PAPA NONOate - ≥97% , CAS No.146672-58-4

CAS: 146672-58-4 Cat. No.: P275960 Molecular Weight: 176.22 EC Number: 633-929-0

GRADE & PURITY ≥97%

Synonyms

N-[3-aminopropyl(propyl)amino]-N-hydroxynitrous amide | PAPA NONOate | NOC-15 | NSC634220 | 1-Propanamine, 3-(2-hydroxy-2-nitroso-1-propylhydrazinyl)- | PAPA/NO | (Z)-[3-aminopropyl(propyl)amino]-hydroxyimino-oxidoazanium | (Z)-1-[N-(3-aminopropyl)-N-(n-p

Storage

Protected from light,Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Overview

PAPA NONOate is a NO donor with a NO release half-life of 77 min (22-25°C). PAPA NONOate may represent a potential research for impaired wound healing in diabetes by increasing the rate of collagen synthesis at the wound site.

Specifications

Synonyms

N-[3-aminopropyl(propyl)amino]-N-hydroxynitrous amide | PAPA NONOate | NOC-15 | NSC634220 | 1-Propanamine, 3-(2-hydroxy-2-nitroso-1-propylhydrazinyl)- | PAPA/NO | (Z)-[3-aminopropyl(propyl)amino]-hydroxyimino-oxidoazanium | (Z)-1-[N-(3-aminopropyl)-N-(n-p

Specifications & Purity

≥97%

Biochemical and Physiological Mechanisms

Nitric oxide (NO) donor. Has an NO release half life of 77 minutes. Regulates caspase-3 activity and suppresses caspase-mediated apoptosis. Shows anti-ischemic effects in vivo.s

Storage

Protected from light, Store at -20°C, Desiccated

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥97%

Names and Identifiers

• Canonical Smiles: CCCN(CCCN)[N+](=NO)[O-]
• IUPAC Name: (Z)-[3-aminopropyl(propyl)amino]-hydroxyimino-oxidoazanium
• InChIKey: QODRTFHTYGHQMT-NTMALXAHSA-N
• INCHI: 1S/C6H16N4O2/c1-2-5-9(6-3-4-7)10(12)8-11/h11H,2-7H2,1H3/b10-8-
• Isomeric SMILES: CCCN(CCCN)/[N+](=N/O)/[O-]
• Molecular Weight: 176.22
• Reaxy-Rn: 10066144
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=10066144&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic nitrogen compounds
    • Class Organonitrogen compounds
      • Subclass Amines
        • Level5 Primary amines
          • Level6 Monoalkylamines

• Kingdom: Organic compounds
• Superclass: Organic nitrogen compounds
• Class: Organonitrogen compounds
• Subclass: Amines
• Intermediate Tree Nodes: Primary amines
• Direct Parent: Monoalkylamines
• Alternative Parents: Organopnictogen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Primary aliphatic amine - Aliphatic acyclic compound
• Description: This compound belongs to the class of organic compounds known as monoalkylamines. These are organic compounds containing an primary aliphatic amine group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: Soluble in water to 100 mM
• Sensitivity: light & Moisture sensitive
• Molecular Weight: 176.220 g/mol
• XLogP3: 0.800
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 6
• Exact Mass: 176.127 Da
• Monoisotopic Mass: 176.127 Da
• Topological Polar Surface Area: 90.600 Ų
• Heavy Atom Count: 12
• Formal Charge: 0
• Complexity: 140.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 1
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 1
• Covalently-Bonded Unit Count: 1