Autofagia - LRRK2 Supplier | High Purity

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MLi-2, Inhibitor of leucine rich repeat kinase 2
CAS: 1627091-47-7 Fórmula: C₂₁H₂₅N₅O₂ Peso molecular: 379.46

Moligand™ ? ≥98%

● En stock — Almacén en EE. UU., envío a la EU* Articulo #: M276039
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Nombre IUPAC

(2R,6S)-2,6-dimethyl-4-[6-[5-(1-methylcyclopropyl)oxy-1H-indazol-3-yl]pyrimidin-4-yl]morpholine

SMILES

CC1CN(CC(O1)C)C2=NC=NC(=C2)C3=NNC4=C3C=C(C=C4)OC5(CC5)C

InChIKey
ATUUNJCZCOMUKD-OKILXGFUSA-N

InChI

1S/C21H25N5O2/c1-13-10-26(11-14(2)27-13)19-9-18(22-12-23-19)20-16-8-15(28-21(3)6-7-21)4-5-17(16)24-25-20/h4-5,8-9,12-14H,6-7,10-11H2,1-3H3,(H,24,25)/tshow more

Sinónimos
(2R,6S)-2,6-Dimethyl-4-[6-[5-(1-methylcyclopropyl)oxy-1H-indazol-3-yl]pyrimidin-4-yl]morpholine | cis-2,6-Dimethyl-4-...
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Indazole
CAS: 271-44-3 Número EC: 205-978-4 Fórmula: C₇H₆N₂ Peso molecular: 118.14

≥99%

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Nombre IUPAC

1H-indazole

SMILES

C1=CC=C2C(=C1)C=NN2

InChIKey
BAXOFTOLAUCFNW-UHFFFAOYSA-N

InChI

1S/C7H6N2/c1-2-4-7-6(3-1)5-8-9-7/h1-5H,(H,8,9)

Sinónimos
1,2-Benzopyrazole | F0918-7060 | F1918-0009 | Indazole, 6 | UNII-7C4VQE5C03 | 1H-indazol | EINECS 205-978-4 | FT-0627...
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IKK-16 (hydrochloride)
CAS: 1186195-62-9 Fórmula: C₂₈H₂₉N₅OS • HCl Peso molecular: 520.09

≥98%

● En stock — Almacén en EE. UU., envío a la EU* Articulo #: I274699
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Nombre IUPAC

[4-[[4-(1-benzothiophen-2-yl)pyrimidin-2-yl]amino]phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone;hydrochloride

SMILES

C1CCN(C1)C2CCN(CC2)C(=O)C3=CC=C(C=C3)NC4=NC=CC(=N4)C5=CC6=CC=CC=C6S5.Cl

InChIKey
XFVDIVQCZWDBCW-UHFFFAOYSA-N

InChI

1S/C28H29N5OS.ClH/c34-27(33-17-12-23(13-18-33)32-15-3-4-16-32)20-7-9-22(10-8-20)30-28-29-14-11-24(31-28)26-19-21-5-1-2-6-25(21)35-26;/h1-2,5-11,14,19,show more

Sinónimos
N-(4-Pyrrolidin-1-yl-piperidin-1-yl)-[4-(4-benzo[b]thiophen-2-yl-pyrimidin-2-ylamino)phenyl]carboxamidehydrochloride
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IKK-16 (IKK Inhibitor VII)
CAS: 873225-46-8 Número EC: 809-503-7 Fórmula: C₂₈H₂₉N₅OS Peso molecular: 483.63

≥99%

● En stock — Almacén en EE. UU., envío a la EU* Articulo #: I129698
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Nombre IUPAC

[4-[[4-(1-benzothiophen-2-yl)pyrimidin-2-yl]amino]phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone

SMILES

C1CCN(C1)C2CCN(CC2)C(=O)C3=CC=C(C=C3)NC4=NC=CC(=N4)C5=CC6=CC=CC=C6S5

InChIKey
BWZJBXAPRCVCKQ-UHFFFAOYSA-N

InChI

1S/C28H29N5OS/c34-27(33-17-12-23(13-18-33)32-15-3-4-16-32)20-7-9-22(10-8-20)30-28-29-14-11-24(31-28)26-19-21-5-1-2-6-25(21)35-26/h1-2,5-11,14,19,23H,3show more

Sinónimos
(4-((4-(1-Benzothiophen-2-yl)pyrimidin-2-yl)amino)phenyl)(4-pyrrolidin-1-ylpiperidin-1-yl)methanone | 873225-46-8 (fr...
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GNE7915, Inhibitor of leucine rich repeat kinase 2;Inhibitor of TTK protein kinase
CAS: 1351761-44-8 Fórmula: C₁₉H₂₁F₄N₅O₃ Peso molecular: 443.4

Moligand™ ? ≥98%

● En stock — Almacén en EE. UU., envío a la EU* Articulo #: G275946
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Nombre IUPAC

[4-[[4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-2-fluoro-5-methoxyphenyl]-morpholin-4-ylmethanone

SMILES

CCNC1=NC(=NC=C1C(F)(F)F)NC2=C(C=C(C(=C2)F)C(=O)N3CCOCC3)OC

InChIKey
XCFLWTZSJYBCPF-UHFFFAOYSA-N

InChI

1S/C19H21F4N5O3/c1-3-24-16-12(19(21,22)23)10-25-18(27-16)26-14-9-13(20)11(8-15(14)30-2)17(29)28-4-6-31-7-5-28/h8-10H,3-7H2,1-2H3,(H2,24,25,26,27)

Sinónimos
[4-[[4-(Ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinyl-methanone | (4-(...
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GSK2578215A
CAS: 1285515-21-0 Fórmula: C₂₄H₁₈FN₃O₂ Peso molecular: 399.42

≥98%(HPLC)

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Nombre IUPAC

5-(2-fluoropyridin-4-yl)-2-phenylmethoxy-N-pyridin-3-ylbenzamide

SMILES

C1=CC=C(C=C1)COC2=C(C=C(C=C2)C3=CC(=NC=C3)F)C(=O)NC4=CN=CC=C4

InChIKey
WCIGMFCFPXZRMQ-UHFFFAOYSA-N

InChI

1S/C24H18FN3O2/c25-23-14-19(10-12-27-23)18-8-9-22(30-16-17-5-2-1-3-6-17)21(13-18)24(29)28-20-7-4-11-26-15-20/h1-15H,16H2,(H,28,29)

Sinónimos
5-(2-fluoropyridin-4-yl)-2-phenylmethoxy-N-pyridin-3-ylbenzamide | Benzamide, 5-(2-fluoro-4-pyridinyl)-2-(phenylmetho...
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JH-II-127
CAS: 1700693-08-8 Fórmula: C₁₉H₂₁ClN₆O₃ Peso molecular: 416.87

≥98%

● En stock — Almacén en EE. UU., envío a la EU* Articulo #: J275343
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Nombre IUPAC

[4-[[5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-morpholin-4-ylmethanone

SMILES

CNC1=NC(=NC2=C1C(=CN2)Cl)NC3=C(C=C(C=C3)C(=O)N4CCOCC4)OC

InChIKey
HUEKBQXFNHWTQQ-UHFFFAOYSA-N

InChI

1S/C19H21ClN6O3/c1-21-16-15-12(20)10-22-17(15)25-19(24-16)23-13-4-3-11(9-14(13)28-2)18(27)26-5-7-29-8-6-26/h3-4,9-10H,5-8H2,1-2H3,(H3,21,22,23,24,25)

Sinónimos
[4-[[5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-morpholin-4-ylmethanone | [4-[[...
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LRRK2-IN-1, Inhibitor of leucine rich repeat kinase 2
CAS: 1234480-84-2 Fórmula: C₃₁H₃₈N₈O₃ Peso molecular: 570.7

Moligand™ ? ≥98%

● En stock — Almacén en EE. UU., envío a la EU* Articulo #: L125224
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Nombre IUPAC

2-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]anilino]-5,11-dimethylpyrimido[4,5-b][1,4]benzodiazepin-6-one

SMILES

CN1CCN(CC1)C2CCN(CC2)C(=O)C3=CC(=C(C=C3)NC4=NC=C5C(=N4)N(C6=CC=CC=C6C(=O)N5C)C)OC

InChIKey
IWMCPJZTADUIFX-UHFFFAOYSA-N

InChI

1S/C31H38N8O3/c1-35-15-17-38(18-16-35)22-11-13-39(14-12-22)29(40)21-9-10-24(27(19-21)42-4)33-31-32-20-26-28(34-31)36(2)25-8-6-5-7-23(25)30(41)37(26)3/show more

Sinónimos
BRD-K01436366-001-01-6 | 2,6-Diamino-hexanoic acid; hydrochloride | BDBM50379529 | 2-((2-Methoxy-4-(4-(4-methylpipera...
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CZC 25146
CAS: 1191911-26-8 Número EC: 802-315-6 Fórmula: C₂₂H₂₅FN₆O₄S Peso molecular: 488.54

10mM in DMSO

● En stock — Almacén en EE. UU., envío a la EU* Articulo #: C420850
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Nombre IUPAC

N-[2-[[5-fluoro-2-(2-methoxy-4-morpholin-4-ylanilino)pyrimidin-4-yl]amino]phenyl]methanesulfonamide

SMILES

COC1=C(C=CC(=C1)N2CCOCC2)NC3=NC=C(C(=N3)NC4=CC=CC=C4NS(=O)(=O)C)F

InChIKey
XXHHOTZUJIXPJX-UHFFFAOYSA-N

InChI

1S/C22H25FN6O4S/c1-32-20-13-15(29-9-11-33-12-10-29)7-8-19(20)26-22-24-14-16(23)21(27-22)25-17-5-3-4-6-18(17)28-34(2,30)31/h3-8,13-14,28H,9-12H2,1-2H3,show more

Sinónimos
N-[2-[[5-Fluoro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]methanesulfonamide；CZC-25146；...
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CZC 25146
CAS: 1191911-26-8 Número EC: 802-315-6 Fórmula: C₂₂H₂₅FN₆O₄S Peso molecular: 488.54

≥98%(HPLC)

● En stock — Almacén en EE. UU., envío a la EU* Articulo #: C287537
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Nombre IUPAC

N-[2-[[5-fluoro-2-(2-methoxy-4-morpholin-4-ylanilino)pyrimidin-4-yl]amino]phenyl]methanesulfonamide

SMILES

COC1=C(C=CC(=C1)N2CCOCC2)NC3=NC=C(C(=N3)NC4=CC=CC=C4NS(=O)(=O)C)F

InChIKey
XXHHOTZUJIXPJX-UHFFFAOYSA-N

InChI

1S/C22H25FN6O4S/c1-32-20-13-15(29-9-11-33-12-10-29)7-8-19(20)26-22-24-14-16(23)21(27-22)25-17-5-3-4-6-18(17)28-34(2,30)31/h3-8,13-14,28H,9-12H2,1-2H3,show more

Sinónimos
N-[2-[[5-Fluoro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]methanesulfonamide | CZC-2514...
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CZC 54252 hydrochloride
CAS: 1784253-05-9 PubChem CID: 90488950 Fórmula: C₂₂H₂₆Cl₂N₆O₄S Peso molecular: 541.45

≥98%(HPLC)

● En stock — Almacén en EE. UU., envío a la EU* Articulo #: C288538
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Nombre IUPAC

N-[2-[[5-chloro-2-(2-methoxy-4-morpholin-4-ylanilino)pyrimidin-4-yl]amino]phenyl]methanesulfonamide;hydrochloride

SMILES

COC1=C(C=CC(=C1)N2CCOCC2)NC3=NC=C(C(=N3)NC4=CC=CC=C4NS(=O)(=O)C)Cl.Cl

InChIKey
KWCBHUPLQMUKAF-UHFFFAOYSA-N

InChI

1S/C22H25ClN6O4S.ClH/c1-32-20-13-15(29-9-11-33-12-10-29)7-8-19(20)26-22-24-14-16(23)21(27-22)25-17-5-3-4-6-18(17)28-34(2,30)31;/h3-8,13-14,28H,9-12H2,show more

Sinónimos
N-[2-[[5-Chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]methanesulfonamide hydrochlor...
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CZC-25146 hydrochloride
CAS: 1330003-04-7 PubChem CID: 72193880 Fórmula: C₂₂H₂₆ClFN₆O₄S Peso molecular: 525.00

≥98%

● En stock — Almacén en EE. UU., envío a la EU* Articulo #: C412508
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Nombre IUPAC

N-[2-[[5-fluoro-2-(2-methoxy-4-morpholin-4-ylanilino)pyrimidin-4-yl]amino]phenyl]methanesulfonamide;hydrochloride

SMILES

COC1=C(C=CC(=C1)N2CCOCC2)NC3=NC=C(C(=N3)NC4=CC=CC=C4NS(=O)(=O)C)F.Cl

InChIKey
SKYQTYQDKAOHLP-UHFFFAOYSA-N

InChI

1S/C22H25FN6O4S.ClH/c1-32-20-13-15(29-9-11-33-12-10-29)7-8-19(20)26-22-24-14-16(23)21(27-22)25-17-5-3-4-6-18(17)28-34(2,30)31;/h3-8,13-14,28H,9-12H2,1show more

Sinónimos
CZC-25146(hydrochloride) | 1330003-04-7 | N-[2-[[5-fluoro-2-(2-methoxy-4-morpholin-4-ylanilino)pyrimidin-4-yl]amino]p...

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Preguntas frecuentes

Which compounds are listed for LRRK2?

Compounds associated with LRRK2 are grouped here under the Autophagy classification, with mechanism, structure, and reported potency shown per entry. Use it as a starting shortlist rather than a final selection.

How does LRRK2 sit within Autophagy?

LRRK2 is one target listing within the Autophagy classification. Compounds here may also appear under related targets, so check the selectivity data rather than assuming the annotation is exclusive.

What data should I check before ordering a compound from LRRK2?

For compounds listed under LRRK2, check purity — typically 98% or better by HPLC — the reported potency and the assay it was measured in, solubility and recommended stock solvent, and storage and stability. Batch-specific values are given on the Certificate of Analysis. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.

How do I find related targets or backup compounds for LRRK2?

Browse the parent Autophagy listing to reach targets neighbouring LRRK2, and use the structure search to find analogs of a compound that worked. Unlisted compounds and bulk quantities: [email protected]. We supply verified businesses, research institutions, universities, and government agencies.