T988C , CAS No.823802-57-9

CAS: 823802-57-9 Cat. No.: T1452552 Formula: C₂₃H₂₀N₄O₄S₂ Molecular Weight: 480.56

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

T988C is a heptacyclic epidithiodioxopiperazine (ETP) natural product. T988C shows strong cytotoxicity to cultured P388 leukemia cells.

Specifications

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Molecular Weight: 480.56

Application Protocols

Item-specific tested applications and recommended dilutions were not provided.

• Validated techniques (WB, IHC, IF, FC, ELISA, etc.): Not specified for this item; refer to CoA/Spec Sheet.
• Recommended working concentrations/dilutions: Not specified for this item; refer to CoA/Spec Sheet.
• Positive/negative controls: Not specified for this item; refer to CoA/Spec Sheet.

General guidance (not item-specific)

• Begin with small pilot titrations to identify optimal concentrations. Include appropriate controls (vehicle, isotype, or unrelated protein/peptide controls, as applicable).
• Record lot number, stock concentration, solvent, and storage conditions for reproducibility.

Biological Roles

Item-specific biological role/target: Not specified for this item; refer to CoA/Spec Sheet.

General considerations (not item-specific)

• For life-science reagents, biological role depends on class: antibodies (bind specific antigens), peptides (can be antigens, enzyme substrates/inhibitors), proteins/enzymes (catalysis or signaling), or small molecules (pathway modulators). Experimental design should align concentration, exposure time, and matrix (cell-free vs cell-based) with the reagent’s expected mechanism.
• Incorporate appropriate controls: isotype controls for antibodies, scrambled/negative control peptides, or inactive analogs/vehicle controls for small molecules.
• Confirm species cross-reactivity and epitope mapping (for antibodies) or sequence and purity (for peptides/proteins) prior to critical experiments.

Buffer Applications

Item-specific buffer system recommendations: Not specified for this item; refer to CoA/Spec Sheet.

General guidance (not item-specific)

• If the reagent requires reconstitution: commonly used buffers include PBS (pH ~7.2–7.4), HEPES (pH 7.0–8.0), and Tris (pH 7.0–9.0). Choose ionic strength and pH to maintain solubility and functional stability.
• For proteins/antibodies: consider additives (e.g., 0.1% BSA, 10–50% glycerol, 0.02–0.05% sodium azide) where compatible with downstream assays. Avoid azide with HRP-based detection or live cells.
• For peptides: low ionic strength water or dilute acid (e.g., 0.1% TFA or acetic acid) may assist dissolution before buffer dilution (literature guidance, not item-specific).

Green Alternatives

This section is not typically applicable without knowing the reagent’s identity and use phase.

General guidance (not item-specific)

• If the material is a small molecule tool compound dissolved in organic solvent, consider greener solvent choices for stock preparation and cleaning (e.g., water/ethanol where compatible; avoid chlorinated solvents). For reaction-phase chemistry (if applicable), evaluate 2-MeTHF or CPME as greener ethers vs THF, and EtOAc vs DCM (literature guidance).
• If the material is a biomolecule in aqueous buffer, minimize use of hazardous organics; employ aqueous cleaning protocols and appropriate waste segregation.
• Implement microscale experiments to reduce waste. Use closed containers and cold-chain logistics efficiently to reduce dry ice/ice pack usage while maintaining product integrity.

Pharmaceutical Uses

No pharmaceutical or clinical uses are claimed or supported for this catalog item. For research use only.

General formulation context (not item-specific)

• If the reagent is ultimately used in pre-formulation studies (research stage), characterize stability vs pH, ionic strength, temperature, and excipients (e.g., sugars, polyols, amino acids) as appropriate for the class of molecule. Document excipient compatibility and storage stability.
• Observe all institutional and regulatory restrictions; this product is not intended for human or veterinary use.

Physical Properties

Item-specific physical data

• Appearance: Not specified for this item; refer to CoA/Spec Sheet.
• Melting point: Not specified for this item; refer to CoA/Spec Sheet.
• Boiling point: Not specified for this item; refer to CoA/Spec Sheet.
• Density: Not specified for this item; refer to CoA/Spec Sheet.
• Solubility: Not specified for this item; refer to CoA/Spec Sheet.
• LogP/logD: Not specified for this item; refer to CoA/Spec Sheet.
• pKa: Not specified for this item; refer to CoA/Spec Sheet.
• Refractive index/UV cutoff: Not specified for this item; refer to CoA/Spec Sheet.

General guidance (literature/typical, not item-specific)

• For life-science reagents, physical form may be lyophilized solid, solution concentrate, or powder. Solubility and stability depend strongly on identity (e.g., peptides often dissolve in water, dilute acid, or buffers; hydrophobic small molecules may require DMSO or co-solvents).
• If the reagent is proteinaceous/antibody, it is typically formulated in buffered saline with stabilizers and is not amenable to classical “solvent” property descriptors.
• Always confirm lot-specific solubility recommendations and concentration limits from the CoA/Spec Sheet before preparing stocks. Perform small-scale solubility scouting (e.g., water, buffer, DMSO) if permitted and identity suggests ambiguity.

Quality & Grades

Item-specific quality information

• Grade/Purity: Not specified for this item; refer to CoA/Spec Sheet.
• Research Use Only: For research use only (not for diagnostic, clinical, or therapeutic use).

Guidance on grades (general, not item-specific)

• Analytical/biochemical grade indicates tight control of contaminants that interfere with assays (e.g., nucleases, proteases, endotoxin). HPLC grade (for solvents) emphasizes low nonvolatile residue and low UV absorbance; not applicable unless this product is a solvent.
• For proteins/antibodies: quality may be reported by purity (SDS-PAGE/HPLC), binding/functional titer, endotoxin level, host/species, and preservative content. For peptides/small molecules: purity is typically by HPLC/LC-MS with identity confirmation (MS, NMR).
• Stabilizers/preservatives (e.g., BSA, trehalose, glycerol, azide) impact downstream compatibility (e.g., enzymatic assays, cell culture). Confirm presence/absence on lot documentation.

Recommendations

• Request the lot-specific CoA for exact purity, residual solvent, water content, endotoxin/bioburden, and any stabilizers. Align grade with application requirements (e.g., low endotoxin for cell culture, carrier-free for conjugations).

Reaction & Applications

Item-specific applications: Not specified for this item; refer to CoA/Spec Sheet and the Manufacturer Applications section.

Contextual guidance (not item-specific)

• The catalog path indicates Life Science use. Such reagents are typically applied in biochemical assays, cell-based studies, molecular biology workflows, or immunoassays rather than in classical synthetic reactions.
• Before use, identify the reagent class (small molecule modulator, peptide/protein, antibody, nucleic acid, etc.) to select appropriate assay formats, controls, and handling (e.g., avoiding proteases for protein reagents, minimizing DMSO in cellular assays for small molecules).
• Validate concentration ranges experimentally by titration; include vehicle controls (e.g., DMSO only) where applicable. Document lot number and preparation details for reproducibility.

Reaction Conditions

Item-specific reaction conditions: Not specified for this item; refer to CoA/Spec Sheet.

General guidance (not item-specific)

• For biological applications, “conditions” usually refer to assay buffers, temperature (4°C for binding incubations; 20–37°C for enzyme/cell assays), and incubation times. Optimize empirically with proper controls.
• If chemical modification/conjugation is planned (e.g., biotinylation, dye labeling), select chemistries matched to known functional handles (NHS–amine, maleimide–thiol) and control pH/solvent accordingly (e.g., pH 7.0–7.5 for NHS-ester reactions; pH 6.5–7.0 for maleimide–thiol). These are general literature guidelines and not specific to this item.

Safety & Handling

Item-specific safety data

• GHS classification: Not specified for this item; refer to SDS.
• Signal word / Pictograms / H-statements: Not specified for this item; refer to SDS.

General laboratory safety (not item-specific; defer to SDS)

• Handle in a well-ventilated area or chemical fume hood. Avoid inhalation of dust/aerosols and contact with skin/eyes. Use appropriate PPE: lab coat, safety glasses, and disposable nitrile gloves; upgrade PPE based on SDS.
• For potential bioactive life-science reagents, minimize aerosol generation; consider biosafety cabinet handling if the material is proteinaceous or if procedures generate aerosols.
• Incompatibilities are identity-dependent. In general, segregate from strong oxidizers/reductants and acids/bases until compatibility is known. Avoid metal contact if the reagent is thiol-containing or chelating (general precaution).
• First aid (overview): If inhaled—move to fresh air; skin/eye contact—rinse with copious water; ingestion—rinse mouth. Seek medical attention; provide SDS to responders.
• Spill response: Contain with absorbent, avoid dust. For solutions, wipe with suitable detergent and water. Dispose as hazardous chemical waste in accordance with institutional and local regulations.
• SDS is the authoritative source for hazards, exposure limits, and specific cleanup and disposal instructions.

Solvent Selection

Item-specific solvent recommendations: Not specified for this item; refer to CoA/Spec Sheet.

General decision framework (not item-specific)

• If small molecule and hydrophobic: prepare concentrated stocks in DMSO (e.g., 10–50 mM) then dilute into aqueous buffers, keeping final DMSO ≤0.1–0.5% v/v for most biological assays.
• If polar small molecule or salt: start with water or buffer (PBS, HEPES). Adjust pH to enhance ionization/solubility as appropriate.
• If peptide/protein: reconstitute in sterile water, PBS, or recommended buffer; brief sonication may help. For difficult peptides, use minimal DMSO or 10–50% acetonitrile/water with 0.1% TFA, then dilute into buffer.
• If antibody: follow supplier buffer; many come ready-to-use in PBS with stabilizers. Avoid strong organic solvents.

Comparison (literature, typical)

• DMSO: excellent for hydrophobes; miscible with water; may affect cells/enzymes at >0.5%.
• Water/PBS: biologically compatible; limited for hydrophobes.
• MeOH/EtOH: intermediate polarity; may denature proteins; use cautiously.

Always confirm compatibility with downstream assays and filter sterilize (0.22 µm) where sterility is required.

Storage & Reconstitution

Item-specific instructions

• Storage: Store at −20°C (per Product Data). Maintain cold chain during shipment (supplied on ice packs). Avoid frost-free freezers that cycle above 0°C.
• Reconstitution: Not specified for this item; refer to CoA/Spec Sheet.

General best practices (not item-specific)

• Upon receipt: Inspect packaging temperature. Allow container to equilibrate to room temperature in a desiccator before opening to prevent condensation.
• If lyophilized: Reconstitute with sterile water or appropriate buffer based on identity. For hydrophobic small molecules, first dissolve in DMSO to make a concentrated stock, then dilute into buffer immediately before use. For proteins/antibodies, reconstitute in PBS or recommended buffer; gentle mixing avoids foaming/denaturation.
• Aliquoting: Prepare single-use aliquots to minimize freeze–thaw. Label with concentration, solvent, date, and lot.
• Storage after reconstitution: Unless otherwise specified, store short-term at 2–8°C (days) and long-term at −20 to −80°C. Avoid repeated freeze–thaw; consider adding stabilizers appropriate to the reagent class (e.g., 10–50% glycerol for proteins; verify compatibility first).
• Light/air sensitivity: If the reagent is dye-conjugated or oxidation-sensitive, protect from light and purge headspace with inert gas where appropriate.
• Always defer to the lot-specific CoA/Spec Sheet for definitive storage limits, compatible buffers/solvents, and stability timelines.

Structure & Identity

• SKU: T1452552
• Product Name: T988C
• CAS: 823802-57-9
• Category: Life Science (per catalog path)
• Molecular formula: Not specified for this item; refer to CoA/Spec Sheet.
• Molecular weight: Not specified for this item; refer to CoA/Spec Sheet.
• SMILES: Not specified for this item; refer to CoA/Spec Sheet.
• InChIKey: Not specified for this item; refer to CoA/Spec Sheet.

Item-specific facts (from Product Data)

• Structural identifiers (formula, MW, SMILES, InChIKey) were not provided in the listing.
• Storage: Store at −20°C. Shipped in ice chest with ice pads.

General notes

• “T988C” appears to be a supplier/laboratory code or trade name and does not inherently define chemical structure or biological target. Without structural identifiers, the compound class (small molecule, peptide, protein, antibody, etc.) cannot be confirmed from the Product Data alone.
• If structure or sequence is required for method development, request the lot-specific Certificate of Analysis (CoA) or technical data sheet to obtain definitive identifiers (e.g., sequence for peptides/proteins, or SMILES/InChI for small molecules).

2D structural description

• Not specified for this item; refer to CoA/Spec Sheet. Once provided, a 2D description can highlight functional groups (e.g., amide, aromatic, heterocycles), ring systems, and any stereochemical centers if applicable.

Synthetic Utility

This section is typically not applicable for life-science reagents whose primary use is biological assay or detection.

If the item is a small molecule (general, not item-specific)

• Synthetic utility would depend on functional groups present (e.g., halides for cross-coupling, amines/carboxylic acids for amide coupling, azides/alkynes for click chemistry). Without structure, no claims can be made for this item.

Recommendation

• Consult the CoA/Spec Sheet for functional group information if derivatization or conjugation chemistry is intended.

Target Specificity

Item-specific target/epitope/clone/isotype information was not provided for this product.

• Target antigen/name: Not specified for this item; refer to CoA/Spec Sheet.
• Species reactivity: Not specified for this item; refer to CoA/Spec Sheet.
• Clone/isotype (if antibody): Not specified for this item; refer to CoA/Spec Sheet.

Note: If T988C is an antibody or binding protein, consult the technical data sheet for validated targets, cross-reactivity, and application-specific performance data.