Diethylamine - Standard for GC, ≥99.5%(GC) , CAS No.109-89-7

CAS: 109-89-7 Cat. No.: D110465 Molecular Weight: 73.14 Beilstein Registry Number: 605268 EC Number: 203-716-3
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GRADE & PURITY Standard for GC ? GC reference standard — characterized compound for calibrating GC methods. Use to build calibration curves and verify GC quantitation. ≥99.5%(GC)
Synonyms
DIETHYLAMINE|N-Ethylethanamine|109-89-7|N,N-Diethylamine|Diethamine|Ethanamine, N-ethyl-|Diaethylamin|Dietilamina|Dwuetyloamina|diethyl amine|Diethyl-amine|Et2NH|CCRIS 4792|HSDB 524|(C2H5)2NH|Diethylamine-d11|EINECS 203-716-3|UNII-B035PIS86W|B035PIS86W|DT
Storage
Room temperature
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Qty
5ml
D110465-5ml
5

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Why this grade

Standard for GC, ≥99.5%(GC) Standard for GC for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Room temperature Ships FedEx DG Service Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 105 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

Synonyms
DIETHYLAMINE | N-Ethylethanamine | 109-89-7 | N, N-Diethylamine | Diethamine | Ethanamine, N-ethyl- | Diaethylamin | Dietilamina | Dwuetyloamina | diethyl amine | Diethyl-amine | Et2NH | CCRIS 4792 | HSDB 524 | (C2H5)2NH | Diethylamine-d11 | EINECS 203-716-3 | UNII-B035PIS86W | B035PIS86W | DT
Specifications & Purity
Standard for GC, ≥99.5%(GC)
Storage
Room temperature
Shipped In
FedEx DG Service
This product requires cold chain shipping. Ground and other economy services are not available.
Grade
Standard for GC
Purity
≥99.5%(GC)
Names and Identifiers
Canonical SmilesCCNCC
IUPAC NameN-ethylethanamine
InChIKeyHPNMFZURTQLUMO-UHFFFAOYSA-N
INCHI1S/C4H11N/c1-3-5-4-2/h5H,3-4H2,1-2H3
Isomeric SMILES CCNCC
WGK Germany 1
RTECS HZ8750000
UN Number 1154
Packing Group II
Molecular Weight 73.14
Beilstein 605268
Reaxy-Rn 605268
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=605268&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

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✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

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📊 Datasheet

Quick-reference summary of product specifications and applications.

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🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

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Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganic nitrogen compounds
ClassOrganonitrogen compounds
SubclassAmines
Intermediate Tree Nodes Secondary amines
Direct ParentDialkylamines
Alternative Parents Organopnictogen compounds  Hydrocarbon derivatives  
Molecular FrameworkAliphatic acyclic compounds
Substituents Secondary aliphatic amine - Organopnictogen compound - Hydrocarbon derivative - Aliphatic acyclic compound
DescriptionThis compound belongs to the class of organic compounds known as dialkylamines. These are organic compounds containing a dialkylamine group, characterized by two alkyl groups bonded to the amino nitrogen.
External Descriptors secondary aliphatic amine
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
CXCL8 Tchem Interleukin-8 (642 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TP53 Tchem Cellular tumor antigen p53 (48468 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot NumberCertificate TypeDateItem
G2327344Certificate of AnalysisAug 01, 2023 D110465
J2111396Certificate of AnalysisJul 06, 2023 D110465
D2108161Certificate of AnalysisJan 15, 2023 D110465
Chemical and Physical Properties
SolubilitySoluble in water, alcohol, and ether.
SensitivityAir Sensitive
Refractive Index1.385
Flash Point(°F)-14.8 °F - closed cup
Flash Point(°C)-26 °C - closed cup
Boil Point(°C)55 °C (lit.)
Melt Point(°C)-50 °C (lit.)
Molecular Weight73.140 g/mol
XLogP30.600
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count1
Rotatable Bond Count2
Exact Mass73.0891 Da
Monoisotopic Mass73.0891 Da
Topological Polar Surface Area12.000 Ų
Heavy Atom Count5
Formal Charge0
Complexity11.100
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Documents & Articles
Citations of This Product
References
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61. Xiaolei Qian, Hua Fan, Chaozhan Wang, Yinmao Wei.  (2013)  Preparation of high-capacity, weak anion-exchange membranes by surface-initiated atom transfer radical polymerization of poly(glycidyl methacrylate) and subsequent derivatization with diethylamine.  APPLIED SURFACE SCIENCE,      [PMID:] [10.1016/j.apsusc.2013.01.167]
62. Li Yongqiang, Yang Siwei, Bao Wancheng, Tao Quan, Jiang Xiuyun, Li Jipeng, He Peng, Wang Gang, Qi Kai, Dong Hui, Ding Guqiao, Xie Xiaoming.  (2024)  Accelerated proton dissociation in an excited state induces superacidic microenvironments around graphene quantum dots.  Nature Communications,  15  (1): (1-13).  [PMID:39103388] [10.1038/s41467-024-50982-x]
63. Yafeng Huang, Xuan Tian, Jinfei Wang, Kejun Zhong, Yuan Chen, Chenglong Li, Pengxiang Jia.  (2024)  Bioinspired Fabrication of an Insensitive Ammonium Perchlorate Core–Shell Composite with Polydopamine Coating.  Polymers,  16  (8): (1069).  [PMID:38674989] [10.3390/polym16081069]
64. Fujun Li, Peihao Cheng, Xinghai Li, Yun Zou, Shengyang Tao.  (2024)  Continuous-Flow Photobromination/Debromination Cascade for Synthesis of the Trifloxystrobin Intermediate.  INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH,      [PMID:] [10.1021/acs.iecr.4c02202]
65. Jianfeng Yang, Hongyi Jiang, Congcong Wu, Yuzhe Lin, Guancan Tan, Juannan Zhan, Lijiang Han, Yiting Zhu, Ping Shang, Liangle Liu, Haixiao Liu.  (2025)  Copper silicate nanoparticle-mediated delivery of astragaloside-IV for osteoarthritis treatment by remodeling the articular cartilage microenvironment.  JOURNAL OF CONTROLLED RELEASE,      [PMID:40032006] [10.1016/j.jconrel.2025.113583]
66. Xiaojun Chu, Xianlong Wang, Ranran Wei, Min Yan, Xuewen Wei, Xiaoying Zhang, Zhaoyou Zhu, Yinglong Wang, Liang Wang, Shuli Yin.  (2024)  Defect-rich PdCo bimetallene constructed by a self-reduction strategy for enhanced ethanol oxidation reaction.  Materials Today Physics,      [PMID:] [10.1016/j.mtphys.2024.101416]
67. Quanhua Wang, Weijiong Dai, Yi Dai, Meng Pan, Yanchao Liu, Lichen Zhang, Jiajun Zheng, Xuguang Liu, Ruifeng Li, Luoning Ma, Hu Wang, Yuhao Zong.  (2024)  Design Synthesis of Low-Silica SAPO-34 Nanocrystals by Constructing Isomorphous Core–Shell Structure: An Effective Catalyst for Improving Catalytic Performances in Methanol-to-Olefins Reaction.  ACS Applied Materials & Interfaces,      [PMID:38456610] [10.1021/acsami.3c19166]
68. Yu Shen, Liu Zhan, Lyu Jia-Min, Guo Chun-Mu, Yu Yang Xiao-, Jiang Peng, Wang Yi-Long, Hu Zhi-Yi, Sun Ming-Hui, Li Yu, Chen Li-Hua, Su Bao-Lian.  (2024)  Engineering surface framework TiO6 single sites for unprecedented deep oxidative desulfurization.  National Science Review,      [PMID:38577670] [10.1093/nsr/nwae085]
69. Qianchun Zhang, Xixi Long, Shan Tang, Li Jiang, Zhaoru Ban, Yanju Chen, Runkun Zhang.  (2024)  Enhanced Cataluminescence Sensor Based on SiO2/MIL-53(Al) for Detecting Isobutylaldehyde.  MOLECULES,      [PMID:39064866] [10.3390/molecules29143287]
70. Rui Chen, Kin Hong Ip, Xin Huang, Junhong Li, Zhiliang Dong, Men Shao, Min Xu, Weiyi Yang, Tingting Yan, Zhidong Li, Hui Zhang, Ji Ma, Sheng’an Yang, Qingming Chen.  (2024)  Enhanced magnetoresistance properties in La0.7−xSmxCa0.3MnO3 epitaxial films.  MODERN PHYSICS LETTERS B,      [PMID:] [10.1142/S0217984924504281]
71. Lin Cheng, Si-Yu Li, Yu-Jie Zhang, Xin Meng, Ying Wang, Shuaihua Wang, Kai-Yao Wang.  (2025)  Fabricating Open-Framework Using Polyoxovanadate Clusters for Efficient Removal of Radioactive Cs+ and Sr2+.  ADVANCED FUNCTIONAL MATERIALS,      [PMID:] [10.1002/adfm.202424406]
72. Wenkai Zhao, Runxiang Tan, Yanping Yang, Haoyong Yang, Jianing Wang, Xiaodong Yin, Daheng Wu, Tao Zhang.  (2024)  Galvanic-Replacement-Assisted Synthesis of Nanostructured Silver-Surface for SERS Characterization of Two-Dimensional Polymers.  SENSORS,  24  (2): (474).  [PMID:38257565] [10.3390/s24020474]
73. Xiuzhen Zhao, Yin Cai, Jishi Chen, Aiping Fu, Fang Ge.  (2024)  Group transfer polymerization of polar conjugated monomers using pinacolborane and thiourea anions.  JOURNAL OF POLYMER SCIENCE,      [PMID:] [10.1002/pol.20240362]
74. Ling Xin, Mengxin Ren, Yanwei Lou, Huawen Yin, Feng Qin, Zhili Xiong.  (2024)  Integrated UHPLC-MS untargeted metabolomics and gut microbe metabolism pathway-targeted metabolomics to reveal the prevention mechanism of Gushudan on kidney-yang-deficiency-syndrome rats.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,      [PMID:38387127] [10.1016/j.jpba.2024.116062]
75. Meng Xu, Xiaoling Liu, Zhuo Xiong, Yue Wu, Zhen Meng, Yu Zhou, Jun Wang.  (2024)  Regulating the electronic state of MFI zeolite encapsulated Pt nanoparticles to boost the atom efficiency in reductive amination of biomass-derived furfural.  Molecular Catalysis,      [PMID:] [10.1016/j.mcat.2024.114740]
76. Shiquan Cao, Yujia Kang, Huiping Tang, Zhi Chen.  (2024)  Separation of lead-212 from natural thorium solution utilizing novel sulfonamide dibenzo-18-crown-6.  DALTON TRANSACTIONS,  53  (8): (3722-3730).  [PMID:38299333] [10.1039/D3DT04166B]
77. Liwei Hou, Xinyue Xu, Xiaoli Wang, Li Wang, Fengchun Tian, Yi Xu.  (2024)  SERS sensing chip based on Ti3C2/nano-Au@MA for ultrasensitive amine gas detection.  Journal of Materials Chemistry A,  12  (16): (9817-9829).  [PMID:] [10.1039/D4TA00429A]
78. Shengtao Dai, Fei Yan, Siyu Zhang, Jiaming Guo, Lin Zhang, Yu Liu, Liu Liu, Yuhui Ao.  (2024)  Synthesis of a fully bio-based self-catalyzed hyperbranched waterborne polyurethane as a sizing agent for enhancing the interfacial properties of CF/PA6 composites.  GREEN CHEMISTRY,      [PMID:] [10.1039/D3GC04294D]
79. Yuyi Bi, Bin Tang, Xiangyu Shen, Chuanlong Cui, Xiaoyuan Zhan, Fuzhen Bi, Xichang Bao.  (2025)  Synthesis water-dispersible silver nanoparticles based on green chemistry for inverted organic solar cells.  Materials Science and Engineering B-Advanced Functional Solid-State Materials,      [PMID:] [10.1016/j.mseb.2025.118088]
80. Wanbing Rao, Chenxia Zhang, Baolei Luan, Zhongqing Wang, Meiyan Qiu, Shaoyu Cai.  (2024)  The Development of One New Normal Phase Liquid Chromatography Method and Thermodynamic Investigation of Olodaterol Hydrochloride Enantiomer.  CHIRALITY,  36  (8): (e23704).  [PMID:39034302] [10.1002/chir.23704]
81. Li Wang, Mengzhen Yang, Ruijing Gao, Yu Pang, Xiaoshu Zhao, Guoqiang Zhou, Shutao Gao, Kun Ge, Jinchao Zhang.  (2025)  Thermal responsive nanobombs generating reactive oxygen species for synergistic anticancer therapy.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,      [PMID:39978266] [10.1016/j.jcis.2025.02.091]
82. Aofei Zhang, Xiaoyu Du, Jianglong Li, Jianlong Wen, Lang Shuai, Yongqiang Ming, Yijing Nie.  (2025)  Dynamic Synergy Effect between the Hydrogen Bond Network and Coordination Bond Network in Dual-Network Polyurethane Elastomers.  MACROMOLECULES,      [PMID:] [10.1021/acs.macromol.5c00565]
83. Mengting Zhao, Mengyun Wang, Li Jin, Boyang Cheng, Tianjiao Hou, Xuan Shen.  (2025)  Synthesis and Photocuring Properties of One-component Polymerizable Thioxanthone-based Photoinitiators with High Migration Stability.  JOURNAL OF PHOTOPOLYMER SCIENCE AND TECHNOLOGY,  38  (1): (11-19).  [PMID:] [10.2494/photopolymer.38.11]
84. Ruixiang Li, Shu Chen, Beibei Wang, Xiaodan Wang, Xinyu Hu, Sonia Estrade Albiol, Cristian Fabrega Gallego, Hao Shen, Chunhua Luo, Hui Peng, Hechun Lin.  (2025)  CuO/M(OH)₂ (M = Mg, Ca) heterostructures with in-situ oxygen vacancies enable room-temperature ultrahigh triethylamine sensing.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2025.167104]
85. Jian-Dong Wang, Qi Gu, Zi-Hui Cai, Guo-Sheng Liu, Quan Zhou, Li-Na Fu, Shi-Liang Yang, Su Zhang, Yujie Fu.  (2023)  Efficient Extraction and Mechanism Analysis of Different Polarity Phytochemicals from Rosa roxburghii by a Green CO2-Responsive Switchable Solvent Combined with Ultrasound.  ACS Sustainable Chemistry & Engineering,      [PMID:] [10.1021/acssuschemeng.3c06085]
86. Liying Zhao, Huaixia Yang, Xiaoke Zheng, Jinge Li, Lihe Jian, Weisheng Feng, Jinming Kong.  (2019)  Dual signal amplification by polysaccharide and eATRP for ultrasensitive detection of CYFRA 21–1 DNA.  BIOSENSORS & BIOELECTRONICS,      [PMID:31759763] [10.1016/j.bios.2019.111895]
87. Wang Xia, Zhang Yawen, Zhao Liying, Wang Dazhong, Yang Huaixia, Kong Jinming.  (2020)  Polysaccharide-enhanced ARGET ATRP signal amplification for ultrasensitive fluorescent detection of lung cancer CYFRA 21-1 DNA.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,  412  (11): (2413-2421).  [PMID:32047944] [10.1007/s00216-020-02394-1]
88. Zhengyi Chen, Gongke Li, Zhuomin Zhang.  (2019)  Miniaturized array gas membrane separation strategy for rapid analysis of complex samples by surface-enhanced Raman scattering.  ANALYTICA CHIMICA ACTA,      [PMID:31005148] [10.1016/j.aca.2019.03.031]
89. Yan Yan, Pengchong Wang, Ruiying Li, Ying Sun, Rui Zhang, Chuanchuan Huo, Jianfeng Xing, Yalin Dong.  (2019)  Synthesis of budesonide conjugates and their anti-inflammatory effects: a preliminary study.  Drug Design Development and Therapy,      [PMID:30858698] [10.2147/DDDT.S192348]
90. Yi Guo, Cheng Yao.  (2025)  Polyether- and Tertiary Amine-Modified Silicone Surfactants: Synthesis and Surface Performance Across pH Ranges.  Polymers,  17  (9): (1204).  [PMID:40362990] [10.3390/polym17091204]
91. Zhifan Li, Huiwei Wei, Gentao Gao, Zhiyong Deng, Shaohua Sun, Zuoye Liu, Baowei Ding, Bitao Hu, Jie Shen.  (2025)  Highly sensitive determination of lanthanides by nanochain enhanced laser-induced breakdown spectroscopy.  JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY,      [PMID:] [10.1039/D5JA00023H]
92. Qiao Zhang, Lei Yu, Yue Sun, Lixin Zang, Dazhong Shen.  (2025)  An improved differential molecularly imprinted strategy to eliminate the interference from non-specific adsorption demonstrated by a label- free electrochemiluminescence sensor for carbohydrate antigen.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2025.113891]
93. Lu Li, Saibo Liang, Juan Wei, Yilong Li, Xinyan Chen, Chaoran Lei, Guiqiang Fei.  (2025)  Polymeric photonic crystal platform for organic amines detection based on enzyme inhibition.  ANALYTICA CHIMICA ACTA,      [PMID:40480728] [10.1016/j.aca.2025.344200]
94. Shengyuan Liang, Yeyun Meng.  (2025)  Preparation of modified montmorillonite-stabilized epoxy resin emulsions and their cured properties.  NEW JOURNAL OF CHEMISTRY,      [PMID:] [10.1039/D5NJ01128K]
95. Xiu Chen, Ying Zhang, Haidong Li, Quan Shi, Suoqi Zhao, Linzhou Zhang.  (2025)  Interaction of a Vanadyl Porphyrin with Basic Amines and N-Heterocycles Ligands: A High-Resolution MS, UV–vis and DFT Study.  ENERGY & FUELS,      [PMID:] [10.1021/acs.energyfuels.5c01603]
96. Jianhui Chen, Gongwei Tian, Dan Yang, Cuiyuan Liang, Hua Liu, Ruiwen Tian, Weihong Lu, Yan Liu, Dianpeng Qi.  (2025)  Coffee Ring Effect Induced Selective Wetting of Liquid Metal for High-Resolution Stretchable Bioelectrodes.  ACS Applied Materials & Interfaces,      [PMID:40512557] [10.1021/acsami.5c06655]
97. Zixuan Zhang, Xiaogang Lu, Meng Jin, Runli Gao, Chengxin Pei, Hongmei Wang.  (2025)  A chemometric framework for forensic source apportionment of nerve agents: GC×GC-TOFMS-based signature profiling of ethyltabun (EGA) and VM.  TALANTA,      [PMID:40925116] [10.1016/j.talanta.2025.128793]
98. Jingru Liu, Zhenyu Hao, Jie Qi, Li Tong, Hongsheng Lu, Shucai Zhang.  (2025)  CO2 Switchable Solvent System Comprising Hydrophilic Deep Eutectic Solvent and N-Ethylbutylamine for Enhanced Treatment of Oily Solid Waste.  ENERGY & FUELS,      [PMID:] [10.1021/acs.energyfuels.5c04930]
99. Yi Guo, Cheng Yao.  (2025)  A Catalytically Active Tertiary Amino- and Polyether-Modified Silicone Surfactant and Its Application in Polyurethane Foams.  ACS Omega,      [PMID:41358122] [10.1021/acsomega.5c02775]
100. Zilong Liu, Wenqi Zhao, Yanxiao Hei, Yaru Xin, Fengzhi Guo, Yufei Xiao, Wenxiu Leng, Weichao Sun.  (2025)  Smart pH-responsive Pickering emulsions with high shear and salinity resistance: An experimental and simulation study.  FUEL,      [PMID:] [10.1016/j.fuel.2025.136707]
101. Li Zhang, Shanxia Jin, Xiaofeng Guo, Yi Yu, Ping Zhou.  (2026)  Laser-induced photochemical click reaction enabling on-line tagging and detection of phosphatidylethanolamine by MALDI-mass spectrometry.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2026.116916]
102. Mingming Li, Suhong Fu, Jiaxin Chen, Xinxing Sun, Yang Chen, Lei Yang.  (2026)  Ion-paired asiatic acid hydrogel facilitates high-quality wound healing through diverse synergistic effects.  JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,      [PMID:] [10.1016/j.jddst.2026.108034]
103. Qingming Kong, Yu Tan, Kaiqiang Zhang, Haiyang Zhang, Tengyang Zhu, Xu Wang.  (2026)  Dynamic decrosslinking enables self-healing, reprocessability, and upcycling in polyurethane networks.  Nature Communications,      [PMID:41495077] [10.1038/s41467-025-68263-6]
104. Siyu Guo, Xueting Ren, Xijiao Ren, Jinming He, Huocheng Yang, Wei Zhou, Menghuan Li, Lulu Wang, Yan Hu, Zhong Luo.  (2026)  Supramolecular DNA Di-Tetrahedral Neoadjuvants Dynamically Prime Melanoma Microenvironment for Enhancing Radio-Immunotherapy Responses.  ADVANCED FUNCTIONAL MATERIALS,      [PMID:] [10.1002/adfm.202524385]
105. Dong Sui, Zhanghan Shi, Zhirong Sun, Linqi Si, Wenwen Liu, Yanliang Yang, Yongsheng Zhang.  (2026)  Facile preparation of high-capacity carbon-coated SiO2 nanotubes for lithium-ion battery.  DIAMOND AND RELATED MATERIALS,      [PMID:] [10.1016/j.diamond.2026.113464]
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