Haptoglobin from Cynomolgus Monkey Plasma: Key FAQs

Haptoglobin from Cynomolgus Monkey Plasma is a primate-derived acute-phase glycoprotein purified from plasma, designed to support hemoglobin-binding studies, comparative immunology, and preclinical research requiring non-human primate biological reagents.

Product Name

Haptoglobin from Cynomolgus Monkey Plasma

SKU

np001094

Source / Supplier Reference

Athens; lot reference 16-16-080116-CM

Biological Source

Cynomolgus Monkey (Macaca fascicularis) Plasma

Protein Class

Acute-phase glycoprotein; hemoglobin-binding protein

Intended Use

Research use only (RUO)

Product Overview

Haptoglobin from Cynomolgus Monkey Plasma (SKU: np001094) is a purified acute-phase protein sourced from Macaca fascicularis (cynomolgus monkey) plasma. The product is supplied through Athens Scientific (internal lot reference: 16-16-080116-CM) and is distributed by Aladdin Scientific for research applications. Haptoglobin is a serum glycoprotein best known for its high-affinity binding to free hemoglobin, preventing oxidative tissue damage and facilitating hemoglobin clearance via the mononuclear phagocyte system. The cynomolgus monkey is a widely used non-human primate (NHP) model in preclinical and biomedical research, making this reagent particularly valuable for translational studies where human-relevant, primate-derived proteins are required.

Biological Function and Research Relevance

Haptoglobin functions primarily as a scavenger protein in plasma, binding free hemoglobin released during intravascular or extravascular hemolysis. The haptoglobin–hemoglobin complex is subsequently recognized by the CD163 receptor on macrophages and monocytes, leading to endocytosis and lysosomal degradation, thereby recycling iron and limiting heme-induced inflammation and oxidative stress.

As an acute-phase reactant, haptoglobin concentrations rise significantly in response to infection, inflammation, and tissue injury. Cynomolgus monkey-derived haptoglobin is particularly useful in: (1) cross-reactive immunoassay validation when developing NHP-compatible ELISA or multiplex assays; (2) comparative studies of haptoglobin polymorphism and function across species; (3) preclinical hemolysis monitoring in NHP toxicology studies; and (4) serving as a species-matched positive control or standard in biomarker research.

Storage, Handling, and Stability

Proper storage and handling are essential to maintain the biological activity and integrity of haptoglobin preparations. The following general guidelines apply to plasma-purified proteins of this class; researchers should always refer to the Certificate of Analysis (CoA) supplied with each lot for lot-specific recommendations:

• Short-term storage: Store at 2–8 °C if the product will be used within the recommended short-term period specified on the CoA.
• Long-term storage: Aliquot and store at −20 °C or −80 °C to avoid repeated freeze-thaw cycles, which can lead to protein aggregation and loss of hemoglobin-binding activity.
• Avoid: Repeated freeze-thaw cycles; prolonged exposure to temperatures above 8 °C; detergent contamination.
• Reconstitution: If supplied lyophilized, reconstitute in the buffer specified on the CoA and allow the solution to equilibrate gently without vortexing.

Note: Specific storage temperature, formulation, and expiry data must be confirmed from the product CoA. Contact Aladdin Scientific technical support for lot-specific documentation.

Ordering, Documentation, and Regulatory Information

How to order: Haptoglobin from Cynomolgus Monkey Plasma (np001094) can be ordered directly through the Aladdin Scientific website or by contacting your regional sales representative. Bulk quantities and custom lot reservations may be available upon request.

Documentation provided: Each shipment is accompanied by a Certificate of Analysis (CoA) detailing purity, lot number, source species, recommended storage conditions, and quality control data. Safety Data Sheets (SDS) are available on the Aladdin Scientific website product page.

Regulatory status: This product is for Research Use Only (RUO) and is not intended for diagnostic, therapeutic, or clinical use in humans or animals.

Export and compliance: As a biological reagent derived from non-human primate plasma, importation and use may be subject to local regulations. Customers are responsible for ensuring compliance with all applicable local, national, and international regulations governing the receipt and use of NHP-derived materials.

Frequently asked questions

What is the biological source of this haptoglobin product?

The haptoglobin (np001094) is purified from the plasma of Cynomolgus Monkeys (Macaca fascicularis). The product is sourced from Athens Scientific, with internal lot reference 16-16-080116-CM, and is distributed by Aladdin Scientific.

What are the primary research applications for Cynomolgus Monkey Haptoglobin?

This product is primarily used as a species-matched reagent in non-human primate (NHP) research, including cross-reactive immunoassay development and validation, hemolysis biomarker studies in preclinical toxicology, comparative haptoglobin functional assays, and as a positive control or standard in NHP-compatible ELISA platforms. It is intended for research use only.

How should Haptoglobin from Cynomolgus Monkey Plasma be stored?

For short-term use, store at 2–8 °C. For long-term storage, aliquot and store at −20 °C or −80 °C to prevent loss of activity from repeated freeze-thaw cycles. Always consult the Certificate of Analysis provided with your specific lot for authoritative storage and stability guidance.

Is this product suitable for use in human diagnostic assays?

No. Haptoglobin from Cynomolgus Monkey Plasma (np001094) is classified as Research Use Only (RUO) and is not approved or intended for human or veterinary diagnostic, therapeutic, or clinical applications.

How do I obtain the Certificate of Analysis (CoA) or Safety Data Sheet (SDS) for this product?

The Certificate of Analysis is shipped with each product lot and can also be requested by contacting Aladdin Scientific customer service with your lot number. The Safety Data Sheet is available for download on the product page of the Aladdin Scientific website.

Can I order a custom lot or bulk quantity of this haptoglobin?

Custom lot reservations and bulk quantity inquiries may be accommodated. Please contact your regional Aladdin Scientific sales representative or reach out through the website inquiry form to discuss your specific requirements, including quantity, timeline, and any special documentation needs.

References

1. Athens Scientific product reference: Haptoglobin from Cynomolgus Monkey Plasma, lot 16-16-080116-CM. Distributed by Aladdin Scientific (np001094).
2. Graversen JH, Madsen M, Moestrup SK. CD163: a signal receptor scavenging haptoglobin-hemoglobin complexes from plasma. International Journal of Biochemistry and Cell Biology. 2002;34(4):309-314. doi:10.1016/S1357-2725(01)00120-4
3. Dobryszycka W. Biological functions of haptoglobin — new pieces to an old puzzle. European Journal of Clinical Chemistry and Clinical Biochemistry. 1997;35(9):647-654. PMID:9352226

Products are supplied for research and development use only. Not for use in humans, animals, diagnosis, or therapy.