TRV-120027 TFA - ≥98% , CAS No.T658767

CAS: T658767 Cat. No.: T658767 Formula: C₄₅H₆₈F₃N₁₃O₁₂ Molecular Weight: 1040.1

GRADE & PURITY ≥98%

Storage

Protected from light,Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

TRV120027 TFA, a β-arrestin-1 -biased agonist of the angiotensin II receptor type 1 (AT1R) , engages ß-arrestins while blocking G-protein signaling. TRV120027 TFA induces acute catecholamine secretion through cation channel subfamily C3 (TRPC3) coupl

Appearance:Solid

IC50& Target:IC50: the angiotensin II receptor type 1 (AT1R)

In Vitro:TRV120027 TFA (100 nM) significantly increases the AT1R and TRPC3 association with the immunoprecipitated β-arrestin-1 in HEK293 cells co-transfected with Flag-AT1R-cherry, HA-β-arrestin-1 and TRPC3-GFP. TRV120027 TFA (100 nM) induces an [Ca 2+ ]i in

In Vivo:TRV120027 TFA (intravenous injection; 0.3 or 1.5 µg/kg per minute; infusion rate, 0.5 mL/min) when added to furosemide decreases cardiac preload and afterload, systemic and renal vascular resistances, and left ventricular external work while increasing ca

Biological Activity:TRV120027 TFA, a β-arrestin-1 -biased agonist of the angiotensin II receptor type 1 (AT1R) , engages ß-arrestins while blocking G-protein signaling . TRV120027xa0TFA inducesxa0acutexa0catecholaminexa0secretionxa0through cation channel subfamily C3 (TR

Specifications

Specifications & Purity

≥98%

Storage

Protected from light,Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Names and Identifiers

Molecular Weight

1040.1

Chemical and Physical Properties

• Solubility: DMSO : 100 mg/mL (96.14 mM; Need ultrasonic)

Frequently Asked Questions

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?80 °C, protected from light, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is T658767, the molecular formula is C45H68F3N13O12, and the molecular weight is 1040.1 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.