N-(4-Methoxyphenyl)propionamide: Properties & Lab FAQ

N-(4-Methoxyphenyl)propionamide is an aryl amide compound used as a chemical intermediate and reference standard in organic synthesis and analytical research applications.

Chemical Name

N-(4-Methoxyphenyl)propionamide

Also Known As

4-Methoxypropionanilide; p-Methoxypropionanilide

Molecular Formula

C₁₀H₁₃NO₂

Molecular Weight

179.22 g/mol

CAS Number

needs_review — not confirmed in source material

SKU / Catalog Number

N697882

Supplier

Aladdin Scientific

What Is N-(4-Methoxyphenyl)propionamide?

N-(4-Methoxyphenyl)propionamide, also referred to as 4-methoxypropionanilide or p-methoxypropionanilide, is an aromatic amide formed by the condensation of 4-methoxyaniline (p-anisidine) with propionic acid or propionyl chloride. It belongs to the class of N-aryl amides, which are widely employed as intermediates in the preparation of pharmaceuticals, agrochemicals, and specialty organic compounds.

The compound features a para-methoxy substituent on the phenyl ring, which modulates the electron density of the aromatic system and the reactivity of the amide nitrogen. These structural characteristics make it a useful building block in multi-step synthetic routes.

Physicochemical Properties and Handling

N-(4-Methoxyphenyl)propionamide is typically a white to off-white crystalline solid at room temperature. Its aromatic amide backbone confers moderate thermal stability. Key physicochemical parameters such as exact melting point, solubility profile, and log P should be verified against the certificate of analysis (CoA) supplied with each lot, as these values may vary with purity grade.

General handling precautions applicable to aryl amide reagents should be observed: wear appropriate personal protective equipment (PPE) including gloves, lab coat, and eye protection; avoid inhalation of dust; and handle in a well-ventilated fume hood. Consult the Safety Data Sheet (SDS) provided by Aladdin Scientific before use.

Storage Conditions and Shelf Life

As with most solid aryl amides, N-(4-Methoxyphenyl)propionamide should be stored in a tightly sealed container, away from moisture, heat, and direct light. A cool, dry storage environment — typically room temperature or refrigerated (2–8 °C) depending on the grade — is recommended to maintain reagent integrity over time.

Always refer to the product label and CoA for lot-specific storage instructions provided by Aladdin Scientific. Do not use the reagent beyond the expiry date printed on the label.

Typical Research Applications

N-(4-Methoxyphenyl)propionamide serves primarily as a synthetic intermediate in organic chemistry. Aryl amides of this structural class are commonly encountered in:

• Pharmaceutical intermediate synthesis: The methoxyphenyl amide motif appears in various drug discovery programs targeting enzyme inhibition and receptor modulation.
• Analytical reference standards: High-purity batches may be used as reference compounds in HPLC, LC-MS, or NMR method development and validation.
• Chemical biology research: Used to probe structure–activity relationships (SAR) when systematic variation of the N-acyl chain or ring substituent is required.

Specific application details and literature precedents should be confirmed by the end user in peer-reviewed publications relevant to their research program.

Ordering, Purity Grades, and Quality Assurance

Aladdin Scientific supplies N-(4-Methoxyphenyl)propionamide under catalog number N697882. Researchers should confirm available pack sizes, purity specifications, and current stock status through the Aladdin Scientific website or by contacting customer service directly.

Each lot is accompanied by a Certificate of Analysis (CoA) documenting purity (typically assessed by HPLC or titration), appearance, and other quality parameters. If your application demands a specific purity threshold (e.g., ≥98% for reference standard use), please verify the CoA data prior to placing an order. Bulk quantities and custom purity grades may be available upon request.

Frequently asked questions

What is the catalog number for N-(4-Methoxyphenyl)propionamide at Aladdin Scientific?

The catalog number (SKU) for N-(4-Methoxyphenyl)propionamide at Aladdin Scientific is N697882. You can search this SKU directly on the Aladdin Scientific website to check current availability, pricing, and pack sizes.

What purity grade of N-(4-Methoxyphenyl)propionamide does Aladdin Scientific offer?

Purity specifications vary by lot and are confirmed in the Certificate of Analysis (CoA) accompanying each shipment. Please check the product page for N697882 on the Aladdin Scientific website or contact customer service for the current purity grade and to request a CoA before purchase.

How should N-(4-Methoxyphenyl)propionamide be stored to maintain stability?

Store N-(4-Methoxyphenyl)propionamide in a tightly sealed container in a cool, dry place, protected from moisture, heat, and direct light. Refer to the product label and SDS for lot-specific recommendations, as refrigerated storage (2–8 °C) may be advised for certain grades.

What solvents are typically used to dissolve N-(4-Methoxyphenyl)propionamide?

Aryl amides of this structural class are generally soluble in common organic solvents such as dichloromethane, ethyl acetate, dimethyl sulfoxide (DMSO), and methanol. Solubility in aqueous media is expected to be low due to the hydrophobic methoxyphenyl group. Exact solubility data should be confirmed experimentally or via the CoA.

Can N-(4-Methoxyphenyl)propionamide be used as an analytical reference standard?

High-purity batches of N-(4-Methoxyphenyl)propionamide (N697882) may be suitable for use as reference standards in HPLC, LC-MS, or NMR analyses. Confirm the purity grade and obtain the CoA from Aladdin Scientific prior to use in validated analytical methods, ensuring it meets the acceptance criteria for your specific application.

References

1. March, J. Advanced Organic Chemistry: Reactions, Mechanisms, and Structure. Wiley-Interscience. General reference for amide bond formation and aryl amide chemistry.
2. Aladdin Scientific product page for N-(4-Methoxyphenyl)propionamide, SKU N697882. Aladdin Scientific (www.aladdin-e.com).

Products are supplied for research and development use only. Not for use in humans, animals, diagnosis, or therapy.