TMP778 - ≥97% , CAS No.1422171-08-1

CAS: 1422171-08-1 Cat. No.: T412973 Formula: C₃₁H₃₀N₂O₄ Molecular Weight: 494.58 PubChem CID: 137704642

GRADE & PURITY ≥97%

Synonyms

5-​Benzofuranacetamide,2-​[(3,​5-​dimethyl-​4-​isoxazolyl)​hydroxymethyl]​-​N-​[(S)​-​(2,​4-​dimethylphenyl)​phenylmethyl]​-

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Information

TMP778 TMP778 is a selective inhibitor of RORγt with an IC50 of 5 nM in the Fluorescence Resonance Energy Transfer (FRET) assay and an IC50 of 17 nM in the RORγ assay.

Specifications

Synonyms

5-​Benzofuranacetamide,2-​[(3,​5-​dimethyl-​4-​isoxazolyl)​hydroxymethyl]​-​N-​[(S)​-​(2,​4-​dimethylphenyl)​phenylmethyl]​-

Specifications & Purity

≥97%

Biochemical and Physiological Mechanisms

TMP778 is a selective inhibitor of RORγt with an IC50 of 5 nM in the Fluorescence Resonance Energy Transfer (FRET) assay and an IC50 of 17 nM in the RORγ assay.

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥97%

Names and Identifiers

• Pubchem Sid: 528767420
• Canonical Smiles: CC1=CC(=C(C=C1)C(C2=CC=CC=C2)NC(=O)CC3=CC4=C(C=C3)OC(=C4)C(C5=C(ON=C5C)C)O)C
• IUPAC Name: 2-[2-[(3,5-dimethyl-1,2-oxazol-4-yl)-hydroxymethyl]-1-benzofuran-5-yl]-N-[(R)-(2,4-dimethylphenyl)-phenylmethyl]acetamide
• InChIKey: DIURRJOJDQOMFC-PBBFAOSKSA-N
• INCHI: 1S/C31H30N2O4/c1-18-10-12-25(19(2)14-18)30(23-8-6-5-7-9-23)32-28(34)16-22-11-13-26-24(15-22)17-27(36-26)31(35)29-20(3)33-37-21(29)4/h5-15,17,30-31,35H,16H2,1-4H3,(H,32,34)/t30-,31?/m1/s1
• PubChem CID: 137704642
• Molecular Weight: 494.58

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro DMSO: 99 mg/mL (200.16 mM); Ethanol: 99 mg/mL (200.16 mM); Water: Insoluble