tetracycline - ≥98% , CAS No.60-54-8

CAS: 60-54-8 Cat. No.: T136961 Formula: C₂₂H₂₄N₂O₈ Molecular Weight: 444.44 EC Number: 200-481-9 PubChem CID: 54675776

GRADE & PURITY ≥98%

Synonyms

Liquamycin | Vetacyclinum | Tetrazyklin | Hostacyclin | Omegamycin | Tetradecin | Cyclopar | Panmycin | Tsiklomitsin | Tetracyclinum | Sumycin | Ambramycin | Tetracyn | Tetraverine | Achromycin V | Deschlorobiomycin | Achromycin | Tsiklomistsin | Tetracyc

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Overview

产品介绍：

Tetracycline 是一种具有口服活性的广谱抗生素。Tetracycline 对多种细菌，包括革兰氏阳性菌、革兰氏阴性菌、衣原体、支原体和立克次体具有活性。Tetracycline 可用于感染的研究

Specifications

Synonyms

Liquamycin | Vetacyclinum | Tetrazyklin | Hostacyclin | Omegamycin | Tetradecin | Cyclopar | Panmycin | Tsiklomitsin | Tetracyclinum | Sumycin | Ambramycin | Tetracyn | Tetraverine | Achromycin V | Deschlorobiomycin | Achromycin | Tsiklomistsin | Tetracyc

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

Tetracycline inhibits bacterial protein synthesis elongation at the level of aminoacyl-tRNA binding to the 30S ribosome. Tetracycline passively diffuses through porin channels in the bacterial cell membrane. It also binds to the bacterial 50S ribosomal su

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Names and Identifiers

Pubchem Sid

488201682

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/488201682

Canonical Smiles

CC1(C2CC3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O

IUPAC Name

(4S,4aS,5aS,6S,12aR)-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide

InChIKey

NWXMGUDVXFXRIG-WESIUVDSSA-N

INCHI

1S/C22H24N2O8/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28/h4-6,9-10,15,25-26,29,31-32H,7H2,1-3H3,(H2,23,30)/t9-,10-,15-,21+,22-/m0/s1

Isomeric SMILES

C[C@@]1([C@H]2C[C@H]3[C@@H](C(=O)C(=C([C@]3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O

PubChem CID

54675776

Molecular Weight

444.44

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Phenylpropanoids and polyketides
    • Class Tetracyclines

• Kingdom: Organic compounds
• Superclass: Phenylpropanoids and polyketides
• Class: Tetracyclines
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Tetracyclines
• Alternative Parents: Naphthols and derivatives Cyclohexenones Aralkylamines 1-hydroxy-4-unsubstituted benzenoids 1-hydroxy-2-unsubstituted benzenoids Vinylogous acids Tertiary alcohols Trialkylamines Cyclic alcohols and derivatives Polyols Enols Carboximidic acids Organopnictogen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic homopolycyclic compounds
• Substituents: Tetracycline - 1-naphthol - Naphthalene - 1-hydroxy-4-unsubstituted benzenoid - 1-hydroxy-2-unsubstituted benzenoid - Cyclohexenone - Aralkylamine - Benzenoid - Cyclic alcohol - Tertiary alcohol - Vinylogous acid - Ketone - Cyclic ketone - Tertiary aliphatic amine - Tertiary amine - Carboximidic acid - Carboximidic acid derivative - Enol - Polyol - Organic oxide - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Amine - Alcohol - Organonitrogen compound - Organooxygen compound - Carbonyl group - Hydrocarbon derivative - Aromatic homopolycyclic compound
• Description: This compound belongs to the class of organic compounds known as tetracyclines. These are polyketides having an octahydrotetracene-2-carboxamide skeleton, substituted with many hydroxy and other groups.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: Soluble in 1M HCl with heating；≥74.9 mg/mL in DMSO； insoluble in EtOH
• Sensitivity: Hygroscopic,Light sensitive.
• Melt Point(°C): 172-174℃
• Molecular Weight: 444.400 g/mol
• XLogP3: -2.000
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 2
• Exact Mass: 444.153 Da
• Monoisotopic Mass: 444.153 Da
• Topological Polar Surface Area: 182.000 Ų
• Heavy Atom Count: 32
• Formal Charge: 0
• Complexity: 971.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 5
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1