Tyk2-IN-7 , CAS No.1609391-90-3

CAS: 1609391-90-3 Cat. No.: T650258 Formula: C₁₈H₁₅D₃N₆O₃S Molecular Weight: 401.46

Storage

Store at 2-8°C,Protected from light,Desiccated

Shipped In

Wet ice

Overview

Tyk2-IN-7 is a TYK2 JH2 inhibitor, binds to TYK2 JH2 domain with IC50 and Ki.app of 0.00053 μM and 0.00007 μM, respectively. Tyk2-IN-7 provides a highly selective alternative to conventional TYK2 orthosteric inhibitors, inhibits TYK2/JAK1/JAK2 kinase domain. Tyk2-IN-7 provides robust inhibition in a mouse IL-12-induced IFNγ pharmacodynamic model as well as efficacy in an IL-23 and IL-12-dependent mouse colitis model.

Form:Solid

IC50& Target:Tyk2 JH2 0.00053 μM (IC 50 ) Tyk2 JH2 0.00007 μM (Ki app)

Specifications

Biochemical and Physiological Mechanisms

Tyk2-IN-7 is a TYK2 JH2 inhibitor, binds to TYK2 JH2 domain with IC50 and Ki.app of 0.00053 μM and 0.00007 μM, respectively. Tyk2-IN-7 provides a highly selective alternative to conventional TYK2 orthosteric inhibitors, inhibits TYK2/JAK1/JAK2 kinase doma

Storage

Store at 2-8°C,Protected from light,Desiccated

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

Canonical Smiles

O=C(NC([2H])([2H])[2H])C1=NN=C(NC2=CC=CC=N2)C=C1NC3=CC=CC=C3S(=O)(C)=O

Molecular Weight

401.46

Chemical and Physical Properties

• Solubility: DMSO : 100 mg/mL (249.09 mM; Need ultrasonic)

Frequently Asked Questions

How should this product be stored?

Store at 2–8 °C, protected from light, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1609391-90-3, the molecular formula is C18H15D3N6O3S, and the molecular weight is 401.46 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.