solifenacin succinate - 10mM in Water , Muscarinic acetylcholine receptor M2 antagonist, CAS No.242478-38-2, Muscarinic acetylcholine receptor M2 antagonist

CAS: 242478-38-2 Cat. No.: S408550 Formula: C₂₃H₂₆N₂O·C₄H₆O₄ Molecular Weight: 480.55 EC Number: 620-505-5 PubChem CID: 216457

GRADE & PURITY 10mM in Water

Synonyms

YM905 | Butanedioic acid, compd. with (1S)-(3R)-1-azabicyclo[2.2.2]oct-3-yl 3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate (1:1)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Solifenacin succinate (YM905) is a urinary antispasmodic of the antimuscarinic class.
In vitro

Solifenacin succinate is a new muscarinic receptor antagonist developed for the treatment of overactive bladder. The affinity constants (pKi) of solifenacin for recombinant human muscarinic M1, M2 and M3 receptors are 7.6, 6.9 and 8.0, respectively. Hence, the muscarinic M3 receptor subtype selectivity of solifenacin over the muscarinic M2 receptor subtype is readily apparent, but is only marginal over the muscarinic M1 receptor subtype. In the same study, solifenacin and oxybutynin inhibit muscarinic M3 receptor-mediated intracellular Ca2+ mobilization in bladder smooth muscle cells isolated from guinea pigs and in submandibular gland cells isolated from mice.

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

YM905 | Butanedioic acid, compd. with (1S)-(3R)-1-azabicyclo[2.2.2]oct-3-yl 3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate (1:1)

Specifications & Purity

10mM in Water

Biochemical and Physiological Mechanisms

Solifenacin succinate (YM905) is a urinary antispasmodic of the antimuscarinic class.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

ANTAGONIST

Mechanism of action

Muscarinic acetylcholine receptor M2 antagonist

Names and Identifiers

Isomeric SMILES

C1CN2CCC1[C@H](C2)OC(=O)N3CCC4=CC=CC=C4[C@@H]3C5=CC=CC=C5.C(CC(=O)O)C(=O)O

PubChem CID

216457

Molecular Weight

480.55

Associated Targets(Human)

CHRM1 Tclin Muscarinic acetylcholine receptor M1 (1 Activities)

Discover Target: CHRM1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro DMSO: 59 mg/mL (197.5 mM); Water: 59 mg/mL (197.5 mM); Ethanol: Insoluble
• Melt Point(°C): 147 °C