Sodium deoxycholate - 10mM in DMSO , CAS No.302-95-4

CAS: 302-95-4 Cat. No.: S423127 Molecular Weight: 414.56 Beilstein Registry Number: 3581950 EC Number: 206-132-7 PubChem CID: 23668196

GRADE & PURITY 10mM in DMSO

Synonyms

Kybella | sodium (3alpha,5beta,12alpha)-3,12-dihydroxycholan-24-oate | Deoxycholic acid sodium salt | HY-N0593A | Na-Desoxycholat | ISOQUINOLINIUM, 2,2'-(1,5-PENTANEDIYLBIS(OXY(3-OXO-3,1-PROPANEDIYL)))BIS(1-((3,4-DIMETHOXYPHENYL)METHYL)-1,2,3,4-TETRAHYDRO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Sodium deoxycholate is an ionic detergent for the solubilization of membrane-bound proteins. Deoxycholic Acid, Sodium Salt is reported to induce tyrosine phosphorylation of b-catenin and its subsequent translocation to the nucleus, promoting activation of β-catenin signaling (effective concentration 5-50 μM). Sodium deoxycholate is a bile salt and an ionic detergent. Bile salts work along with lipids/fats/cholesterol and form mixed micelles in the intestine. These micelles help in fat digestion and absorption through the intestinal wall
An ionic detergent for the solubilization of membrane-bound proteins.

Specifications

Synonyms

Kybella | sodium (3alpha, 5beta, 12alpha)-3, 12-dihydroxycholan-24-oate | Deoxycholic acid sodium salt | HY-N0593A | Na-Desoxycholat | ISOQUINOLINIUM, 2, 2'-(1, 5-PENTANEDIYLBIS(OXY(3-OXO-3, 1-PROPANEDIYL)))BIS(1-((3, 4-DIMETHOXYPHENYL)METHYL)-1, 2, 3, 4-TETRAHYDRO

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Solubilizes fats for absorption in the intestines.Water-soluble ionic detergent useful for extraction of membrane receptors and other plasma membrane proteins. Reported to induce tyrosine phosphorylation of β-catenin and its subsequent translocation to th

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Canonical Smiles: CC(CCC(=O)[O-])C1CCC2C1(C(CC3C2CCC4C3(CCC(C4)O)C)O)C.[Na+]
• IUPAC Name: sodium;(4R)-4-[(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoate
• InChIKey: FHHPUSMSKHSNKW-SMOYURAASA-M
• INCHI: 1S/C24H40O4.Na/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3;/h14-21,25-26H,4-13H2,1-3H3,(H,27,28);/q;+1/p-1/t14-,15-,16-,17+,18-,19+,20+,21+,23+,24-;/m1./s1
• Isomeric SMILES: C[C@H](CCC(=O)[O-])[C@H]1CC[C@@H]2[C@@]1([C@H](C[C@H]3[C@H]2CC[C@H]4[C@@]3(CC[C@H](C4)O)C)O)C.[Na+]
• WGK Germany: 3
• RTECS: FZ2250000
• PubChem CID: 23668196
• Molecular Weight: 414.56
• Beilstein: 3581950

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Lipids and lipid-like molecules
    • Class Steroids and steroid derivatives
      • Subclass Bile acids, alcohols and derivatives
        • Level5 Hydroxy bile acids, alcohols and derivatives
          • Level6 Dihydroxy bile acids, alcohols and derivatives

• Kingdom: Organic compounds
• Superclass: Lipids and lipid-like molecules
• Class: Steroids and steroid derivatives
• Subclass: Bile acids, alcohols and derivatives
• Intermediate Tree Nodes: Hydroxy bile acids, alcohols and derivatives
• Direct Parent: Dihydroxy bile acids, alcohols and derivatives
• Alternative Parents: 3-alpha-hydroxysteroids 12-hydroxysteroids Secondary alcohols Cyclic alcohols and derivatives Carboxylic acid salts Monocarboxylic acids and derivatives Carboxylic acids Organic zwitterions Organic sodium salts Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic homopolycyclic compounds
• Substituents: Dihydroxy bile acid, alcohol, or derivatives - 3-hydroxysteroid - 12-hydroxysteroid - Hydroxysteroid - 3-alpha-hydroxysteroid - Cyclic alcohol - Carboxylic acid salt - Secondary alcohol - Carboxylic acid derivative - Carboxylic acid - Organic alkali metal salt - Monocarboxylic acid or derivatives - Organic sodium salt - Hydrocarbon derivative - Alcohol - Organic oxide - Organic oxygen compound - Organic salt - Carbonyl group - Organooxygen compound - Organic zwitterion - Aliphatic homopolycyclic compound
• Description: This compound belongs to the class of organic compounds known as dihydroxy bile acids, alcohols and derivatives. These are compounds containing or derived from a bile acid or alcohol, and which bears exactly two carboxylic acid groups.
• External Descriptors: bile acid salt

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

NR3C1 Tclin Glucocorticoid receptor (14987 Activities)

Discover Target: NR3C1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PPARG Tclin Peroxisome proliferator-activated receptor gamma (15191 Activities)

Discover Target: PPARG

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RXRA Tclin Retinoid X receptor alpha (3637 Activities)

Discover Target: RXRA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GSTO1 Tchem Glutathione transferase omega 1 (164 Activities)

Discover Target: GSTO1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Lymphoblastoid cell (5959 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

Discover Target: TDP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GMNN Tbio Geminin (128009 Activities)

Discover Target: GMNN

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Cruzipain (33337 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Ppard Peroxisome proliferator-activated receptor delta (358 Activities)

Discover Target: Ppard

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)

Discover Target: Txnrd1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)

Discover Target: Nfe2l2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rorc Nuclear receptor ROR-gamma (89407 Activities)

Discover Target: Rorc

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Sensitivity: Hygroscopic
• Specific Rotation[α]: 42° (C=2,H2O)
• Molecular Weight: 414.600 g/mol
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 414.275 Da
• Monoisotopic Mass: 414.275 Da
• Topological Polar Surface Area: 80.600 Ų
• Heavy Atom Count: 29
• Formal Charge: 0
• Complexity: 612.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 10
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3

References

1. Jing Zhang, Kairu Liu, Xiaojuan Duan, Xuhao Wang, Wupeng Ge, Wenping Jin.  (2023)  Restoration of Choujiu Koji and evaluation of its brewing performance.  LWT-FOOD SCIENCE AND TECHNOLOGY,      [PMID:] [10.1016/j.lwt.2023.114933]

2. Peng Weichao, Yan Shuaihu, Zhou Ke, Wu Hai-Chen, Liu Lei, Zhao Yuliang.  (2023)  High-resolution discrimination of homologous and isomeric proteinogenic amino acids in nanopore sensors with ultrashort single-walled carbon nanotubes.  Nature Communications,  14  (1): (1-8).  [PMID:37160961] [10.1038/s41467-023-38399-4]

3. Sheng Liu, Bo Yang, Yingxiang Hou, Kaige Cui, Xiaozhu Yang, Xiaoxiong Li, Lianwan Chen, Shichao Liu, Zhichao Zhang, Yuanyuan Jia, Yufeng Xie, Ying Xue, Xiaomei Li, Bingxue Yan, Changxin Wu, Wen Deng, Jianxun Qi, Defen Lu, George F. Gao, Peiyi Wang, Guijun Shang.  (2023)  The mechanism of STING autoinhibition and activation.  MOLECULAR CELL,      [PMID:37086726] [10.1016/j.molcel.2023.03.029]

4. Qin Guo, Jie Cai, Pengyu Li, Dongling Xu, Xiaomin Ni, Hui Wen, Dan Liu, Suizhen Lin, Haiyan Hu.  (2023)  Comparison of bile salt/phosphatidylcholine mixed micelles in solubilization to sterols and stability.  Drug Design Development and Therapy,      [PMID:27895469] [10.2147/DDDT.S119918]

5. Chuntian Shao, Jingwei Zhong, Junwen Liu, Yiyan Yang, Meilin Li, Yang Yu, Yaqin Xu, Libo Wang.  (2022)  Preparation, characterization and bioactivities of selenized polysaccharides from Lonicera caerulea L. fruits.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:36403769] [10.1016/j.ijbiomac.2022.11.105]

6. Shuo Qi, Xiaoze Dong, Yuhan Sun, Yin Zhang, Nuo Duan, Zhouping Wang.  (2022)  Split aptamer remodeling-initiated target-self-service 3D-DNA walker for ultrasensitive detection of 17β-estradiol.  JOURNAL OF HAZARDOUS MATERIALS,      [PMID:35872451] [10.1016/j.jhazmat.2022.129590]

7. Ping Li, Yiting Yang, Zijin Lin, Shijin Hong, Ling Jiang, Han Zhou, Lu Yang, Liang Zhu, Xiaodong Liu, Li Liu.  (2022)  Bile Duct Ligation Impairs Function and Expression of Mrp1 at Rat Blood–Retinal Barrier via Bilirubin-Induced P38 MAPK Pathway Activations.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  23  (14): (7666).  [PMID:35887010] [10.3390/ijms23147666]

8. Wang Cong-Yu, Sun Min, Fan Zhen, Du Jian-Zhong.  (2022)  Intestine Enzyme-responsive Polysaccharide-based Hydrogel to Open Epithelial Tight Junctions for Oral Delivery of Imatinib against Colon Cancer.  CHINESE JOURNAL OF POLYMER SCIENCE,  40  (10): (1154-1164).  [PMID:] [10.1007/s10118-022-2726-0]

9. Chu-tong Tian, Jing-jing Guo, Yi-fan Miao, He-lin Wang, Qing Ye, Chun-lin Guo, Ming-yang Zhang, Zhong-gui He, Jin Sun.  (2022)  Long chain triglyceride-lipid formulation promotes the oral absorption of the lipidic prodrugs through coincident intestinal behaviors.  EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS,      [PMID:35643367] [10.1016/j.ejpb.2022.05.015]

10. Zhang Pengpeng, Zhang Miaomiao, Dong Kaiyu, Zhang Yicong, Yang Shuang, Wang Yuanhong, Jiang Tingfu, Yu Mingming, Lv Zhihua.  (2022)  Evaluation of Chito-Oligosaccharide (COS) in Vitro and in Vivo: Permeability Characterization in Caco-2 Cells Monolayer and Pharmacokinetics Properties in Rats.  Journal of Ocean University of China,  21  (3): (782-788).  [PMID:] [10.1007/s11802-022-5088-x]

11. Yu Luo, Shenyu Huang, Lie Ma.  (2021)  A novel detergent-based decellularization combined with carbodiimide crosslinking for improving anti-calcification of bioprosthetic heart valve.  Biomedical Materials,  16  (4): (045022).  [PMID:33979785] [10.1088/1748-605X/ac0088]

12. Yang Min, Lu Xiaoluan, Tang Luyang, Fu Yangyang, Yang Peixin.  (2020)  Thermosensitive nanocomposite gel loaded zinc phthalocyanine for photodynamic therapy.  JOURNAL OF POLYMER RESEARCH,  27  (9): (1-10).  [PMID:] [10.1007/s10965-020-02253-8]

13. Xinrui Li, Jing Su, Zul Kamal, Pengcheng Guo, Xinyi Wu, Lina Lu, Hongbing Wu, Mingfeng Qiu.  (2020)  Odorranalectin modified PEG–PLGA/PEG–PBLG curcumin-loaded nanoparticle for intranasal administration.  DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY,      [PMID:32375569] [10.1080/03639045.2020.1762202]

14. Zhou Xueqing, Xie Yanli, Zhao Zhendong, Fu Wenyan.  (2020)  A simple strategy based on fibers coated with surfactant-functionalized multiwalled carbon nanotubes to improve the properties of solid-phase microextraction of phenols in aqueous solution.  BMC Chemistry,  14  (1): (1-11).  [PMID:32099973] [10.1186/s13065-020-00665-7]

15. Xuejuan Zhang, Xiao Yue, Yingtong Cui, Ziyu Zhao, Ying Huang, Shihao Cai, Guanlin Wang, Wenhao Wang, Smyth Hugh, Xin Pan, Chuanbin Wu, Wen Tan.  (2020)  A Systematic Safety Evaluation of Nanoporous Mannitol Material as a Dry-Powder Inhalation Carrier System.  JOURNAL OF PHARMACEUTICAL SCIENCES,      [PMID:31987851] [10.1016/j.xphs.2020.01.017]

16. Xiaoluan Lu, Wentao Zhu, Tingyu Chen, Qianrong Peng, Changmu Yu, Min Yang.  (2019)  Exploration of photophysical and photochemical properties of Zinc phthalocyanine-loaded SDC/TPGS mixed micelles.  CHEMICAL PHYSICS LETTERS,      [PMID:] [10.1016/j.cplett.2019.136737]

17. Xu Yingxin, Fang Tianxu, Yang Yifan, Sun Li’ang, Shen Qi.  (2019)  Preparation of Deoxycholate-Modified Docetaxel-Cimetidine Complex Chitosan Nanoparticles to Improve Oral Bioavailability.  AAPS PHARMSCITECH,  20  (7): (1-10).  [PMID:31489504] [10.1208/s12249-019-1520-y]

18. Hailing Yang, Zhenjie Liu, Yonglong Song, Changjiang Hu.  (2019)  Hyaluronic acid-functionalized bilosomes for targeted delivery of tripterine to inflamed area with enhancive therapy on arthritis.  DRUG DELIVERY,      [PMID:31389248] [10.1080/10717544.2019.1636423]

19. Hui Li, Yang Pang, Xin Wang, Xun Cao, Xun He, Kequan Chen, Ganlu Li, Pingkai Ouyang, Weiming Tan.  (2019)  Phospholipase D encapsulated into metal-surfactant nanocapsules for enhancing biocatalysis in a two-phase system.  RSC Advances,  9  (12): (6548-6555).  [PMID:35518461] [10.1039/C8RA09827A]

20. Hui Li, Yan Ni, Xun Cao, Xun He, Ganlu Li, Kequan Chen, Pingkai Ouyang, Jianming Yang, Weiming Tan.  (2019)  Highly active nanobiocatalysis in deep eutectic solvents via metal-driven enzyme-surfactant nanocomposite.  JOURNAL OF BIOTECHNOLOGY,      [PMID:30690095] [10.1016/j.jbiotec.2019.01.010]

21. Li Zhang, Dandan Ren, Jianyu Zhou, Guangneng Peng, Gang Shu, Zhixiang Yuan, Fei Shi, Ling Zhao, Lizi Yin, Guoqing Fan, Chang Liu, Hualin Fu.  (2017)  Toltrazuril mixed nanomicelle delivery system based on sodium deoxycholate–Brij C20 polyethylene ether–triton x100: Characterization, solubility, and bioavailability study.  COLLOIDS AND SURFACES B-BIOINTERFACES,      [PMID:29289823] [10.1016/j.colsurfb.2017.12.018]

22. Weihua Jiang, Ju Wang, Lei Yang, Xuewei Jiang, Zhaoshi Bai, Zheran Wang, Yunpeng He, Dongkai Wang.  (2015)  Nanostructured lipid carriers modified with PEGylated carboxymethylcellulose polymers for effective delivery of docetaxel.  RSC Advances,  5  (110): (90386-90395).  [PMID:] [10.1039/C5RA13642C]

23. Xuesong Kong, Shixiang Feng, Xu Zhang, Yan Li.  (2014)  Effects of bile salts and divalent cations on the adsorption of norfloxacin by agricultural soils.  Journal of Environmental Sciences,      [PMID:25079415] [10.1016/S1001-0742(13)60480-5]

24. Ni Li, Li-Hua Peng, Xi Chen, Shinsaku Nakagawa, Jian-Qing Gao.  (2011)  Effective transcutaneous immunization by antigen-loaded flexible liposome in vivo.  International Journal of Nanomedicine,      [PMID:22228992] [10.2147/IJN.S26152]

25. Chuan Niu, Tian Liu, Liping Yang, Dan Wang, Xiong Xiao, Shaojie Yang, Ziwei Huang, Yuchu Yang, Li Feng.  (2025)  Bifunctional sheets reduce the microbe and endotoxin contamination of tissue-derived collagen.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:39993681] [10.1016/j.ijbiomac.2025.141411]

26. Luo Juan, Yu Yao, Wang Ke, He Sizhe, Wang Longjie, Liang Fangfang, Chin Jason W., Tang Shan.  (2024)  Capturing acyl–enzyme intermediates with genetically encoded 2,3-diaminopropionic acid for hydrolase substrate identification.  Nature Protocols,      [PMID:38867073] [10.1038/s41596-024-01006-x]

27. Hujun Xie, Xin Luo, Ying Gao, Min Huang, Gerui Ren, Rongmi Zhou, Yulu Sun, Haoxin Ye, Qunfang Lei, Wenjun Fang, Yong-Quan Xu.  (2024)  Co-encapsulation of Lactobacillus plantarum and EGCG: A promising strategy to increase the stability and lipid-lowering activity.  FOOD HYDROCOLLOIDS,      [PMID:] [10.1016/j.foodhyd.2024.109768]

28. Xinyuan Yan, Juan Chai, Luohao Yuan, Hongfeng Yin.  (2024)  Construction of Pt-GOx@H-ZIF-8 core–shell structure for the detection of glutathione.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2024.110384]

29. Guanliang He, Chuang Zhu, Yuze Shi, Yingjia Yu, Yi Wu, Constantinos Soutis, Le Cao, Xuqing Liu.  (2024)  Development of a Mussel-Inspired Conductive Graphene Coated Cotton Yarn for Wearable Sensors.  iScience,      [PMID:39898041] [10.1016/j.isci.2024.111711]

30. Wang Wenchao, An Lianhao, Lei Junrong, Li Dan, Shen Zheluan, Wang Hong, Li Qingyong.  (2024)  Effects of Different Extraction Methods on Biological Activities of Pearl Powder Extracts.  Chemistry Africa-A Journal of the Tunisian Chemical Society,      [PMID:] [10.1007/s42250-024-00961-y]

31. Wenzhu Kuang, Hongxia Luo, Zhiwei Zhu.  (2024)  Exploring the potential of inherent chiral single-walled carbon nanotubes in enantioselective electrochemical sensing: A novel microsensor for discriminating DOPA enantiomers.  ELECTROCHIMICA ACTA,      [PMID:] [10.1016/j.electacta.2024.144162]

32. Nanting Zhu, Decheng Bi, Jinfeng Huang, Lijun Yao, Yan Wu, Zedong Jiang, Zhangli Hu, Beiwei Zhu, Shuangfei Li, Xu Xu.  (2025)  Genipin crosslinked sodium caseinate-chitosan oligosaccharide nanoparticles for optimizing β-carotene stability and bioavailability.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:39788249] [10.1016/j.ijbiomac.2025.139626]

33. Yingjie Du, Xiuyan Luo, Xiaohong Ye, Meijia Song, Yingjia Li, Shumao Yang, Caoxing Huang, Jiandong Cui.  (2025)  Molecular imprinted photoresponse hybrid biocatalyst for ultrasensitive glutamate detection.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:40147642] [10.1016/j.ijbiomac.2025.142540]

34. Chen Xianghang, Wang Beini, Al Mamun Abdullah, Du Kaiyi, Wang Shengfu, Hu Qianqian, Chen Xinyuan, Lu Yang, Du Anyu, Wu Yueqi, Shao Jiaqin, Wang Shuangshuang, Jiang Chang, Zhou Kailiang, Hu Siwang, Xiao Jian.  (2025)  Pectin-Zein-IPA nanoparticles promote functional recovery and alleviate neuroinflammation after spinal cord injury.  JOURNAL OF NANOBIOTECHNOLOGY,  23  (1): (1-18).  [PMID:40016738] [10.1186/s12951-025-03224-1]

35. Xi Luo, Litian Zhang, Xiaoyuan Xie, Liyan Yuan, Yanqiang Shi, Yinbo Jiang, Wujian Ke, Bin Yang.  (2024)  Phosphorylated vimentin-triggered fibronectin matrix disaggregation enhances the dissemination of Treponema pallidum subsp. pallidum across the microvascular endothelial barrier.  PLoS Pathogens,  20  (9): (e1012483).  [PMID:39226326] [10.1371/journal.ppat.1012483]

36. Xin Tan, Yi Zhou, Yaxin Qin, Linjie Wu, Ruizhi Yang, Xiaoyan Bao, Ruolin Jiang, Xiaoyan Sun, Xufang Ying, Zhiqing Ben, Qi Dai, Zhicheng Zhang, Kai Zeng, Min Han.  (2024)  Self-Healing Hydrogel Resulting from the Noncovalent Interaction between Ropivacaine and Low-Molecular-Weight Gelator Sodium Deoxycholate Achieves Stable and Endurable Local Analgesia in Vivo.  ACS Applied Materials & Interfaces,      [PMID:39171973] [10.1021/acsami.4c07883]

37. Faisal Raza, Liangdi Jiang, Shulei Zhang, Hajra Zafar, Yujiao Qiu, Jing Su, Mingfeng Qiu.  (2024)  SP94 engineered erythrocyte membrane enhanced the targeted delivery of biomimetic nanosuspension with IDO immunotherapy and chemotherapy in liver cancer.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2024.151709]

38. Jin Wang, Jie Li, Xiao Luo, Mei-Mei Qu Mo, Jing Feng, Wen-Bing Li, Huiling Yan, Yi-Chen Hu, Liang Zou, Ding-Tao Wu.  (2024)  Structural properties and biological effects of pectic polysaccharides extracted from Tartary buckwheat sprouts by high pressure-assisted deep eutectic solvent extraction.  LWT-FOOD SCIENCE AND TECHNOLOGY,      [PMID:] [10.1016/j.lwt.2024.116397]

39. Te Yu, Yonggang Dai, Zifei Wang, Yang Gao, Qiong Wu.  (2025)  Ultrasound-induced modifications of Auricularia auricula polysaccharides: Implications for antioxidant and glucose-lowering activities.  Food Chemistry-X,      [PMID:39974537] [10.1016/j.fochx.2025.102209]

40. Rongmi Zhou, Fangfang Ni, Shiyi Wu, Xinyu Wang, Jing Ming, Lantong Zhang, Lijuan Dong, Zhijun Song, Gerui Ren, Min Huang, Shuangbin Xu, Qiong Zhang, Khaled F. El-Massry, Hujun Xie.  (2025)  Preparation and mechanism of Lactobacillus plantarum and curcumin co-encapsulated in alginate-gelatin hydrogel beads.  FOOD CHEMISTRY,      [PMID:40840394] [10.1016/j.foodchem.2025.145995]

41. Sen-Lin Zhu, Yu-Nan Yan, Ming-Hui Jia, Hou-Cheng Li, Bo Han, Tao Shi, Lian-Bin Xu, Xiao-Wen Wang, Qi Zhang, Wei-Jie Zheng, Jing-Hong Xu, Liang Chen, Wenlingli Qi, Sheng-Jun Cai, Xin-Peng Chen, Feng-Fei Gu, Jian-Xin Liu, George E. Liu, Yu Jiang, Dong-Xiao Sun, Ling-Zhao Fang, Hui-Zeng Sun.  (2025)  Antioxidants promote metabolic remodeling in cattle rumen epithelium revealed by single-cell resolution.  iMeta,  4  (6): (e70100).  [PMID:] [10.1002/imt2.70100]

42. He Ying, Huang Ao, Liu Yun.  (2025)  A New Phospholipase D-Producing Bacillus cereus: Taxonomy, Mutagenesis, Fermentation Optimization and Enzyme Characterization.  APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY,      [PMID:40392408] [10.1007/s12010-025-05278-1]

43. Wenbin Nan, Hao Wang, Linxiao Li, Jiulong Du, Xiangjuan Wei, Dongmei Wang, Yan Yang, Yongxue Wang, Dan Ding, Hongli Chen.  (2025)  Microneedles incorporating oridonin micelles and Cu(II)-polydopamine provide effective inflammatory regulation and antibacterial effects for the healing of infected diabetic wounds.  COLLOIDS AND SURFACES B-BIOINTERFACES,      [PMID:40446540] [10.1016/j.colsurfb.2025.114814]

44. Kaijun Li, Qinsheng Hu, Ling Wang, Chengcheng Wu, Li Yang, Gongyan Liu, Yunbing Wang.  (2025)  Engineering of Bioprosthetic Heart Valves with Synergistic Zwitterionic Surface Modification and Zirconium Cross-linking for Improved Biocompatibility and Durability.  Acta Biomaterialia,      [PMID:40490240] [10.1016/j.actbio.2025.06.010]

45. Yan Gong, Qiurong Sun, Gao He, Jiarui Wang, Dequan Xiao, Lile Dong.  (2025)  Ultrasound-accelerated Ti3FeBi5O15 nanosheets amplify reactive oxygen species storms/ferroptosis to trigger antitumor immunotherapy.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2025.169689]

46. Ningqiang Shi, Xiaofei Xiao, Mingyu Zhang, Zhijun Li, Chuncheng Ban, Jinchang Meng, Nannan Shi, Mingyang Wu, Zebo Zheng, Ling Li.  (2025)  Multifunctional Infrared Polarizer Based on Aligned Growth of High-Density Boron Nitride Nanotubes.  Advanced Science,  12  (30): (e01908).  [PMID:40464600] [10.1002/advs.202501908]

47. Jingjie Zhang, Yanmin Chen, Zhenyi Lin, Changhua Xu, Lijuan Zhu, Chuan Zhang.  (2026)  Nanoliposomal Co-Delivery of AR-PROTAC and NFKBIZ siRNA for Synergistic Therapy of Androgenetic Alopecia.  ACS Applied Bio Materials,      [PMID:41532459] [10.1021/acsabm.5c02176]

48. Jieying Zhou, Wei Luo, Lingxin Zeng, Shihao Xu, Ruohan Wu, Jiaqi Lu, Ying Li, Wei Xiong.  (2026)  A Bubble-Driven Drug Delivery System Enhances Oral Absorption and Antipyretic Efficacy of Poorly Water-Soluble Andrographolide.  International Journal of Nanomedicine,      [PMID:] [10.2147/IJN.S574265]