2-Propylbenzo[d]thiazole: Properties, Uses & FAQs

2-Propylbenzo[d]thiazole is a sulfur- and nitrogen-containing bicyclic heterocyclic compound belonging to the benzothiazole family, widely used as a synthetic intermediate and reference standard in organic chemistry and pharmaceutical research.

Chemical Name

2-Propylbenzo[d]thiazole

SKU / Product Code

P726785

Compound Class

Benzothiazole derivative (bicyclic heterocycle containing S and N)

Core Scaffold

Benzo[d]thiazole fused ring system with n-propyl substituent at C-2

Primary Applications

Organic synthesis intermediate, pharmaceutical research, agrochemical research

Supplier

Aladdin Scientific

What Is 2-Propylbenzo[d]thiazole?

2-Propylbenzo[d]thiazole is an organosulfur heterocyclic compound featuring a benzene ring fused to a thiazole ring, with an n-propyl group attached at the 2-position of the thiazole moiety. The benzo[d]thiazole scaffold is one of the most pharmacologically important bicyclic ring systems in medicinal chemistry, appearing in numerous bioactive natural products and synthetic drug candidates.

The compound belongs to the broader class of 2-substituted benzothiazoles, which are extensively studied for their roles as synthetic building blocks and for their intrinsic biological activities. The n-propyl substitution at C-2 confers specific lipophilicity and steric characteristics compared to shorter or longer alkyl analogues, making it a useful member of structure–activity relationship (SAR) libraries.

Chemical Properties and Handling

2-Propylbenzo[d]thiazole is a liquid or low-melting solid at room temperature, as is typical for 2-alkylbenzothiazoles. It is sparingly soluble in water but readily soluble in common organic solvents such as ethanol, dichloromethane, ethyl acetate, and dimethyl sulfoxide (DMSO). The benzo[d]thiazole ring system is aromatic and relatively stable under ambient conditions, though prolonged exposure to strong oxidising agents or strong acids may degrade the compound.

Standard laboratory precautions should be observed when handling this reagent: work in a well-ventilated fume hood, wear appropriate personal protective equipment (gloves, lab coat, eye protection), and avoid inhalation or skin contact. Consult the Safety Data Sheet (SDS) provided by Aladdin Scientific for detailed hazard information before use.

Storage Conditions and Stability

To maintain the quality and integrity of 2-Propylbenzo[d]thiazole over time, the compound should be stored in a tightly sealed container away from light, heat, and moisture. Cool, dry storage conditions (typically 2–8 °C or as indicated on the product label) are recommended. Benzothiazole derivatives are generally stable when stored correctly, but repeated freeze–thaw cycles should be minimised to prevent potential degradation or changes in physical form.

Always check the certificate of analysis (CoA) supplied with each lot for the recommended storage temperature and shelf-life information specific to your batch of P726785.

Research and Synthetic Applications

2-Propylbenzo[d]thiazole serves primarily as a synthetic intermediate in the preparation of more complex heterocyclic frameworks. The 2-position of benzothiazole is a reactive site amenable to functionalization via metalation, oxidative coupling, and nucleophilic substitution strategies, allowing chemists to elaborate the propyl side chain or modify the ring system for library synthesis.

Beyond its role as a building block, 2-alkylbenzothiazoles as a class have been investigated in medicinal chemistry for potential antimicrobial, anti-inflammatory, and anticancer activities. The compound may also serve as a reference standard in analytical method development or as a flavour and fragrance reference, as certain benzothiazoles occur naturally and contribute to aroma profiles. Researchers should consult primary literature for specific biological activity data relevant to their application.

Ordering and Quality Information

2-Propylbenzo[d]thiazole is available from Aladdin Scientific under SKU P726785. Each lot is accompanied by a certificate of analysis (CoA) detailing purity, physical appearance, and analytical data. For bulk quantities, custom packaging, or specific purity requirements, contact Aladdin Scientific's sales team directly.

When placing an order, quote SKU P726785 to ensure you receive the correct compound. For questions about shipping conditions, hazardous material classification, or regulatory documentation (e.g., SDS, export compliance), refer to Aladdin Scientific's Help and Customer Service resources or contact support directly.

Frequently asked questions

What is the CAS number of 2-Propylbenzo[d]thiazole?

The CAS number for 2-Propylbenzo[d]thiazole is not specified in the current source material. Please refer to the product page for SKU P726785 on the Aladdin Scientific website or the certificate of analysis for the confirmed CAS number.

In which solvents is 2-Propylbenzo[d]thiazole soluble?

2-Propylbenzo[d]thiazole is sparingly soluble in water and readily soluble in common organic solvents including ethanol, dichloromethane, ethyl acetate, and DMSO. For stock solution preparation, DMSO or ethanol is typically recommended. Always verify solubility experimentally for your specific application conditions.

What are the recommended storage conditions for P726785?

Store 2-Propylbenzo[d]thiazole (P726785) in a tightly sealed container, protected from light and moisture, at cool temperatures (typically 2–8 °C or as indicated on the product label and CoA). Avoid repeated freeze–thaw cycles to maintain compound integrity over time.

What are the typical research applications of 2-Propylbenzo[d]thiazole?

2-Propylbenzo[d]thiazole is used primarily as a synthetic intermediate in heterocyclic chemistry and as a building block for medicinal chemistry libraries. The benzothiazole class has been explored for antimicrobial, anti-inflammatory, and anticancer properties, and the compound may also serve as a reference standard in analytical chemistry or flavour research.

How do I order 2-Propylbenzo[d]thiazole from Aladdin Scientific?

You can order 2-Propylbenzo[d]thiazole directly from the Aladdin Scientific website using SKU P726785. For bulk orders, custom specifications, or further assistance, contact the Aladdin Scientific sales or customer service team. Always quote the SKU to ensure accurate product identification.

References

1. Aladdin Scientific product page for 2-Propylbenzo[d]thiazole, SKU P726785. Aladdin Scientific.
2. General textbook knowledge on benzothiazole chemistry and 2-substituted benzothiazole derivatives. Standard organic chemistry and medicinal chemistry reference texts.

Products are supplied for research and development use only. Not for use in humans, animals, diagnosis, or therapy.