3-AP-Me , CAS No.1184391-57-8

CAS: 1184391-57-8 Cat. No.: A1416536 Fórmula: C₉H₁₃N₅S Peso molecular: 223.3 Número CE: 808-469-0 PubChem CID: 44235406

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Visão geral

3-AP-Me is a dimethyl derivative of the nucleotide reductase inhibitor 3-AP (SML0568). 3-AP-Me can activate the endoplasmic reticulum (ER) stress pathway by promoting the phosphorylation of eIF2α and increasing the gene expression of transcription factors ATF4 and ATF6 , leading to cell apoptosis. Additionally, 3-AP-Me can activate the stress kinases c-Jun N-terminal kinase ( JNK ) and p38 mitogen-activated protein kinases. 3-AP-Me also leads to the upregulation of the spliced mRNA variant XBP1, can be used in cancer research.

Specifications

Condições de armazenamento de armazenamento

Store at -20°C

Enviado em

Ice chest + Ice pads

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Tipo de ação

ACTIVATOR

Nomes e identificadores

• Sorrisos canónicos: CN(C)C(=S)NN=CC1=C(C=CC=N1)N
• IUPAC Name: 3-[(E)-(3-aminopyridin-2-yl)methylideneamino]-1,1-dimethylthiourea
• InChIKey: DQVSEUUIXQTWRB-WUXMJOGZSA-N
• INCHI: 1S/C9H13N5S/c1-14(2)9(15)13-12-6-8-7(10)4-3-5-11-8/h3-6H,10H2,1-2H3,(H,13,15)/b12-6+
• SMILES isoméricas: CN(C)C(=S)N/N=C/C1=C(C=CC=N1)N
• WGK Alemanha: 3
• PubChem CID: 44235406
• Peso molecular: 223.3

Perguntas frequentes

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1184391-57-8, the molecular formula is C9H13N5S, and the molecular weight is 223.3 g/mol. InChIKey DQVSEUUIXQTWRB-WUXMJOGZSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.