Xanthine - UltraBio™, ≥99% , CAS No.69-89-6

CAS: 69-89-6 Cat. No.: X755591 Molecular Weight: 152.11 Beilstein Registry Number: 8733 EC Number: 200-718-6 PubChem CID: 1188

GRADE & PURITY UltraBio™, ≥99%

Storage

Store at 2-8°C,Protected from light

Shipped In

Wet ice

Overview

Xanthine is a purine that can be produced in the purine metabolic pathway via different precursors:

• Guanine deamination by guanine deaminase
• Hypoxanthine conversion by xanthine oxidoreductase

Xanthine or its derivatives are naturally present in animal organs, yeast, potatoes, coffee beans, and tea.

Application:

Xanthine has been used as a substrate for the determination of xanthine oxidase (XOD) inhibitory activity. It has also been used in the following systems:

• yeast culture
• human cell line culture
• recombinant viruses cloned as bacterial artificial chromosomes in Escherichia coli

Specifications

Specifications & Purity

UltraBio™, ≥99%

Biochemical and Physiological Mechanisms

Xanthine and xanthine oxidase are used to generate superoxide radicals to measure the activity of superoxide dismutase.

Storage

Store at 2-8°C, Protected from light

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

UltraBio™

Purity

≥99%

Names and Identifiers

• Canonical Smiles: C1=NC2=C(N1)C(=O)NC(=O)N2
• IUPAC Name: 3,7-dihydropurine-2,6-dione
• InChIKey: LRFVTYWOQMYALW-UHFFFAOYSA-N
• INCHI: 1S/C5H4N4O2/c10-4-2-3(7-1-6-2)8-5(11)9-4/h1H,(H3,6,7,8,9,10,11)
• Isomeric SMILES: C1=NC2=C(N1)C(=O)NC(=O)N2
• WGK Germany: 3
• RTECS: ZD7700000
• PubChem CID: 1188
• Molecular Weight: 152.11
• Beilstein: 8733
• Reaxy-Rn: 609330

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Class Imidazopyrimidines
      • Subclass Purines and purine derivatives

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Class: Imidazopyrimidines
• Subclass: Purines and purine derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Xanthines
• Alternative Parents: 6-oxopurines Alkaloids and derivatives Pyrimidones Vinylogous amides Imidazoles Heteroaromatic compounds Ureas Lactams Azacyclic compounds Organopnictogen compounds Organooxygen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Xanthine - 6-oxopurine - Purinone - Alkaloid or derivatives - Pyrimidone - Pyrimidine - Azole - Imidazole - Heteroaromatic compound - Vinylogous amide - Lactam - Urea - Azacycle - Hydrocarbon derivative - Organic oxide - Organooxygen compound - Organonitrogen compound - Organic nitrogen compound - Organopnictogen compound - Organic oxygen compound - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as xanthines. These are purine derivatives with a ketone group conjugated at carbons 2 and 6 of the purine moiety.
• External Descriptors: a small molecule

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: 1 M NaOH: 0.1 M, clear, colorless to light yellow
• Sensitivity: light sensitive
• Molecular Weight: 152.110 g/mol
• XLogP3: -0.700
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 152.033 Da
• Monoisotopic Mass: 152.033 Da
• Topological Polar Surface Area: 86.900 Ų
• Heavy Atom Count: 11
• Formal Charge: 0
• Complexity: 217.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

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59. Tingting Han, Yang Huang, Chong Sun, Daoying Wang, Weimin Xu.  (2021)  A Water-Dispersible Carboxylated Carbon Nitride Nanoparticles-Based Electrochemical Platform for Direct Reporting of Hydroxyl Radical in Meat.  Foods,  11  (1): (40).  [PMID:35010165] [10.3390/foods11010040]

60. Huiwang Dai, Wenjun Zhou, Wei Wang, Zhiqi Liu.  (2021)  Unveiling the role of cobalt species in the Co/N-C catalysts-induced peroxymonosulfate activation process.  JOURNAL OF HAZARDOUS MATERIALS,      [PMID:34836695] [10.1016/j.jhazmat.2021.127784]

61. Huiyi Yang, Qiyi He, Junkang Pan, Mingxia Lin, Zhiting Lao, Qinglan Li, Xiping Cui, Suqing Zhao.  (2021)  PtCu nanocages with superior tetra-enzyme mimics for colorimetric sensing and fluorescent sensing dehydroepiandrosterone.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2021.130905]

62. Yan Liu, Chenggang Han, Tao Lu, Yi Liu, Hao Chen, Can Yang, Yanbei Tu, Yanfang Li.  (2021)  Investigation of the interaction between Chrysoeriol and xanthine oxidase using computational and in vitro approaches.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:34506859] [10.1016/j.ijbiomac.2021.08.231]

63. Chao Fan, Bei Liu, Hui Li, Kaijun Quan, Jia Chen, Hongdeng Qiu.  (2021)  N-Vinyl pyrrolidone and undecylenic acid copolymerized on silica surface as mixed-mode stationary phases for reversed-phase and hydrophilic interaction chromatography.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:34509123] [10.1016/j.chroma.2021.462534]

64. Mingqi Xu, Dingzhou Liu, Jinghua Yang, Qian Zhu, Yunliang Wang, Jingquan Sha.  (2021)  MIL-100(Fe) Metal–Organic Framework Nanospheres Embedded in Graphene Matrixes for Xanthine Fluorescence Sensing.  ACS Applied Nano Materials,      [PMID:] [10.1021/acsanm.1c01145]

65. Yin Wan, Jin Qian, Yizhen Li, Yuefeng Shen, Yanru Chen, Guiming Fu, Mingyong Xie.  (2021)  Inhibitory mechanism of xanthine oxidase activity by caffeoylquinic acids in vitro.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:34146563] [10.1016/j.ijbiomac.2021.06.075]

66. Xiaona Dong, Xiaoxue Yang, Sheng Hua, Ziqian Wang, Tianming Cai, Canlan Jiang.  (2021)  Unraveling the mechanisms for persulfate-based remediation of triphenyl phosphate-contaminated soils: Complicated soil constituent effects on the formation and propagation of reactive oxygen species.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2021.130662]

67. Huilong Xiang, Huan Lei, Ziyuan Liu, Yongjie Liu, Yang Li, Yinsheng Qiu, Lingyun Xu.  (2021)  Network pharmacology and molecular docking analysis on molecular targets: Mechanisms of baicalin and baicalein against hyperuricemic nephropathy.  TOXICOLOGY AND APPLIED PHARMACOLOGY,      [PMID:34044073] [10.1016/j.taap.2021.115594]

68. Yintao Li, Zisheng Luo, Gangfeng Li, Tarun Belwal, Li Li, Yanqun Xu, Bin Su, Xingyu Lin.  (2021)  Interference-free Detection of Caffeine in Complex Matrices Using a Nanochannel Electrode Modified with Binary Hydrophilic–Hydrophobic PDMS.  ACS Sensors,      [PMID:33752324] [10.1021/acssensors.1c00004]

69. Lu Kang, Ju Liu, Hongyang Zhang, Min Jiang, Yidian Jin, Min Zhang, Ping Hu.  (2020)  Improved ultra-high performance liquid chromatographic method for simultaneous determination of five gout-related metabolites in human serum.  JOURNAL OF SEPARATION SCIENCE,  44  (5): (954-962).  [PMID:33348445] [10.1002/jssc.202000974]

70. Wang Xiaotao, Xu Junyang, Xie Xun, Li Xuefeng, Liu Zuifang.  (2020)  Poly(vinyldiaminotriazine) nanoparticle adsorption of small drug molecules in aqueous phase and the role of synergistic interaction between hydrogen bonding and hydrophobic affinity.  COLLOID AND POLYMER SCIENCE,  299  (1): (37-47).  [PMID:] [10.1007/s00396-020-04765-7]

71. Cui Ying, Li Junhua, Liu Mengqin, Tong Haixia, Liu Zeng, Hu Jiawen, Qian Dong.  (2020)  Convenient synthesis of three-dimensional hierarchical CuS@Pd core-shell cauliflowers decorated on nitrogen-doped reduced graphene oxide for non-enzymatic electrochemical sensing of xanthine.  MICROCHIMICA ACTA,  187  (11): (1-11).  [PMID:33033940] [10.1007/s00604-020-04570-7]

72. Tingting Li, Likun Ren, Dangfeng Wang, Minjie Song, Qiuying Li, Jianrong Li.  (2020)  Effect of allicin and its mechanism of action in purine removal in turbot.  JOURNAL OF FOOD SCIENCE,  85  (10): (3562-3569).  [PMID:32856309] [10.1111/1750-3841.15394]

73. Di Zhu, Huiyuan Ma, Qingfang Zhen, Jianjiao Xin, Lichao Tan, Chunjing Zhang, Xinming Wang, Boxin Xiao.  (2020)  Hierarchical flower-like zinc oxide nanosheets in-situ growth on three-dimensional ferrocene-functionalized graphene framework for sensitive determination of epinephrine and its oxidation derivative.  APPLIED SURFACE SCIENCE,      [PMID:] [10.1016/j.apsusc.2020.146721]

74. Yongjie Liu, Hao Chen, Huilong Xiang, Huan Lei, Di Zhang, Yinsheng Qiu, Lingyun Xu.  (2020)  Inhibition and molecular mechanism of diosmetin against xanthine oxidase by multiple spectroscopies and molecular docking.  NEW JOURNAL OF CHEMISTRY,  44  (17): (6799-6809).  [PMID:] [10.1039/D0NJ00679C]

75. Xiaoying Guo, Xinyu Wang, Dongwei Huang, Jinjie Zhang, Dalun Xu, Wenge Yang, Qijie Hu, Zhongxiang Fang, Tao Huang.  (2020)  Method study on determination of total purine content in fish meat by diazotization reaction combined with SERS.  LWT-FOOD SCIENCE AND TECHNOLOGY,      [PMID:] [10.1016/j.lwt.2020.109027]

76. Meng Tian, Zhenhua Li, Ruihong Song, Yingxian Li, Chengang Guo, Yujie Sha, Wanling Cui, Shicai Xu, Guodong Hu, Jihua Wang.  (2019)  Graphene biosensor as affinity biosensors for biorecognition between Guanine riboswitch and ligand.  APPLIED SURFACE SCIENCE,      [PMID:] [10.1016/j.apsusc.2019.144303]

77. Yuan Yuan, Min Jiang, Hongyang Zhang, Ju Liu, Min Zhang, Ping Hu.  (2019)  Simultaneous quantification of urinary purines and creatinine by ultra high performance liquid chromatography with ultraviolet spectroscopy and quadrupole time-of-flight mass spectrometry: Method development, validation, and application to gout study.  JOURNAL OF SEPARATION SCIENCE,  42  (15): (2523-2533).  [PMID:31144454] [10.1002/jssc.201900170]

78. Qiuyue Sha, Bingyang Sun, Chen Yi, Ruixue Guan, Jian Fei, Zhaoyu Hu, Bifeng Liu, Xin Liu.  (2019)  A fluorescence turn-on biosensor based on transferrin encapsulated gold nanoclusters for 5-hydroxytryptamine detection.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2019.05.060]

79. Di Zhu, Dongxuan Guo, Lulu Zhang, Lichao Tan, Haijun Pang, Huiyuan Ma, Mo Zhai.  (2018)  Non-enzymatic xanthine sensor of heteropolyacids doped ferrocene and reduced graphene oxide via one-step electrodeposition combined with layer-by-layer self-assembly technology.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2018.10.151]

80. Donglai Qi, Qian Li, Chen Chen, Xiang Wang.  (2018)  Ferulic acid modification enhances the anti-oxidation activity of natural Hb in vitro.  Artificial Cells Nanomedicine and Biotechnology,      [PMID:29533098] [10.1080/21691401.2018.1448987]

81. Danling Liang, Tianqiao Yong, Shaodan Chen, Yizhen Xie, Diling Chen, Xinxin Zhou, Dan Li, Muxia Li, Lu Su, Dan Zuo.  (2018)  Hypouricemic Effect of 2,5-Dihydroxyacetophenone, a Computational Screened Bioactive Compound from Ganoderma applanatum, on Hyperuricemic Mice.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  19  (5): (1394).  [PMID:29735945] [10.3390/ijms19051394]

82. Yizhen Li, Yin Wan, Ruyi Li, Laojiu Xu, Mingyong Xie, Guiming Fu.  (2018)  Solvent extraction of caffeoylquinic acids from Artemisia selengensis Turcz leaves and their in vitro inhibitory activities on xanthine oxidase.  INDUSTRIAL CROPS AND PRODUCTS,      [PMID:] [10.1016/j.indcrop.2018.03.055]

83. Di Zhu, Huiyuan Ma, Haijun Pang, Lichao Tan, Jia Jiao, Tao Chen.  (2018)  Facile fabrication of a non-enzymatic nanocomposite of heteropolyacids and CeO2@Pt alloy nanoparticles doped reduced graphene oxide and its application towards the simultaneous determination of xanthine and uric acid.  ELECTROCHIMICA ACTA,      [PMID:] [10.1016/j.electacta.2018.01.185]

84. Xiaoju Wu, Tongming Chen, Jianxing Wang, Guowei Yang.  (2017)  Few-layered MoSe2 nanosheets as an efficient peroxidase nanozyme for highly sensitive colorimetric detection of H2O2 and xanthine.  Journal of Materials Chemistry B,  6  (1): (105-111).  [PMID:32254198] [10.1039/C7TB02434G]

85. Jing Wang, Dongfang Shi, Meizhu Zheng, Bing Ma, Jing Cui, Chunming Liu, Chengyu Liu.  (2017)  Screening, separation, and evaluation of xanthine oxidase inhibitors from Paeonia lactiflora using chromatography combined with a multi-mode microplate reader.  JOURNAL OF SEPARATION SCIENCE,  40  (21): (4160-4167).  [PMID:28857450] [10.1002/jssc.201700690]

86. Lu-Liang Wang, Cheng-Xiong Yang, Xiu-Ping Yan.  (2017)  In Situ Growth of Covalent Organic Framework Shells on Silica Microspheres for Application in Liquid Chromatography.  ChemPlusChem,  82  (6): (933-938).  [PMID:31961565] [10.1002/cplu.201700223]

87. Zeynep Tohtahon, Lu Zhang, Jianxin Han, Xing Xie, Zongcai Tu, Tao Yuan.  (2017)  Extraction optimization, structural characterization and bioactivity evaluation of triterpenoids from hawthorn (Crataegus cuneata) fruits.  JOURNAL OF FOOD BIOCHEMISTRY,  41  (4): (e12377).  [PMID:] [10.1111/jfbc.12377]

88. Malin Cui, Jingdan Zhou, Yuan Zhao, Qijun Song.  (2016)  Facile synthesis of iridium nanoparticles with superior peroxidase-like activity for colorimetric determination of H2O2 and xanthine.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2016.11.145]

89. Yin Wan, Bin Zou, Hailong Zeng, Lunning Zhang, Ming Chen, Guiming Fu.  (2016)  Inhibitory effect of verbascoside on xanthine oxidase activity.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:27616694] [10.1016/j.ijbiomac.2016.09.022]

90. Yating Xu, Ju Liu, Hongyang Zhang, Min Jiang, Lingling Cao, Min Zhang, Wei Sun, Shengli Ruan, Ping Hu.  (2016)  Hypercrosslinked strong cation-exchange polymers for selective extraction of serum purine metabolites associated with gout.  TALANTA,      [PMID:26946024] [10.1016/j.talanta.2016.01.014]

91. Fengmin Qiao, Jiaomei Wang, Shiyun Ai, Lifang Li.  (2015)  As a new peroxidase mimetics: The synthesis of selenium doped graphitic carbon nitride nanosheets and applications on colorimetric detection of H2O2 and xanthine.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2015.04.074]

92. Liao Yin-Han, Liao Hai-Qing, Wu Xing-Mou, Liang Xu-Zhi, Zhang Shi-Yu, Liu Yan, Mo Wei-Jiu, Li Sui-Hua, Jiang Ming-Yang, Gao Zhi-Wei, Wang Jia-Xi, Gao Ming, Li Hao, Li Cui-Ping.  (2025)  Infectious microenvironment responsive bimetallic sulfide combined with NIR irradiation to enhance photodynamic gas synergistic therapy of maxillofacial trauma.  RARE METALS,      [PMID:] [10.1007/s12598-025-03409-5]

93. Zhao Kaiyue, Xiang Ningyao, Wang Yu-Qi, Ye Jinyu, Jin Zihan, Fu Linke, Chang Xiaoxia, Wang Dong, Xiao Hai, Xu Bingjun.  (2025)  A molecular design strategy to enhance hydrogen evolution on platinum electrocatalysts.  Nature Energy,      [PMID:] [10.1038/s41560-025-01754-4]

94. Zhenkun Mao, Changjun Hu, Zhentao Li, Zilin Chen.  (2019)  A reversed-phase/hydrophilic bifunctional interaction mixed-mode monolithic column with biphenyl and quaternary ammonium stationary phases for capillary electrochromatography.  ANALYST,  144  (14): (4386-4394).  [PMID:31210197] [10.1039/C9AN00428A]

95. Yuhuan Wang, Ruyan Wang, Lei Wang, Licheng Wang, Yong Guo, Xiaojing Liang, Shuai Wang.  (2019)  Nanogold hybrid silica gel and its 1-octadecanethiol self-assembled modified composite as a stationary phase for liquid chromatography.  ANALYST,  144  (9): (3072-3079).  [PMID:30916685] [10.1039/C9AN00270G]

96. Hui Yang, Huimin Qiu, Jie Shan, Chao Nie, Yechun Lin, Yizhong Shen, Xianwen Wang.  (2025)  Waste tobacco leaf-driven carbon dot nanozymes with high reactive oxygen species scavenging and anti-inflammatory activities for the amelioration of acute lung injury.  INDUSTRIAL CROPS AND PRODUCTS,      [PMID:] [10.1016/j.indcrop.2025.120958]

97. Wu Chenxi, Zhang Na, Li Hailin, Wang Hao, Han Lifeng, Wang Yuefei, Li Fuyi, Tian Fei.  (2025)  Preparation of immobilized xanthine oxidase with magnetic metal–organic framework and its application in screening of active ingredients in traditional Chinese medicine.  MICROCHIMICA ACTA,  192  (5): (1-12).  [PMID:40272571] [10.1007/s00604-025-07167-0]

98. Jiemei Liang, Hua Zhu, Qiyuan Yang, Zhouwei Li, Xiang Meng, Lanlan Fan, Li Li.  (2025)  Exploring the Material Basis of Taxillus chinensis in the Treatment of Hyperuricemia Nephropathy Through Absorbed Into Blood Component Analysis and Network Pharmacology.  BIOMEDICAL CHROMATOGRAPHY,  39  (5): (e70066).  [PMID:40214159] [10.1002/bmc.70066]

99. Yuting Jian, Xiaoqun Zhong, Junjing Wang, Feijie Wang, Shaokun Yu, Jiannan Guo, Xiaona Gan, Juntao Kan, Wei Guo.  (2025)  Nutraceutical potential of a novel phytonutrients formula in managing hyperuricemia: In silico, in vitro, and in vivo investigations.  Journal of Functional Foods,      [PMID:] [10.1016/j.jff.2025.106849]

100. Shiquan Zheng, Jiale Ke, Hanren Chen, Huaze Shao, Fengxin Zheng, Runhui Zhang, Zean Zhao, Jianxin Pang, Lihong Liu.  (2025)  A novel method for screening antihyperuricemic drugs by combining aptamer sensor array, exonuclease III-DNA walker and linear discriminant analysis.  Journal of Pharmaceutical Analysis,      [PMID:41631245] [10.1016/j.jpha.2025.101345]

101. Zixi Li, Meng Dong, Libo Qi, Shan Shang, Yan Guo, Lei Qin, Baoshang Fu.  (2025)  Mass spectrometry-based lipidomics combined with flavoromics reveal the mechanism of characteristic flavor formation in Chelidonichthys kumu bone soup treated with different edible oils by frying.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2025.106724]

102. Yuan Luo, Jinyan Xie, Hao Yang, Yu Huang, Xinbin Yang.  (2025)  Xanthine oxidase inhibitory and anti-hyperuricemic properties of sulfonate derivatives of naringenin.  BIOORGANIC CHEMISTRY,      [PMID:40441027] [10.1016/j.bioorg.2025.108618]

103. Zhenlong He, Yanli Yang, Ruijiao Li, Qian He.  (2025)  Enhanced multi-enzyme activity and bone-targeted phosphorus-doped carbon dots for precise antioxidant therapy of rheumatoid arthritis.  CARBON,      [PMID:] [10.1016/j.carbon.2025.120514]

104. Xiaoyu Shen, Yejian Mo, Jian Ren, Kexin Liu, Chunlin Deng.  (2025)  Inhibition of xanthine oxidase by copper-gallate coordination polymers and its mechanistic study.  JOURNAL OF MOLECULAR STRUCTURE,      [PMID:] [10.1016/j.molstruc.2025.142912]

105. Xinjian Bi, Ruibo Huang, Tingmin Qu, Ying Wu, Hao Wu, Daichen Mu, Jian Hu, Juan Liao, Yanting Duan, Li Wen.  (2025)  Screening and Identification of Multitarget Uric Acid-Lowering Peptides Derived from Rice Residue Protein and Analysis of Their Mechanisms.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:40553021] [10.1021/acs.jafc.5c01770]

106. Zhouyu Yu, Lijia Zou, Ruiqi Liu, Xiaoyan Zhang, Zhen Cheng, Si Chen, Baisong Chang.  (2025)  Leveraging Activatable Janus Nanoprobes for NIR-II Imaging and Enzyme-Like Activity in Monitoring Liver Fibrosis.  Advanced Therapeutics,      [PMID:] [10.1002/adtp.202500142]

107. Hong Wang, Yu Wang, Yan Li, Wenli Zhao, Jinqian Pang, Wenjuan Liang.  (2025)  Accumulation of flavor precursors and markers belonging to different primary processing Coffea arabica beans.  FOOD CHEMISTRY,      [PMID:41061617] [10.1016/j.foodchem.2025.146610]

108. Yan Huang, Cuixia Weng, Fajian Zeng, Xiaoxiao Dai, Xiaoying Qiu, Jiachi Lin, Botao Peng, Xiaonan Zhang, Zhiwei Liu.  (2025)  Ultrasound-driven antisolvent precipitation for engineered naringenin ultrafine crystals with potent xanthine oxidase inhibitory and bacteriostatic effects.  ULTRASONICS SONOCHEMISTRY,      [PMID:41176947] [10.1016/j.ultsonch.2025.107630]

109. Mingxia Zhou, Linping Lu, Xinyu Xu, Yefan Zhou, Huan Fang, Xue Wang, Dongxu Li, Xiaoyan Li, Jiaqi Hua, Jiahe Liu, Yingxia Li, Libin Jiang, Qiuju Miao, Hongtao Wen, Jing He, Shenyu Yang.  (2025)  EUK nanozyme-loaded PL&GA coacervate droplets attenuate ulcerative colitis through restoring gut homeostasis and restricting intestinal cell ferroptosis.  Materials Today Bio,      [PMID:41215769] [10.1016/j.mtbio.2025.102466]

110. Shen Jiayi, Luo Yuwen, Hu Wuming, Zhang Susu, Yang Yu, Lan Linwen, Liu Enqian, Xu Jian, Hu Tingting, Nie Jingjun, Chen Dafu, Liang Ruizheng, Lyu Lingchun.  (2025)  Dual-function MgSrCeAl-LDH nanosheets enable both ROS clearance and enhanced angiogenesis for myocardial ischemia/reperfusion injury therapy.  JOURNAL OF NANOBIOTECHNOLOGY,  23  (1): (1-20).  [PMID:41139778] [10.1186/s12951-025-03673-8]

111. Kaiyu Wang, Minghao Liu, Yan Zhang, Wannan Li, Weiwei Han.  (2025)  Artificial Intelligence-Aided Virtual Screening and Molecular Dynamics Analysis of Novel Xanthine Oxidase Inhibitory Peptides Derived from Sunflower (Helianthus annuus) Proteins.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:41187988] [10.1021/acs.jafc.5c05340]

112. Ping Gao, Qiang Zhang, Jing Sun, Zhongmin Su, Qi Chang, Leijiao Li, Wenliang Li.  (2025)  Flexible multi-enzyme biosensor based on MOF-74/Argdot biomimetic mineralization for dynamic multi-analyte monitoring in sweat.  BIOELECTROCHEMISTRY,      [PMID:41223598] [10.1016/j.bioelechem.2025.109144]

113. Ruxi Lin, Rui Tan, Tao Yang, Qun Zhou, Juan Mu, Yan Zhao, Guoqi Zhang, Xiaojun Luo.  (2025)  Dual-mode SERS/colorimetric sensing of xanthine in fish and shrimp based on peroxidase like activity multifunctional CoS@au nanoflower.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2025.116520]

114. Haonan Zhang, Huili Zhao, Yingying Liu, Tuo Ji, Yuzhi Gao, Guohua Chen, Yuwei Bian, Zhiwen Zhao, Kun Yu, Xinwei Li, Xuzhu Gao.  (2025)  A multifunctional MOF-818-based nanozyme for synergistic therapy of hepatic steatosis via dual-channel lipid regulation and ROS scavenging.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2025.171909]

115. Jinqian Pang, Wenli Zhao, Yu Wang, Yan Li, Hong Wang, Weimin Zhang, Wenjuan Liang.  (2025)  Accumulation and transformation of C6, C9 and C12 phenols from the peel, leaves and branches of Nephelium lappaceum L..  FOOD RESEARCH INTERNATIONAL,      [PMID:41508532] [10.1016/j.foodres.2025.118177]

116. Kanru Fu, Zhengri Cong, Xinghao Wang, Haocheng Sun, Yong Zhang.  (2025)  Hydrangea-like NiTi layered double hydroxide-derived balsawood@Ti3C2Tx-based disposable electrode for convenient residue analysis of carbendazim pesticide.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2025.172190]

117. Hong Wang, Yan Li, Wenli Zhao, Yu Wang, Jinqian Pang, Li Wan, Qipeng Zhang, Wenjuan Liang.  (2025)  Effects of adding L-cysteine on the accumulation of the main compounds and their new analogs in roasting Coffea arabica beans.  FOOD CHEMISTRY,      [PMID:41478069] [10.1016/j.foodchem.2025.147686]

118. Hongyu Chen, Jiayi Guo, Xinrui Sun, Peipei Tian, Wenping Zhu, Manman Sun, Zengchen Liu, Qingfeng Li, Yahong Chen.  (2026)  Analyte-guided precise regulation of gold nanoflower etching mechanism for enhanced dopamine selectivity via bisphenol-triggered Schiff base/Michael addition and intramolecular hydrogen bond synergy.  TALANTA,      [PMID:41558403] [10.1016/j.talanta.2026.129412]

119. Yue Zhang, Xi Liu, Li Hu, Tengyun Zuo, Kun Xia, Hao Wang, Huaming Yang.  (2026)  Inorganic–Organic Interfacial Engineering of Earth-Abundant Phytoliths for Multifunctional Hemostat.  ACS Applied Bio Materials,      [PMID:41563372] [10.1021/acsabm.5c02277]

120. Hong Wang, Li Wan, Yu Wang, Yan Li, Wenli Zhao, Wenjuan Liang.  (2026)  Main characteristic metabolites with xanthine oxidase inhibitory activities from Yunnan Coffea arabica husks.  Food Chemistry-X,      [PMID:41704874] [10.1016/j.fochx.2026.103637]

121. Yang Lingfan, Liu Ruiqi, Shi Yingkun, Li Changhao, Wang Guangxian, Xie Haijiao, Luo Ruiming, Wang Songlei.  (2026)  DFT-guided Cu–MoS2/g-C3N4 Heterostructure Electrochemical Sensor for Broad-range, Non-enzymatic Detection of Xanthine and Hypoxanthine in Meat.  Food and Bioprocess Technology,  19  (3): (152).  [PMID:] [10.1007/s11947-026-04252-x]

122. Xiqian Tan, Shuaibo Gao, Xiaoxiao Cheng, Lijun You, Xuepeng Li, Jianrong Li.  (2026)  Biological Characteristics of a Probiotic Wickerhamomyces anomalus Isolated from Pickled Vegetables and Its Function in Preventing Hyperuricemia in Mice.  Foods,  15  (4): (744).  [PMID:41750936] [10.3390/foods15040744]

123. Xi Zheng, Yanpei Huang, Weijun Chen, Wenxue Chen, Qiuping Zhong, Jianfei Pei, Ying Lv, Rongrong He, Haiming Chen, Ming Zhang, Ruimin Wang.  (2026)  Biological activities, metabolic profiles, and in vitro uric acid-lowering mechanisms of cell-free supernatant from coconut water by Limosilactobacillus DO28L8.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2026.108767]