SQ 28517 , CAS No.92131-67-4

CAS: 92131-67-4 Cat. No.: S1455459 Formula: C₃₆H₅₆N₁₂O₁₄S Molecular Weight: 912.97

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

SQ 28517 is an active compound.

Specifications

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

Molecular Weight

912.97

Application Protocols

Validated application data are not provided for SQ 28517.

• Tested applications (e.g., WB, IF, IHC, enzymatic assays): Not specified for this item; refer to CoA/Spec Sheet.
• Recommended working concentrations/dilutions: Not specified for this item; refer to CoA/Spec Sheet.

General protocol framework for small-molecule tool use

• Stock preparation: Dissolve in DMSO (or suitable solvent identified by screening). Filter-sterilize if aseptic conditions are required.
• Dose preparation: Serially dilute into assay buffer/media; maintain constant vehicle percentage across conditions.
• Controls: Include vehicle-only and, where available, a known reference compound.
• Documentation: Record lot number, stock concentration, final solvent %, incubation time and temperature, and assay readout method.

Biological Roles

No biological target, pathway, or mechanism of action is provided for SQ 28517 in the product data.

• Target, binding class, and pathway: Not specified for this item; refer to CoA/Spec Sheet or primary literature associated with the CAS if available.
• Typical use-case for life-science small molecules (general): probe modulation of enzymatic activity, receptor signaling, transport processes, or cellular phenotypes, subject to confirmation of identity and purity.

Recommendations

• If used as a tool compound, confirm bioactivity with an orthogonal assay and include appropriate positive/negative controls.
• Establish cytotoxicity window (e.g., via viability assays) before phenotypic screening to avoid confounding effects.
• Record final solvent percentage and time-in-well to ensure reproducibility.

Buffer Applications

No buffer systems or formulation details are provided for SQ 28517.

General preparation guidance for assay buffers with small-molecule stocks

• Prepare a concentrated DMSO or ethanol stock and dilute into the target buffer (e.g., PBS, HBSS, HEPES-buffered saline, cell culture media) to a final organic content typically ≤0.1–1% v/v.
• To minimize precipitation: add stock slowly with vigorous mixing, pre-warm buffer (room temperature to 37°C as compatible), and consider using co-solvent ratios determined from small-scale solubility screening.
• For pH-sensitive compounds (if applicable), maintain buffer pH within ±0.2 units during dosing and incubation; avoid phosphate buffers if known to complex with the compound (information not available here—verify experimentally).

Item-specific buffer recommendations: Not specified for this item; refer to CoA/Spec Sheet.

Green Alternatives

Insufficient structural and application information is available to propose greener substitutes specific to SQ 28517.

General considerations for greener practice with small-molecule tools

• Prefer high-solubility media (aqueous buffers where feasible) to reduce reliance on high volumes of organic solvents.
• When organic stocks are necessary, DMSO or ethanol are commonly used at low final assay percentages; minimize solvent load by preparing higher-concentration stocks.
• For any synthesis or formulation steps (if applicable), apply solvent selection guides (e.g., ACS GCI, CHEM21) to favor water, EtOH, MeOH, 2-MeTHF, CPME, or EtOAc over chlorinated/aromatic solvents, consistent with compound stability.

Item-specific greener alternatives: Not specified for this item; refer to CoA/Spec Sheet.

Pharmaceutical Uses

This product is supplied strictly for research use only. No pharmaceutical, clinical, or therapeutic uses are provided or implied.

• Excipient status / compendial listings: Not specified for this item; refer to CoA/Spec Sheet.
• Formulation roles (general context): Small molecules may be explored as research actives in preclinical studies; any GMP-related considerations, impurity controls, and stability-indicating methods must be established independently.

Compliance reminder

• Not for human or veterinary use. Not for diagnostic procedures. For laboratory research use only, as noted in the product data.

Physical Properties

Item-specific physical constants are not provided in the product data for SQ 28517.

• Appearance: Not specified for this item; refer to CoA/Spec Sheet.
• Melting point: Not specified for this item; refer to CoA/Spec Sheet.
• Boiling point: Not specified for this item; refer to CoA/Spec Sheet.
• Density: Not specified for this item; refer to CoA/Spec Sheet.
• Refractive index: Not specified for this item; refer to CoA/Spec Sheet.
• pKa / logP / logD: Not specified for this item; refer to CoA/Spec Sheet.
• Solubility: Not specified for this item; refer to CoA/Spec Sheet.

General guidance (literature/practice)

• For small-molecule life-science tools, DMSO is often a suitable primary solvent for stock solutions; aqueous solubility depends on ionizable groups and salt form (if any).
• If the solid state is unknown, perform a small-scale solubility screen (e.g., DMSO, ethanol, methanol, water, PBS, and culture medium) with visual inspection and LC–MS confirmation of concentration.
• Document solution stability by periodic LC–UV or LC–MS to detect degradation or adsorption losses.

Quality & Grades

Grade/purity and stabilizer information are not provided in the product data for SQ 28517.

• Grade/Purity: Not specified for this item; refer to CoA/Spec Sheet.
• Stabilizers/inhibitors: Not specified for this item; refer to CoA/Spec Sheet.

Interpreting grades (general guidance)

• Research or biochemical grades typically emphasize identity and purity suitable for in vitro research; HPLC or LC–MS purity values (e.g., ≥95%) are commonly reported on the CoA.
• Trace metal or water specifications may be included for sensitive applications; in the absence of such specifications, assume general research use suitability and validate as needed.

Best practices

• Review the lot-specific CoA for assay method (HPLC/GC/LC–MS), purity, residual solvent profile, and water content (KF). Where critical, confirm with in-house methods.
• If low-UV work (chromatography, photochemistry) is planned, request UV cutoff and impurity profile; otherwise, treat as Not specified for this item; refer to CoA/Spec Sheet.

Reaction & Applications

The product is categorized for life-science research use, and no synthetic chemistry application data are provided. Without structure or functional group information, reaction usage cannot be recommended.

If employing SQ 28517 as a biochemical tool compound (general guidance)

• Prepare concentrated DMSO stocks and perform serial dilutions into the assay buffer immediately before use.
• Include vehicle controls matched to final DMSO percentage.
• Assess compound stability under assay conditions (temperature, pH, light) by LC–MS time-course.

If you intend to use it as a chemical building block

• Identity, reactivity, and protecting-group compatibility must be established from the CoA/structure. In the absence of such data, do not plan transformations.

For any reaction or application specifics: Not specified for this item; refer to CoA/Spec Sheet.

Reaction Conditions

No reaction condition guidance can be provided without structural and functional group information for SQ 28517.

• Solvents, bases/acids, catalysts, and temperature ranges: Not specified for this item; refer to CoA/Spec Sheet.
• Expected yields and times (literature): Not applicable without identity.

General advice

• If any transformations are attempted, conduct a small-scale feasibility screen under inert atmosphere as needed, monitor by LC–MS, and document all conditions for reproducibility.

Safety & Handling

Hazard classification and pictograms are not supplied in the product data for SQ 28517. Always consult the SDS for your specific lot before use.

• GHS classification: Not specified for this item; refer to SDS.
• Signal word and H-statements: Not specified for this item; refer to SDS.

General laboratory precautions

• Handle in a chemical fume hood; avoid inhalation, ingestion, and skin/eye contact.
• Recommended PPE: lab coat, safety glasses or face shield, and appropriate chemical-resistant gloves.
• Storage incompatibilities: Until functional groups are known, segregate from strong oxidizers, strong acids/bases, and reducing agents; keep container tightly closed.
• Special risks: If formulated as an organic powder/solid, avoid dust formation; if in DMSO, remember DMSO enhances dermal absorption—prevent skin exposure.

First-aid overview (defer to SDS)

• Skin/eye contact: Rinse with water for at least 15 minutes; remove contaminated clothing; seek medical advice.
• Inhalation: Move to fresh air; obtain medical attention if symptoms occur.
• Ingestion: Rinse mouth; do not induce vomiting; seek medical attention.

Storage per product data

• Store at −20°C. Shipped cold (ice chest + ice pads). Allow to equilibrate to room temperature in sealed container to minimize condensation before opening.

Solvent Selection

Solubility data for SQ 28517 are not specified in the product information. Selection should be guided by small-scale screening.

Recommended screening workflow (general)

• Start with DMSO (5–50 mg/mL targets) for primary stock, then evaluate aqueous compatibility by diluting into buffer (e.g., PBS, assay medium) to final DMSO ≤0.1–1% v/v.
• If DMSO is unsuitable, test: ethanol, methanol, acetonitrile, isopropanol, and mixtures with water. For hydrophobic materials, consider surfactants (0.01–0.1% Tween 80 or Pluronic F-127) as assay-permitted.
• For ionizable compounds (if known from CoA), adjust pH to favor solubility (acidic compounds dissolve better at basic pH; basic compounds at acidic pH), within biological assay constraints.

Practical notes

• Filter stocks through 0.22 µm PTFE (organics) or PVDF/nylon (aqueous-organic) to remove particulates.
• Verify actual concentration by UV (if chromophore known) or LC–MS/LC–UV to avoid dose misassignment due to partial solubility.
• Avoid repeated freeze–thaw of DMSO stocks; aliquot and store at −20°C per product data.

Storage & Reconstitution

Storage and shipping

• Storage condition (from product data): Store at −20°C.
• Shipping condition (from product data): Shipped in ice chest with ice pads to maintain cold chain.

Reconstitution (general guidance; item-specific solvent not provided)

• If supplied as a solid: Allow vial to reach room temperature in a desiccated environment before opening to prevent moisture uptake. Dissolve in an appropriate solvent identified via a small solubility screen (commonly DMSO for small-molecule tools). Record exact solvent and concentration.
• If supplied in solution: Mix gently after thaw; verify concentration by UV/LC–MS if critical to dosing.

Aliquoting and stability

• Prepare single-use aliquots to avoid repeated freeze–thaw. Store aliquots at −20°C in tightly sealed, chemically compatible vials.
• Protect from moisture and, if chromophore is suspected, from light (wrap vials in foil) until spectral behavior is known.
• Shelf-life/retention time: Not specified for this item; refer to CoA/Spec Sheet.

Research use note

• For research use only, as indicated. Consult the lot-specific CoA and SDS for any additional handling, stability, or hazard details.

Structure & Identity

SQ 28517 (SKU: S1455459) is listed under Life Science reagents; however, detailed structural identifiers are not provided in the product data.

• CAS: 92131-67-4
• Chemical name: Not specified for this item; refer to CoA/Spec Sheet.
• Molecular formula: Not specified for this item; refer to CoA/Spec Sheet.
• Molecular weight: Not specified for this item; refer to CoA/Spec Sheet.
• SMILES: Not specified for this item; refer to CoA/Spec Sheet.
• InChIKey: Not specified for this item; refer to CoA/Spec Sheet.

Structural features

• Functional groups, ring systems, stereochemistry, and ionization state: Not specified for this item; refer to CoA/Spec Sheet.

Notes for identity confirmation (general best practices)

• Verify identity via orthogonal methods (e.g., 1H/13C NMR, LC–MS, HRMS) if structural details are required for your workflow.
• Match CAS, catalog number, and lot number on the Certificate of Analysis (CoA) to your vial before use.

Synthetic Utility

Structural information is not available for SQ 28517; therefore, synthetic roles, functional-group transformations, or retrosynthetic considerations cannot be defined.

• Key functional groups and reactivity: Not specified for this item; refer to CoA/Spec Sheet.
• Named reactions or coupling strategies: Not specified for this item; refer to CoA/Spec Sheet.

If planning synthetic use (general guidance)

• Obtain full structure (SMILES/InChI) and confirm with NMR/HRMS.
• Assess protecting-group compatibility, redox stability, and heteroatom basicity/acidity before route design.
• Establish analytical methods (HPLC, LC–MS) and reference standards for in-process control.

Target Specificity

Target, selectivity, and off-target profile are not provided in the product data.

• Primary target/epitope: Not specified for this item; refer to CoA/Spec Sheet.
• Secondary/off-targets: Not specified for this item; refer to CoA/Spec Sheet.
• Species reactivity (if biological target): Not specified for this item; refer to CoA/Spec Sheet.

Recommendation

• Establish potency and selectivity experimentally using appropriate panels or orthogonal assays before drawing mechanistic conclusions.