10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Visão geral
6RK73 is a covalent irreversible and specific UCHL1 inhibitor with an IC 50 of 0.23 µM. 6RK73 shows almost no inhibition of UCHL3 (IC 50 =236 µM). 6RK73 specifically inhibit UCHL1 activity in breast cancer
In Vitro
6RK73 (5 μM; 1-3 hours) treatment displays strong inhibition of the TGFβ-induced pSMAD2 and pSMAD3, and a decrease of TβRI and total SMAD protein levels in MDA-MB-436 cells. ?\n6RK73(5 μM; 24-48 hours) results migration significantly slower than the DMSO control group in MDA-MB-436 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: MDA-MB-436 cells Concentration: 5 µM Incubation Time: 24, 48 hours Result: Migrated significantly slower than the DMSO control group Western Blot AnalysisCell Line: MDA-MB-436 cells Concentration: 5 µM Incubation Time: 1, 2, 3 hours Result: Displayed strong inhibition of the TGFβ-induced pSMAD2 and pSMAD3, and a decrease of TβRI and total SMAD protein levels.
In Vivo
6RK73 displays a potent inhibition of breast cancer extravasation in zebrafish . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
6RK73 is a covalent irreversible and specific UCHL1 inhibitor with an IC 50 of 0.23 µM. 6RK73 shows almost no inhibition of UCHL3 (IC 50 =236 µM). 6RK73 specifically inhibit UCHL1 activity in breast cancer.
Condições de armazenamento de armazenamento
Store at -80°C
Enviado em
Dry ice packs + Cold packs
Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.
Tipo de ação
INHIBITOR
Nomes e identificadores
SMILES isoméricas
C1CN(C[C@H]1C(=O)NC2=NC=C(S2)N3CCOCC3)C#N
PubChem CID
121248200
Peso molecular
307.37
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
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Revisões
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Perguntas frequentes
How should this product be stored?
Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.
How is this product shipped?
This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.
What are the CAS number, molecular formula and molecular weight?
The CAS Number is 1895050-66-4, the molecular formula is C13H17N5O2S, and the molecular weight is 307.37 g/mol.
What documentation is provided?
Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.
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