UZH1 - ≥99% , CAS No.U658781

CAS: U658781 Cat. No.: U658781 Molecular Weight: 558.71

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

UZH1 is a racemate of UZH1a and UZH1b. UZH1a is a potent and selective METTL3 inhibitor, with an IC 50 of 280 nM. UZH1b (IC 50 =28 µM) is essentially inactive. UZH1 can be used for epitranscriptomic modulation of cellular processes. UZH1 has antitumor act

Appearance:Solid

In Vitro:UZH1a (2.5-160 µM; 72 h) inhibits the growth of MOLM-13, HEK293T, and U2Os cells, with IC 50 s of 11 µM, 67 µM, and 87 µM, respectively. UZH1b (2.5-160 µM; 72 h) inhibits the growth of MOLM-13, HEK293T, and U2Os cells, with IC 50 s of 78 µM, 79 µM, a

Biological Activity:UZH1 is a racemate of UZH1a and UZH1b. UZH1a is a potent and selective METTL3 inhibitor, with an IC 50 of 280 nM. UZH1b (IC 50 =28 µM) is essentially inactive. UZH1 can be used for epitranscriptomic modulation of cellular processes. UZH1 has antitumor act

Specifications

Specifications & Purity

≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥99%

Names and Identifiers

• Canonical Smiles: O=C(NCC1(O)CN(C2=NC=NC(NCC3=CC=CC=C3)=C2)CCC1)C4=CC=C(CN5CCC(C)(C)CC5)C=C4O
• Molecular Weight: 558.71

Chemical and Physical Properties

• Solubility: DMSO : 125 mg/mL (223.73 mM; Need ultrasonic)