ferroptosis

Answers to common questions about RSL3, a potent GPX4 inhibitor used to induce ferroptosis in cancer and cell death research. Learn properties, uses, and handling.

p53 is a central transcriptional regulatory protein in the tumor-suppressor network. Its functions extend beyond DNA damage responses, cell-cycle arrest, and apoptosis to amino acid metabolism, redox homeostasis, and lipid oxidation. Ferroptosis is a form of regulated cell death driven by ...

Intracellular H₂O₂ and lipid peroxides require the coordinated action of multiple antioxidant enzyme systems for clearance. Among them, Glutathione Peroxidase (GPx), Catalase (CAT), and Peroxiredoxin (PRDX) control peroxides in different substrate and subcellular environments. GPX4 further ...

Lipid droplets (LDs) are dynamic organelles formed by a phospholipid monolayer surrounding a neutral lipid core. Their core components mainly include triacylglycerol (TAG) and cholesteryl esters. Lipid droplets are not only lipid storage structures, but also participate in energy metabolism, ...

Apoptosis is a form of programmed cell death regulated by genes and protein networks. It mainly functions to eliminate senescent, damaged, abnormally proliferating, or functionally imbalanced cells. Typical apoptosis is characterized by cell shrinkage, chromatin condensation, DNA fragmentation, ...

Oxidative stress research has shifted from the concept of “ROS excess causing damage” toward “precise regulation of redox signaling.” ROS can damage proteins, lipids, and DNA, but they can also participate in cell fate regulation, metabolic reprogramming, immune escape, and disease ...

Ferroptosis is a form of metabolic cell death jointly driven by disruption of iron homeostasis, accumulation of membrane lipid peroxidation, and failure of lipid antioxidant defense systems.