Nutlin-3a [(-)-Nutlin] is a more potent diasteromer of nutlin-3, a racemic MDM2 antagonist. It is called enantiomer A because it will serve as the first peak elution of racemic Nutlin-3 chiral purification. Nutlin-3a is a potent inhibitor of MDM2 (murine
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Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This compound belongs to the class of organic compounds known as stilbenes. These are organic compounds containing a 1,2-diphenylethylene moiety. Stilbenes (C6-C2-C6 ) are derived from the common phenylpropene (C6-C3) skeleton building block. The introduction of one or more hydroxyl groups to a phenyl ring lead to stilbenoids.
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1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
1.Yun Chen, Yang Wang, Shuai Shen, Libin Zhang, Jun Liu, Xiangyun Yan, Hao Peng, Zheyuan Xu. (2025) RHBDD1 induces cell cycle arrest in TP53-mutant NSCLC cells by promoting endoplasmic reticulum-associated degradation of p53 and DNA-PKcs. EUROPEAN JOURNAL OF MEDICAL RESEARCH, [PMID:41013641][10.1186/s40001-025-03116-y]
2.Jiajian Wang, Lanqing Zhang, Runfang Li, Rui Yang, Fan Yang, Fei Yu, Jihong Zhang. (2025) Gambogic acid restores wild-type-like p53 functions to induce ferroptosis in mutant p53 cancer cells. BIOCHEMICAL PHARMACOLOGY, [PMID:41213406][10.1016/j.bcp.2025.117533]
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