VUF 10166 - 10mM in DMSO , CAS No.155584-74-0

CAS: 155584-74-0 Cat. No.: V407864 Formula: C₁₃H₁₅ClN₄ Molecular Weight: 262.74 PubChem CID: 24278976

GRADE & PURITY 10mM in DMSO

Synonyms

Quinoxaline, 2-chloro-3-(4-methyl-1-piperazinyl)-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

VUF10166 is a novel, potent and competitive antagonist for5-HT3Areceptor withKiof 0.04 nM, its affinity at 5-HT3AB receptor is significantly lower.
In vitro

VUF10166 shows low activity to 5-HT₃AB receptor with K_i of 22 nM. VUF10166 may be used to can distinguish between 5-HT₃A and 5-HT₃AB receptors. VUF10166 has no activity to α7 nACh receptor. VUF10166 also acts as a partial agonist at 5-HT3A receptors with EC50 of 5.2 μM, which shows that VUF10166 is unlikely to bind in the receptor pore.

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

Quinoxaline, 2-chloro-3-(4-methyl-1-piperazinyl)-

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

VUF10166 is a novel, potent and competitive antagonist for 5-HT3A receptor with K_i of 0.04 nM, its affinity at 5-HT3AB receptor is significantly lower.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Isomeric SMILES: CN1CCN(CC1)C2=NC3=CC=CC=C3N=C2Cl
• PubChem CID: 24278976
• Molecular Weight: 262.74

Associated Targets(Human)

HTR3A Tclin 5-hydroxytryptamine receptor 3A (1 Activities)

Discover Target: HTR3A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro DMSO: 36 mg/mL (199.7 mM); Ethanol: 7 mg/mL (38.83 mM); Water: Insoluble

Frequently Asked Questions

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 155584-74-0, the molecular formula is C13H15ClN4, and the molecular weight is 262.74 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.