Native Rat Transferrin Protein, CAS No.11096-37-0

CAS: 11096-37-0 Cat. No.: np001009

GRADE & PURITY Carrier Free, ≥95%(SDS-PAGE), from Rat serum; Protein concentration: See COA

Accession #

P12346

Overview

Transferrin is a single polypeptide chain glycoprotein and is a member of the iron binding family of proteins. It has a molecular weight of 77 kDa and a serum concentration range of 1800 to 2700 mg/L. It is synthesized in the liver and consists of two domains each having a high affinity reversible binding site for Fe³⁺. Iron is transported in blood and interstitial fluids to sites of use and disposal. Iron/transferrin is essential in hemoglobin synthesis and for certain types of cell division. Serum concentration rises in iron deficiency and pregnancy and falls in iron overload, infection and inflammatory conditions. The function of transferrin is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. In addition to its function in iron transport, this protein may also have a physiologic role as granulocyte/pollen binding protein (GPBP) involved in the removal of certain organic matter/allergens from serum.

Specifications

Product Name

Native Rat Transferrin Protein, CAS No.11096-37-0

Synonyms

Rat Transferrin | Transferrin, Rat | Transferrin from Rat serum | Serotransferrin | Beta-1 metal-binding globulin | Siderophilin | Tf | Tfn | Trf

Grade

Carrier Free

Specifications & Purity

Carrier Free, ≥95%(SDS-PAGE), from Rat serum; Protein concentration: See COA

Biochemical and Physiological Mechanisms

Transferrins are iron binding transport proteins which can bind two Fe3+ ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage a

Accession #

P12346

Predicted molecular weight

77 kDa

CAS

11096-37-0

Molecule Type

Protein

Product Properties

• ALogP: -2.5

Storage and Shipping

Shape

Lyophilized

Concentration

from Rat serum; Protein concentration: See COA

Storage

Store at -20°C,Avoid repeated freezing and thawing

Shipped In

Ice chest + Ice pads

Stability And Storage

Store at -20°C or -80°C long term (6 months). Upon receipt, it is recommended to aliquot.

References

1. Qi Jia, Shuangshuang Zhang, Dan Wang, Jianqiang Liu, Xinhui Luo, Yu Liu, Xin Li, Fuliang Sun, Guangjun Xia, Lichun Zhang.  (2023)  Regulatory Effects of FGF9 on Dermal Papilla Cell Proliferation in Small-Tailed Han Sheep.  Genes,  14  (5): (1106).  [PMID:37239467] [10.3390/genes14051106]

2. Tongtong Hou, Xu Shao, Minling Ding, Kun Mei, Xin Wang, Ping Guan, Xiaoling Hu.  (2023)  Photooxidative inhibition and decomposition of β-amyloid in Alzheimer's by nano-assemblies of transferrin and indocyanine green.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:37086772] [10.1016/j.ijbiomac.2023.124432]

3. Shiwei Liu, Shuang Han, Yuzhuo Song, Ruonan Sun, Le Zhao, Chen Yan.  (2023)  Disulfide-Bridged Dendritic Organosilicas-Based Biodegradable Molecularly Imprinted Polymers for Multiple Targeting and pH/Redox-Responsive Drug Release toward Chemical/Photodynamic Synergistic Tumor Therapy.  Advanced Healthcare Materials,  12  (20): (2300184).  [PMID:36943098] [10.1002/adhm.202300184]

4. Fei Qu, Zhuo Wang, Cong Li, Dafeng Jiang, Xian-en Zhao.  (2022)  Peptide cleavage-mediated aggregation-enhanced emission from metal nanoclusters for detecting trypsin and screen its inhibitors from foods.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2022.131610]

5. Ji Feng, Shuai Chen, Yong-Liang Yu, Jian-Hua Wang.  (2020)  Red-emission hydrophobic porphyrin structure carbon dots linked with transferrin for cell imaging.  TALANTA,      [PMID:32498886] [10.1016/j.talanta.2020.121014]

6. Yameng Han, Tianyu Chen, Yiliang Li, Langxing Chen, Lin Wei, Lehui Xiao.  (2019)  Single-Particle Enumeration-Based Sensitive Glutathione S-Transferase Assay with Fluorescent Conjugated Polymer Nanoparticle.  ANALYTICAL CHEMISTRY,      [PMID:31402640] [10.1021/acs.analchem.9b01849]

7. Wei Chen, Min Fu, Xixi Zhu, Qingyun Liu.  (2019)  A close-packed imprinted colloidal array for naked-eye detection of glycoproteins under physiological pH.  BIOSENSORS & BIOELECTRONICS,      [PMID:31306955] [10.1016/j.bios.2019.111499]

8. Qiao Juan, Liu Qianrong, Wu Han, Cai Huiwu, Qi Li.  (2019)  Non-enzymatic detection of serum glucose using a fluorescent nanopolymer probe.  MICROCHIMICA ACTA,  186  (6): (1-7).  [PMID:31114937] [10.1007/s00604-019-3475-9]

9. Xiaoting Xue, Rui Lu, Min Liu, Yi Li, Jiansheng Li, Lianjun Wang.  (2018)  A facile and general approach for the preparation of boronic acid-functionalized magnetic nanoparticles for the selective enrichment of glycoproteins.  ANALYST,  144  (2): (641-648).  [PMID:30475352] [10.1039/C8AN01704B]

10. Wenhui Fu, Fei Qu, Gang Yu, Jinmao You.  (2017)  High selectivity for sodium dodecyl sulphate by polymer nanoparticles and detection of proteins based on the polymer nanoparticles-sodium dodecyl sulphate system.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2017.01.175]

11. Fei Qu, Xinyu Guo, Dongya Liu, Guang Chen, Jinmao You.  (2016)  Dual-emission carbon nanodots as a ratiometric nanosensor for the detection of glucose and glucose oxidase.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2016.04.085]

12. Fei Qu, Dongya Liu, Jinmao You.  (2016)  Fluorescent turn-off/on bioassay for hemoglobin based on dual-emission carbon nanodots-graphene oxide system with multi-detection strategies.  ANALYTICA CHIMICA ACTA,      [PMID:27126790] [10.1016/j.aca.2016.03.048]

13. Jia Hao, Shaohui Beng, Zifeng Ma, Hongmei Xu, Ting Yang, Qiman Yang, Yunduan Wang, Wenhui Zheng, Yisha Ma, Shuo Zhang, Liangde Kuang, Wei Fu.  (2024)  Short-Term Exposure of Bisphenol A Deteriorates the Quality of Rabbit Milk by Impairing Milk Fat Synthesis.  Food Science & Nutrition,      [PMID:39723079] [10.1002/fsn3.4561]

14. Ma Zifeng, Li Qiao, Xu Hongmei, Li Yueyue, Wang Shujin, Xiong Yan, Lan Daoliang, Li Jian, Xiong Xianrong, Fu Wei.  (2024)  Zearalenone Triggers Programmed Cell Death and Impairs Milk Fat Synthesis via the AKT-mTOR-PPARγ-ACSL4 Pathway in Bovine Mammary Epithelial Cells.  JOURNAL OF ANIMAL SCIENCE,      [PMID:39285681] [10.1093/jas/skae276]

15. Yinuo Yuan, Liya Tian, Xinyu Liu, Kai Guo, Ke Ren, Lei Yan, Mengyao Mu, Shangui Liu, Feifei Teng, Cun Liu, Ping Liang, Xiao Sun.  (2025)  Transferrin-Targeted Nanoarchitectonics with Efficient Metastasis Inhibition Enabling Tumor T1-T2 Dual-Mode Magnetic Resonance Contrast Enhancement.  Advanced Healthcare Materials,      [PMID:40693301] [10.1002/adhm.202500690]

16. Mengjun Wang, Linyu Nian, Shuo Zhang, Yan Zeng, Wei Man, Xiaoyang Sun, Suilou Wang, Chongjiang Cao.  (2025)  Probiotics Behavior-Inspired Biomimetic Platform for Ulcerative Colitis Prevention and Therapy.  ADVANCED FUNCTIONAL MATERIALS,      [PMID:] [10.1002/adfm.202505817]

17. Kaimin Gong, Xiaofei Wang, Yunfeng Bai, Xueqin Ma, Guoning Chen.  (2025)  Preparation of In-Situ Multifunctional Silicon Self-Assembled Molecularly Imprinted Polymers for Selective Extraction of Protein.  JOURNAL OF SEPARATION SCIENCE,  48  (10): (e70291).  [PMID:41057285] [10.1002/jssc.70291]

18. Yan Hao, Zhendong Jiang, Yanxin Lu, Bin Zhou.  (2025)  Dual electrochemiluminescence signal sensor for simultaneous analysis of multiple tuberculosis biomarkers.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2025.115711]

19. Yanbing Song, Zhuo Zhao, Yuxuan Wang, Ran Cheng, Yafei Wang, Yan Zhang, Ying Guan, Yongjun Zhang.  (2026)  Rational Engineering of Copper Ion-Coordinated Molecularly Imprinted Polymers for Synergistic Enhancement of Protein Recognition and Separation.  LANGMUIR,      [PMID:41661287] [10.1021/acs.langmuir.5c05246]