TMP920 - 10mM in DMSO , CAS No.1421837-45-7

CAS: 1421837-45-7 Cat. No.: T655202 Molecular Weight: 454.56

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

TMP920 is a highly potent and selective RORγt antagonist. TMP920 inhibits RORγt binding to the SRC1 peptide with an IC 50 of 0.03 μM

In Vitro

TMP920 (0.09-30 μM) starts to show toxic effects on cell growth at >10 μM in Naïve CD4 + T cells. TMP920 suppresses Th17 cell differentiation and lost its IL-17 inhibitory effect at <2.5 μM in vitro. TMP920 suppresses IL-17 production from differentiated Th17 cells in vitro. TMP920 suppresses the Th17 cell transcriptome and promotes alternate T-cell subsets. TMP920 significantly reduces RORγt-DNA interactions. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Cytotoxicity AssayCell Line: Naïve CD4 + T cells Concentration: 0.09-30 μM Incubation Time: 48 hours Result: Has toxic effects on cell growth at >10 μM.

IC50& Target:IC50: 0.03 μM (RORγt)

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

TMP920 is a highly potent and selective RORγt antagonist. TMP920 inhibits RORγt binding to the SRC1 peptide with an IC 50 of 0.03 μM.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Molecular Weight: 454.56