Functional Groups

Nitrogen-containing S(VI) functional groups such as sulfoximines and sulfonimidamides have attracted sustained interest in medicinal chemistry and organic synthesis in recent years. Compared with conventional sulfones and sulfonamides, these structures introduce an additional nitrogen ...

Amides are among the most common functional groups in drug molecules. They can provide hydrogen-bonding interactions, connect different structural fragments, and help molecules maintain specific conformations through their relatively strong planarity. However, an amide is not always the optimal ...

Crosslinkers are used to form covalent linkages between two molecules, or between adjacent structural elements within the same molecule. In protein experiments, crosslinkers are mainly used to address four types of tasks: capturing interactions, preparing conjugates, immobilizing proteins, and ...