2-Hydroxy-1-naphthoic Acid - ≥98% , CAS No.2283-08-1

CAS: 2283-08-1 Cat. No.: H157161 Molecular Weight: 188.18 EC Number: 218-919-2

GRADE & PURITY ≥98%

Synonyms

2-hydroxy-1-napthoic acid | 2-hydroxy-l-naphthoic acid | DTXSID9062304 | AI3-19839 | 1-Naphthalenecarboxylic acid, 2-hydroxy- | E3H4QZ94UY | FT-0612523 | 1-NAPHTHOIC ACID, 2-HYDROXY- | 2-hydroxy-1-naphtoic acid | 3-(5-PHENYL-2-FURYL)PROPANOICACID | Q27276

Storage

Room temperature,Desiccated,Cool

Shipped In

Normal

Specifications

Synonyms

2-hydroxy-1-napthoic acid | 2-hydroxy-l-naphthoic acid | DTXSID9062304 | AI3-19839 | 1-Naphthalenecarboxylic acid, 2-hydroxy- | E3H4QZ94UY | FT-0612523 | 1-NAPHTHOIC ACID, 2-HYDROXY- | 2-hydroxy-1-naphtoic acid | 3-(5-PHENYL-2-FURYL)PROPANOICACID | Q27276

Specifications & Purity

≥98%

Storage

Room temperature, Desiccated, Cool

Shipped In

Normal

Purity

≥98%

Names and Identifiers

• Pubchem Sid: 488182293
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488182293
• Canonical Smiles: C1=CC=C2C(=C1)C=CC(=C2C(=O)O)O
• IUPAC Name: 2-hydroxynaphthalene-1-carboxylic acid
• InChIKey: UPHOPMSGKZNELG-UHFFFAOYSA-N
• INCHI: 1S/C11H8O3/c12-9-6-5-7-3-1-2-4-8(7)10(9)11(13)14/h1-6,12H,(H,13,14)
• Isomeric SMILES: C1=CC=C2C(=C1)C=CC(=C2C(=O)O)O
• Molecular Weight: 188.18
• Reaxy-Rn: 975575
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=975575&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Class Naphthalenes
      • Subclass Naphthalenecarboxylic acids and derivatives

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Class: Naphthalenes
• Subclass: Naphthalenecarboxylic acids and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Naphthalenecarboxylic acids
• Alternative Parents: Naphthols and derivatives Salicylic acid and derivatives 1-hydroxy-2-unsubstituted benzenoids Vinylogous acids Monocarboxylic acids and derivatives Carboxylic acids Organooxygen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic homopolycyclic compounds
• Substituents: 1-naphthalenecarboxylic acid - 2-naphthol - Salicylic acid or derivatives - Hydroxybenzoic acid - 1-hydroxy-2-unsubstituted benzenoid - Vinylogous acid - Monocarboxylic acid or derivatives - Carboxylic acid - Carboxylic acid derivative - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Aromatic homopolycyclic compound
• Description: This compound belongs to the class of organic compounds known as naphthalenecarboxylic acids. These are compounds containing a naphthalene moiety, which bears a carboxylic acid group one or more positions. Naphthalene is a bicyclic compound that is made up of two fused benzene ring.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

ERN1 Tchem Serine/threonine-protein kinase/endoribonuclease IRE1 (1682 Activities)

Discover Target: ERN1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP73A16 Trans-cinnamate 4-monooxygenase (45 Activities)

Discover Target: CYP73A16

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Melt Point(°C): 167 °C(dec.)
• Molecular Weight: 188.180 g/mol
• XLogP3: 2.900
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 188.047 Da
• Monoisotopic Mass: 188.047 Da
• Topological Polar Surface Area: 57.500 Ų
• Heavy Atom Count: 14
• Formal Charge: 0
• Complexity: 227.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Shanshan Sun, Haizhen Wang, Binxin Fu, Hao Zhang, Jun Lou, Laosheng Wu, Jianming Xu.  (2019)  Non-bioavailability of extracellular 1-hydroxy-2-naphthoic acid restricts the mineralization of phenanthrene by Rhodococcus sp. WB9.  SCIENCE OF THE TOTAL ENVIRONMENT,      [PMID:31831232] [10.1016/j.scitotenv.2019.135331]

2. Zhanpeng Liu, Xiangbo Ding, Lin Cai, Yihan Jia, Xia Ran, Zhongzheng Guo, Dan Mo, Yatao Pan, Lijun Guo.  (2025)  Cascade energy transfer endows phosphorescent carbon dots-based films with tunable and broadband afterglow for fingerprint recognition and anticounterfeiting.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2025.160311]