Sucralose - ≥98% , CAS No.56038-13-2

CAS: 56038-13-2 Cat. No.: S107614 Molecular Weight: 397.63 Beilstein Registry Number: 3654410 EC Number: 259-952-2 PubChem CID: 71485

GRADE & PURITY ≥98%

Synonyms

E955 | 4,1',6'-Trichloro-4,1',6'-trideoxy-galacto-sucrose | Biocoline | CCG-213995 | Sucrazit | CCRIS 8449 | Citric acid, trisodium salt | INS-955 | SUCRALOSE [II] | AKOS015962432 | alpha-D-Galactopyranoside, 1,6-dichloro-1,6-dideoxy-beta-D-fructofuranosy

Storage

Room temperature

Shipped In

Normal

Overview

Sucralose is a non-caloric sugar used as a sweetener that activates T1R2/T1R3 sweet taste receptors and modulates Glukagon-like peptide-1, glucose-dependent insulinotrophic peptide, and incretin secretion.

Specifications

Synonyms

E955 | 4, 1', 6'-Trichloro-4, 1', 6'-trideoxy-galacto-sucrose | Biocoline | CCG-213995 | Sucrazit | CCRIS 8449 | Citric acid, trisodium salt | INS-955 | SUCRALOSE [II] | AKOS015962432 | alpha-D-Galactopyranoside, 1, 6-dichloro-1, 6-dideoxy-beta-D-fructofuranosy

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

A synthetic sweetener that can be detected by humans. It can activate the T1R2/T1R3 sweet taste receptors on intestinal endocrine cells, causing an increase in hormone secretion of glucagon like peptide-1 and glucose dependent insulin peptides.

Storage

Room temperature

Shipped In

Normal

Purity

≥98%

Names and Identifiers

• Pubchem Sid: 488184657
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488184657
• Canonical Smiles: C(C1C(C(C(C(O1)OC2(C(C(C(O2)CCl)O)O)CCl)O)O)Cl)O
• IUPAC Name: (2R,3R,4R,5R,6R)-2-[(2R,3S,4S,5S)-2,5-bis(chloromethyl)-3,4-dihydroxyoxolan-2-yl]oxy-5-chloro-6-(hydroxymethyl)oxane-3,4-diol
• InChIKey: BAQAVOSOZGMPRM-QBMZZYIRSA-N
• INCHI: 1S/C12H19Cl3O8/c13-1-4-7(17)10(20)12(3-14,22-4)23-11-9(19)8(18)6(15)5(2-16)21-11/h4-11,16-20H,1-3H2/t4-,5-,6+,7-,8+,9-,10+,11-,12+/m1/s1
• Isomeric SMILES: C([C@@H]1[C@@H]([C@@H]([C@H]([C@H](O1)O[C@]2([C@H]([C@@H]([C@H](O2)CCl)O)O)CCl)O)O)Cl)O
• WGK Germany: 3
• RTECS: LW5440140
• PubChem CID: 71485
• Molecular Weight: 397.63
• Beilstein: 3654410
• Reaxy-Rn: 3654410

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic oxygen compounds
    • Class Organooxygen compounds
      • Subclass Carbohydrates and carbohydrate conjugates
        • Level5 Glycosyl compounds
          • Level6 C-glycosyl compounds

• Kingdom: Organic compounds
• Superclass: Organic oxygen compounds
• Class: Organooxygen compounds
• Subclass: Carbohydrates and carbohydrate conjugates
• Intermediate Tree Nodes: Glycosyl compounds
• Direct Parent: C-glycosyl compounds
• Alternative Parents: Ketals Oxanes Monosaccharides Tetrahydrofurans Secondary alcohols Chlorohydrins Oxacyclic compounds Primary alcohols Organochlorides Hydrocarbon derivatives Alkyl chlorides
• Molecular Framework: Aliphatic heteromonocyclic compounds
• Substituents: C-glycosyl compound - Ketal - Oxane - Monosaccharide - Tetrahydrofuran - Secondary alcohol - Chlorohydrin - Halohydrin - Acetal - Oxacycle - Organoheterocyclic compound - Hydrocarbon derivative - Organohalogen compound - Organochloride - Primary alcohol - Alkyl halide - Alkyl chloride - Alcohol - Aliphatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as c-glycosyl compounds. These are glycoside in which a sugar group is bonded through one carbon to another group via a C-glycosidic bond.
• External Descriptors: organochlorine compound - disaccharide derivative

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

CA2 Tclin Carbonic anhydrase 2 (1 Activities)

Discover Target: CA2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CA2 Tclin Carbonic anhydrase II (17698 Activities)

Discover Target: CA2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CA9 Tclin Carbonic anhydrase IX (8255 Activities)

Discover Target: CA9

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Homo sapiens (32628 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TAS2R31 Tchem Taste receptor type 2 member 31 (86 Activities)

Discover Target: TAS2R31

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TAS2R10 Tchem Taste receptor type 2 member 10 (51 Activities)

Discover Target: TAS2R10

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HEK-293T (167025 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TAS2R46 Tchem Taste receptor type 2 member 46 (155 Activities)

Discover Target: TAS2R46

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: Soluble in Water.
• Specific Rotation[α]: 86.0° (C=1,H2O)
• Melt Point(°C): 130°C
• Molecular Weight: 397.600 g/mol
• XLogP3: -1.500
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 5
• Exact Mass: 396.015 Da
• Monoisotopic Mass: 396.015 Da
• Topological Polar Surface Area: 129.000 Ų
• Heavy Atom Count: 23
• Formal Charge: 0
• Complexity: 405.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 9
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Lingling Tian, Jingyan Shi, Wei Li, Yuan Zhang, Xinghua Gao.  (2023)  Hollow Microfiber Assembly-Based Endocrine Pancreas-on-a-Chip for Sugar Substitute Evaluation.  Advanced Healthcare Materials,      [PMID:37751946] [10.1002/adhm.202302104]

2. He Yue, Chen Jianshe, Shi Weiyao, Shi Jingang, Ma Tian, Wang Xinmiao.  (2023)  Can nonvolatile tastants be smelled during food oral processing?.  CHEMICAL SENSES,      [PMID:37590987] [10.1093/chemse/bjad028]

3. Zhang Yuntao, Liu Lin, Wei Chunbo, Wang Xuanyang, Li Ran, Xu Xiaoqing, Zhang Yingfeng, Geng Guannan, Dang Keke, Ming Zhu, Tao Xinmiao, Xu Huan, Yan Xuemin, Zhang Jia, Hu Jinxia, Li Ying.  (2023)  Vitamin K2 supplementation improves impaired glycemic homeostasis and insulin sensitivity for type 2 diabetes through gut microbiome and fecal metabolites.  BMC Medicine,  21  (1): (1-16).  [PMID:37147641] [10.1186/s12916-023-02880-0]

4. Xue Mei, Wenchang Wang, Qingyi Li, Minxian Wu, Liyin Bu, Zhidong Chen.  (2023)  A novel electrochemical sensor based on gold nanobipyramids and poly-L-cysteine for the sensitive determination of trilobatin.  ANALYST,  148  (10): (2335-2342).  [PMID:37186001] [10.1039/D3AN00368J]

5. Xuejiao Zhang, Jiaxin Gu, Congying Zhao, Yaozhong Hu, Bowei Zhang, Jin Wang, Huan Lv, Xuemeng Ji, Shuo Wang.  (2021)  Sweeteners Maintain Epithelial Barrier Function Through the miR-15b/RECK/MMP-9 Axis, Remodel Microbial Homeostasis, and Attenuate Dextran Sodium Sulfate-Induced Colitis in Mice.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:34962394] [10.1021/acs.jafc.1c06788]

6. Xiaofeng Wei, Ying Chen, Shan He, Huiting Lian, Xuegong Cao, Bin Liu.  (2021)  L-histidine-regulated zeolitic imidazolate framework modified electrochemical interface for enantioselective determination of L-glutamate.  ELECTROCHIMICA ACTA,      [PMID:] [10.1016/j.electacta.2021.139464]

7. Ferry Saputra, Yu-Heng Lai, Rey Arturo T. Fernandez, Allan Patrick G. Macabeo, Hong-Thih Lai, Jong-Chin Huang, Chung-Der Hsiao.  (2021)  Acute and Sub-Chronic Exposure to Artificial Sweeteners at the Highest Environmentally Relevant Concentration Induce Less Cardiovascular Physiology Alterations in Zebrafish Larvae.  Biology-Basel,  10  (6): (548).  [PMID:34207293] [10.3390/biology10060548]

8. Pingping Cui, Qiuxiang Yin, Shihao Zhang, Xiaowei Cheng, Jiayu Dai, Zaixiang Zhang, Ling Zhou, Chuang Xie.  (2019)  The effect of solvents on crystal morphology of sucralose: Experiments and molecular dynamics simulation studies.  JOURNAL OF CRYSTAL GROWTH,      [PMID:] [10.1016/j.jcrysgro.2019.125398]

9. Yong Li, Tingting Yang, Qing Yao, Songsong Li, En Fang, Yankun Li, Chao Liu, Weimin Li.  (2019)  Metformin prevents colonic barrier dysfunction by inhibiting mast cell activation in maternal separation-induced IBS-like rats.  NEUROGASTROENTEROLOGY AND MOTILITY,  31  (5): (e13556).  [PMID:30740845] [10.1111/nmo.13556]

10. Yin Xu, Ying Wu, Wei Zhang, Xiaohui Fan, Yan Wang, Hui Zhang.  (2018)  Performance of artificial sweetener sucralose mineralization via UV/O3 process: Kinetics, toxicity and intermediates.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2018.07.090]

11. Hongmei Zhang, Shixin Sun, Yanqing Wang, Zhenghao Fei, Jian Cao.  (2018)  Binding mechanism of five typical sweeteners with bovine serum albumin.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:30015031] [10.1016/j.saa.2018.07.013]

12. Hongmei Zhang, Shixin Sun, Yanqing Wang, Jian Cao.  (2017)  Interaction of sucralose with whey protein: Experimental and molecular modeling studies.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:28666158] [10.1016/j.saa.2017.06.030]

13. Jiang Ting-Fu, Chong Lei, Yue Mei-E, Wang Yuan-Hong, Lv Zhi-Hua.  (2015)  Separation and Determination of Carbohydrates in Food Samples by Capillary Electrophoresis Using Dynamically Coating the Capillary with Indirect UV Detection.  Food Analytical Methods,  8  (10): (2588-2594).  [PMID:] [10.1007/s12161-015-0157-z]

14. Longmei Yao, Xue Mei, Jiajia Zhi, Wenchang Wang, Qingyi Li, Ding Jiang, Xiaohui Chen, Zhidong Chen.  (2024)  A novel electrochemiluminescent sensor based on AgMOF@N-CD composites for sensitive detection of trilobatin.  ANALYST,      [PMID:39264159] [10.1039/D4AN01102C]

15. Dali Zhuo, Xiaoyu Dong, Linghuan Li, Ronghua Zeng, Chao Tan, Hong Luo, Zhirong Zou.  (2025)  Detection of Ca2+ in water samples and calcium gluconate oral liquids using gas pressure meter as portable detector.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2025.113116]

16. Jingyan Shi, Jianing Li, Wentao Su, Chang Xue, Yuan Zhang, Xinghua Gao.  (2024)  Engineered microenvironments and pancreatic islet-on-chips for screening sugar substitute and antidiabetic compounds.  FOOD RESEARCH INTERNATIONAL,      [PMID:39614569] [10.1016/j.foodres.2024.115084]

17. Li Hao, Du Yu, Cheng Kaiwen, Chen Yuxi, Wei Ling, Pei Yujun, Wang Xiaoyu, Wang Lan, Zhang Ye, Hu Xiaoxin, Lu Yi, Zhu Xiangjia.  (2024)  Gut microbiota-derived indole-3-acetic acid suppresses high myopia progression by promoting type I collagen synthesis.  Cell Discovery,  10  (1): (1-14).  [PMID:39187483] [10.1038/s41421-024-00709-5]

18. Li Zhang, Lei Feng, Lin Yang, Hao Wan.  (2025)  Noninvasive Detection and Monitoring of the Integrity of the Intestinal Barrier through NIR-II Fluorescence Imaging and Colorimetric Urinalysis.  ACS Applied Materials & Interfaces,      [PMID:39977645] [10.1021/acsami.4c20263]

19. Zizhang Wang, Hao Li, Yuxiang Weng.  (2024)  OsFKBP12 transduces the sucrose signal from OsNIN8 to the OsTOR pathway in a loosely binding manner for cell division.  iScience,      [PMID:39811636] [10.1016/j.isci.2024.111555]

20. Yue He, Jianshe Chen, Weiyao Shi, Jingang Shi.  (2024)  Retronasal sensation of nonvolatile sweeteners and its impacts on the flavor perception of beverages.  FOOD QUALITY AND PREFERENCE,      [PMID:] [10.1016/j.foodqual.2024.105107]

21. Jing Xiao, Dali Zhuo, Jiayuan Tang, Jihong Chen, Chao Tan, Shu Zhang, Shichao Li, Zhirong Zou.  (2024)  Selective and sensitive detection of cyclamate in beverages using a portable pressure meter: A specific reaction-based analytical kit.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2024.110959]

22. Luyao Yang, Shuangshuang Wang, Jing Jin, Jiahui Wang, Wenyue Chen, Yun Xue, Liang Sheng, Yongning Zhai, Weifeng Yao.  (2024)  Sucralose triggers insulin resistance leading to follicular dysplasia in mice.  REPRODUCTIVE TOXICOLOGY,      [PMID:38880404] [10.1016/j.reprotox.2024.108644]

23. Wenjiao Liu, Han wang, Qi Mu, Ting Gong.  (2024)  Taste receptor T1R3 regulates testosterone synthesis via the cAMP-PKA-SP1 pathway in testicular Leydig cells.  THERIOGENOLOGY,      [PMID:39476553] [10.1016/j.theriogenology.2024.10.019]

24. Jun Hu, Ji Feng, Yan Bai, Zhi-Sheng Yao, Xiao-Yu Wu, Xin-Yu Hong, Guo-Dong Lu, Kun Xue.  (2025)  Sucralose Promotes Benzo(a)Pyrene-Induced Renal Toxicity in Mice by Regulating P-glycoprotein.  Antioxidants,  14  (4): (474).  [PMID:40298799] [10.3390/antiox14040474]

25. Wen Zhang, Shiyuan Ni, Zike Huang, Zhequan Wang, Zhiwei Liu.  (2025)  Spatiotemporal Variations and Future Trends of Sucralose Contamination in Major Rivers of Zhejiang, China: An Emerging Concern and Sustainability Challenge.  Sustainability,  17  (22): (9935).  [PMID:] [10.3390/su17229935]

26. Lele Chen, Guanchi Liu, Wei Su, Xiaoxue Hu, Jianshe Chen, Yue He, Xinmiao Wang.  (2025)  Retro-nasal perception of sucralose aerosols in model wine systems.  FOOD RESEARCH INTERNATIONAL,      [PMID:41652693] [10.1016/j.foodres.2025.118282]

27. Yuqing Liang, Yan Liu, Xuelong Cao, Qi Yan, Qiuning Hu, Jiahe Zhuang, Defu He.  (2026)  Sucralose and PMMA Microplastics Synergistically Induce Obesity with Altered Locomotion and Metabolism in Caenorhabditis elegans.  ENVIRONMENTAL SCIENCE & TECHNOLOGY,      [PMID:41739734] [10.1021/acs.est.5c12134]