Name: 6-Hydroxydopamine hydrobromide - Moligand™,10mM in DMSO , CAS No.636-00-0
Brand: Aladdin Scientific
SKU: H425227
Availability: InStock

6-Hydroxydopamine hydrobromide - Moligand™,10mM in DMSO , CAS No.636-00-0

CAS: 636-00-0 Cat. No.: H425227 Fórmula: (HO)₃C₆H₂CH₂CH₂NH₂ · HBr Peso molecular: 250.09 Beilstein Registry Number: 3713280 Número CE: 211-247-0

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6-Hydroxydopamine hydrobromide - 10mM in DMSO CAS No(636-00-0) by Aladdin Scientific

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Disponível para encomenda

GRAU & PUREZA Moligand™ ? 10mM in DMSO

Synonyms

2,5-Dihydroxytyramine hydrobromide | HY-B1081A | SY102034 | 6-OHDA hydrobromide6-Hydroxydopamine hydrobromide | 5-(2-aminoethyl)benzene-1,2,4-triol;hydrobromide | BCP25700 | NSC238469 | NSC-238469 | TWC1D4W0WB | EINECS 217-598-6 | 636-00-0 (HBr) | Q272904

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Folha de especificações

Visão geral Especificações Nomes e identificadores Documentação Dados avançados Taxonomic Classification Estrutura 3D Alvos associados (humanos) Alvos associados (não humanos) Mecanismos de ação Certificados（CoA,COO,BSE/TSE e Mapa de Análise) Propriedades químicas e físicas FAQs e artigos Citations of This Product Calculadoras de soluções Revisões

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Por que este grau

Moligand™,10mM in DMSO Moligand™ para fluxos de trabalho cromatográficos e analíticos sensíveis que exigem interferência mínima da linha de base.

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Armazenamento e envio

Store at -80°C Envio Dry ice packs + Cold packs. Consulte o COA específico do lote para obter as especificações exatas.

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Documentos de qualidade

SDS, COA, ficha técnica e folha de especificações disponíveis para download. COA específico do lote acessível por meio de pesquisa por número de lote.

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Comprovação documental

Citado em 9 publicações revisadas por pares nas áreas de cromatografia, síntese orgânica e reações de acoplamento cruzado.

Visão geral

Solutions should be freshly prepared and protected from exposure to light.
6-Hydroxydopamine hydrobromide is a neurotoxin which destroys catecholaminergic terminals.

product description：

6-Hydroxydopamine is a selective catecholaminergic neurotoxin. Studies show that 6-Hydroxydopamine can be used to create an animal model of Parkinson's disease as it causes almost complete destruction of nigral dopaminergic neurons and their striatal terminals when injected into the substantia nigra of rats. 6-Hydroxydopamine induces apoptosis in PC12 cells.

Especificações

Sinónimos

Especificações e pureza

Moligand™,10mM in DMSO

Mecanismos bioquímicos e fisiológicos

Neurotoxin that destroys catecholaminergic terminals.Selective catecholaminergic neurotoxin. Depletes brain catecholamine levels. Induces apoptosis in PC-12 cells.\xa0Destroys\xa0nigral dopaminergic neurons and their striatal terminals\xa0in rat models of

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Grau

Moligand™

Nomes e identificadores

Pubchem Sid

528762568

Sorrisos canónicos

C1=C(C(=CC(=C1O)O)O)CCN.Br

IUPAC Name

5-(2-aminoethyl)benzene-1,2,4-triol;hydrobromide

InChIKey

MLACDGUOKDOLGC-UHFFFAOYSA-N

INCHI

1S/C8H11NO3.BrH/c9-2-1-5-3-7(11)8(12)4-6(5)10;/h3-4,10-12H,1-2,9H2;1H

SMILES isoméricas

C1=C(C(=CC(=C1O)O)O)CCN.Br

WGK Alemanha

RTECS

DC4600000

Peso molecular

250.09

Beilstein

3713280

Reaxy-Rn

3713280

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3713280&ln=

Documentação

📋 Ficha de dados de segurança (FDS)

Documento abrangente sobre perigos, manuseamento, armazenamento e conformidade regulamentar.

<<<<<<< HEAD Baixar SDS → ======= Baixar SDS → >>>>>>> release248-p3

✅ Certificado de análise (COA)

Dados de qualidade específicos do lote. Introduza o número de lote para obter o COA exato.

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📊 Ficha técnica

Resumo de referência rápida das especificações e aplicações do produto.

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🔬 Folha de especificações

Atributos de qualidade completos e critérios de aceitação para este grau.

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Dados avançados

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Classe Phenols
    - Subclass Benzenediols
      - Level5 Catechols
        Level6 Catecholamines and derivatives

Kingdom	Organic compounds
Superclass	Benzenoids
Classe	Phenols
Subclass	Benzenediols
Intermediate Tree Nodes	Catechols
Direct Parent	Catecholamines and derivatives
Alternative Parents	Phenethylamines Hydroxyquinols and derivatives 2-arylethylamines Aralkylamines 1-hydroxy-2-unsubstituted benzenoids Polyols Organopnictogen compounds Monoalkylamines Hydrocarbon derivatives Hydrobromides
Molecular Framework	Aromatic homomonocyclic compounds
Substituents	Catecholamine - Hydroxyquinol derivative - Phenethylamine - 2-arylethylamine - 1-hydroxy-2-unsubstituted benzenoid - Aralkylamine - Monocyclic benzene moiety - Polyol - Primary amine - Amine - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Primary aliphatic amine - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Hydrobromide - Aromatic homomonocyclic compound
Descrição	This compound belongs to the class of organic compounds known as catecholamines and derivatives. These are compounds containing 4-(2-Aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] or a derivative thereof formed by substitution.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Estrutura 3D

Alvos associados (humanos)

VDR Tclin Vitamin D receptor (26531 Activities)

Discover Target: VDR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PLK1 Tchem Serine/threonine-protein kinase PLK1 (28605 Activities)

Discover Target: PLK1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PIN1 Tchem Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (36611 Activities)

Discover Target: PIN1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

FEN1 Tchem Flap endonuclease 1 (12055 Activities)

Discover Target: FEN1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

POLK Tbio DNA polymerase kappa (8653 Activities)

Discover Target: POLK

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

POLI Tchem DNA polymerase iota (116820 Activities)

Discover Target: POLI

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

POLH Tchem DNA polymerase eta (21678 Activities)

Discover Target: POLH

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

G6PD Tchem Glucose-6-phosphate 1-dehydrogenase (778 Activities)

Discover Target: G6PD

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM4A Tchem Lysine-specific demethylase 4A (52245 Activities)

Discover Target: KDM4A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

Discover Target: TDP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ERG Tbio Transcriptional regulator ERG (5589 Activities)

Discover Target: ERG

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EYA2 Tbio Eyes absent homolog 2 (5884 Activities)

Discover Target: EYA2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GMNN Tbio Geminin (128009 Activities)

Discover Target: GMNN

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)

Discover Target: CBX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (22556 Activities)

Discover Target: USP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RGS4 Tchem Regulator of G-protein signaling 4 (13867 Activities)

Discover Target: RGS4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RAPGEF3 Tchem Rap guanine nucleotide exchange factor 3 (15528 Activities)

Discover Target: RAPGEF3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GLS Tchem Glutaminase kidney isoform, mitochondrial (16997 Activities)

Discover Target: GLS

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

WRN Tbio Werner syndrome ATP-dependent helicase (8824 Activities)

Discover Target: WRN

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Alvos associados (não humanos)

Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)

Discover Target: Txnrd1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

G6PD-6PGL Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase (1761 Activities)

Discover Target: G6PD-6PGL

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de ação

Certificados（CoA,COO,BSE/TSE e Mapa de Análise)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Propriedades químicas e físicas

Sensibilidade	Light&Moisture sensitive
Ponto de fusão (°C)	216-220°C
Peso molecular	250.090 g/mol
XLogP3
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	2
Exact Mass	249 Da
Monoisotopic Mass	249 Da
Topological Polar Surface Area	86.700 Å²
Heavy Atom Count	13
Formal Charge	0
Complexity	142.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

FAQs e artigos

Establishment of Common Animal Disease Models and Their Experimental Methods

Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides

Tags:

Hypertension Modeling Colitis-Associated Colorectal Cancer (Cac) Modeling Liver Tumor Modeling Acute Kidney Injury (Aki) Modeling Parkinson’S Disease Modeling Alzheimer’S Disease Modeling Diabetes Modeling Hyperlipidemia Modeling Hyperuricemia Modeling Immune/Inflammation Modeling Inducible Gene Regulation Models

Citations of This Product

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Revisões

📚 Citações por aplicação

Topical & ophthalmic formulation1

Controlled-release & nanoparticle carrier1

Other applications4

Organic synthesis — reaction medium2

Extraction & workup solvent2

Drug / compound screening3

Cytotoxicity screening3

Cell viability1

IC50 determination1

Ver todas as 9 citações →

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