9-PAHSA - Moligand™, ≥95% , CAS No.1481636-31-0

CAS: 1481636-31-0 Cat. No.: P467538 Fórmula: C₃₄H₆₆O₄ Peso molecular: 538.89 PubChem CID: 72189985

GRADE & PURITY Moligand™, ≥95%

Synonyms

palmitic-acid-9-hydroxy-stearic-acid

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Visão geral

Description

Palmitic-acid-9-hydroxy-stearic-acid (9-PAHSA) is an isomeric form of bioactive fatty acid ester of hydroxyl-fatty acid (FAHFA).9-PAHSA is composed of palmitic acid attached to stearic acid and is in the class of branched lipids referred to as fatty acid esters of hydroxy fatty acids (FAHFAs). 9-PAHSA was found at increased levels in serum and white adipose tissue of insulin-sensitive mice. Levels were found to be lower in white adipose tissue of insulin-resistant humans. Studies of oral administration of 9-PAHSA to obese, diabetic mice showed improved glucose tolerance. In characterizing the mechanism, it was found that 9-PAHSA stimulates insulin and GLP-1 secretion and also enhances glucose transport and the Glut4 transporter through activation of GPR-120. 9-PAHSA was also shown to haveanti-inflammatory properties.

Specifications

Sinónimos

palmitic-acid-9-hydroxy-stearic-acid

Especificações e pureza

Moligand™, ≥95%

Condições de armazenamento de armazenamento

Store at -20°C

Enviado em

Ice chest + Ice pads

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Grau

Moligand™

Pureza

≥95%

Nomes e identificadores

• Pubchem Sid: 508810285
• SMILES isoméricas: CCCCCCCCCCCCCCCC(=O)OC(CCCCCCCCC)CCCCCCCC(=O)O
• PubChem CID: 72189985
• Peso molecular: 538.89

Alvos associados (humanos)

Caco-2 (12174 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

A549 (127892 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de ação

Propriedades químicas e físicas

• Ponto de fusão (°C): 33.5 °C
• Peso molecular: 538.900 g/mol
• XLogP3: 14.200
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 32
• Exact Mass: 538.496 Da
• Monoisotopic Mass: 538.496 Da
• Topological Polar Surface Area: 63.600 Ų
• Heavy Atom Count: 38
• Formal Charge: 0
• Complexity: 505.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1