TAPS - ≥99.5%(T) , CAS No.29915-38-6

CAS: 29915-38-6 Cat. No.: T108962 Molecular Weight: 243.28 Beilstein Registry Number: 2452420 EC Number: 249-954-1 PubChem CID: 121591

GRADE & PURITY ≥99.5%(T)

Synonyms

TAPS | 3-[[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino]propane-1-sulfonic acid | 3-((1,3-Dihydroxy-2-(hydroxymethyl)propan-2-yl)amino)propane-1-sulfonic acid | N-Tris(hydroxymethyl)methyl-3-aminopropanesulfonic Acid | N-Tris(hydroxymethyl)methyl-3-am

Storage

Room temperature

Shipped In

Normal

Overview

TAPS is a zwitterionic buffer used in biochemistry and molecular biology. It has a useful pH range of 7.7 - 9.1. TAPS has been utilized in capillary electrophoresis of DNA and DNA-dye complexes. Dyes can be separated by planar chromatography with electroosmotic flow containing 1 mM TAPS in the mobile phase. The stability constants of metal ions with TAPS have been investigated through the use of capillary electrophoresis. TAPS has also been shown to inhibit the activity of connexin channels. The activity of various carbonic anhydrases has been studied using TAPS physiological buffer, pKa = 8.4 at 20° C.

Specifications

Synonyms

TAPS | 3-[[1, 3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino]propane-1-sulfonic acid | 3-((1, 3-Dihydroxy-2-(hydroxymethyl)propan-2-yl)amino)propane-1-sulfonic acid | N-Tris(hydroxymethyl)methyl-3-aminopropanesulfonic Acid | N-Tris(hydroxymethyl)methyl-3-am

Specifications & Purity

≥99.5%(T)

Storage

Room temperature

Shipped In

Normal

Purity

≥99.5%(T)

Names and Identifiers

• Pubchem Sid: 488187651
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488187651
• Canonical Smiles: C(CNC(CO)(CO)CO)CS(=O)(=O)O
• IUPAC Name: 3-[[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino]propane-1-sulfonic acid
• InChIKey: YNLCVAQJIKOXER-UHFFFAOYSA-N
• INCHI: 1S/C7H17NO6S/c9-4-7(5-10,6-11)8-2-1-3-15(12,13)14/h8-11H,1-6H2,(H,12,13,14)
• Isomeric SMILES: C(CNC(CO)(CO)CO)CS(=O)(=O)O
• WGK Germany: 3
• PubChem CID: 121591
• Molecular Weight: 243.28
• Beilstein: 2452420
• Reaxy-Rn: 2452420

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Organic sulfonic acids and derivatives
      • Subclass Organosulfonic acids and derivatives

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Organic sulfonic acids and derivatives
• Subclass: Organosulfonic acids and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Organosulfonic acids
• Alternative Parents: Sulfonyls Alkanesulfonic acids 1,2-aminoalcohols Dialkylamines Primary alcohols Organopnictogen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Organosulfonic acid - Sulfonyl - Alkanesulfonic acid - 1,2-aminoalcohol - Secondary aliphatic amine - Secondary amine - Organopnictogen compound - Organic oxygen compound - Alcohol - Primary alcohol - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Organic nitrogen compound - Amine - Organic oxide - Hydrocarbon derivative - Aliphatic acyclic compound
• Description: This compound belongs to the class of organic compounds known as organosulfonic acids. These are compounds containing the sulfonic acid group, which has the general structure RS(=O)2OH (R is not a hydrogen atom).
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: water: 0.5 g/mL, clear, colorless
• Flash Point(°F): >230 ℉
• Flash Point(°C): >110°C
• Melt Point(°C): 230-235°C
• Molecular Weight: 243.280 g/mol
• XLogP3: -5.400
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 8
• Exact Mass: 243.078 Da
• Monoisotopic Mass: 243.078 Da
• Topological Polar Surface Area: 135.000 Ų
• Heavy Atom Count: 15
• Formal Charge: 0
• Complexity: 247.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Yuting Li, Luhan Wang, Minhua Qian, Shengda Qi, Lei Zhou, Qiaosheng Pu.  (2022)  Concise analysis of γ-hydroxybutyric acid in beverages and urine by capillary electrophoresis with capacitively coupled contactless conductivity detection using 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid as background electrolyte.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:35675730] [10.1016/j.chroma.2022.463191]

2. Liye Yang, Guangchao Pan, Piwang Zhang, Qiang Liu, Xing Liu, Yan Li, Ying Liang, Min Zhang.  (2021)  3D printed two-in-one on-capillary detector: Combining contactless conductometric and photometric detection for capillary electrophoresis.  ANALYTICA CHIMICA ACTA,      [PMID:33867034] [10.1016/j.aca.2021.338427]

3. Wang Chen, Wang Qian, Li Shuangsi, Zhang Man, Zhao Weifeng, Sun Shudong, Zhao Changsheng.  (2017)  One-pot synthesis of highly hemocompatible polyurethane/polyethersulfone composite membranes.  POLYMER BULLETIN,  74  (9): (3797-3818).  [PMID:] [10.1007/s00289-017-1922-5]

4. Rui Zhao, Xiangjian Liu, Marlene Davis Ekpo, Yongju He, Songwen Tan.  (2024)  Exploring the Cryopreservation Mechanism and Direct Removal Strategy of TAPS in Red Blood Cell Cryopreservation.  ACS Biomaterials Science & Engineering,      [PMID:38832439] [10.1021/acsbiomaterials.3c01701]