O JavaScript parece estar desativado no seu browser. Para usufruir da melhor experiência no nosso site, certifique-se que ativa o JavaScript no seu browser.

Alternar navegação

Carrinho

Pesquisar

Encomenda rápida SDS / CoA Estrutura Bulk & Personalizado

Comparar produtos

Conta

Configurações

Idioma

྾

340,000+ produtos de pesquisa · Triple ISO certified · COA & SDS Disponível para todos os produtos · Envio no mesmo dia em itens em estoque

Início
Por alvo / caminho / doença
Por vias de sinalização
Apoptose
Caspase
Ac-FLTD-CMK - ≥98% , CAS No.2376255-48-8

Ac-FLTD-CMK - ≥98% , CAS No.2376255-48-8

Name: Ac-FLTD-CMK - ≥98% , CAS No.2376255-48-8
SKU: A414490
Availability: InStock

CAS: 2376255-48-8 Cat. No.: A414490 Fórmula: C₂₆H₃₇ClN₄O₈ Peso molecular: 569.05

COA

Saltar para o final da Galeria de imagens

Ac-FLTD-CMK - ≥98% CAS No(2376255-48-8) by Aladdin Scientific

Saltar para o início da Galeria de imagens

Disponível para encomenda

GRADE & PURITY ≥98%

Synonyms

N-acetyl-Phe-Leu-Thr-Asp-chloromethylketone

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Visão geral Specifications Nomes e identificadores Documentation Advanced Data Estrutura 3D Certificados（CoA,COO,BSE/TSE e Mapa de Análise) Propriedades químicas e físicas Calculadoras de soluções Revisões

🧪

Why this grade

≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Protected from light,Store at -20°C,Argon charged Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Visão geral

Information

Ac-FLTD-CMK is a specific inhibitor for inflammatory caspases . Ac-FLTD-CMK inhibits gasdermin D (GSDMD) cleavage by caspases-1, -4, -5, and -11 in vitro. Ac-FLTD-CMK is effective against caspases-1, caspases-4 and caspases-5 with IC50 of 46.7 nM, 1.49 μM and 329 nM, respectively.

Targets

caspases-1 (Cell-free assay); caspases-5 (Cell-free assay); caspases-4 (Cell-free assay) 46.7 nM; 329 nM; 1.49 μM

In vitro

A GSDMD-derived inhibitor, N-acetyl-Phe-Leu-Thr-Asp-chloromethylketone (Ac-FLTD-CMK), inhibits GSDMD cleavage in vitro and suppresses pyroptosis downstream of both canonical and noncanonical inflammasomes.

In vivo

Ac-FLTD-CMK inhibits pyroptosis and exerts neuroprotective effect in a mice model of traumatic brain injury.

Cell Research(from reference)

Cell lines：BMDM cells

Concentrations：10 μM

Incubation Time：30 mins

Specifications

Sinónimos

N-acetyl-Phe-Leu-Thr-Asp-chloromethylketone

Especificações e pureza

≥98%

Condições de armazenamento de armazenamento

Protected from light,Store at -20°C,Argon charged

Enviado em

Ice chest + Ice pads

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Tipo de ação

INHIBITOR

Pureza

≥98%

Nomes e identificadores

Pubchem Sid

528763243

Sorrisos canónicos

CC(C)CC(C(=O)NC(C(C)O)C(=O)NC(CC(=O)O)C(=O)CCl)NC(=O)C(CC1=CC=CC=C1)NC(=O)C

IUPAC Name

(3S)-3-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-acetamido-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-5-chloro-4-oxopentanoic acid

InChIKey

UCWNTWGHVCSMJP-WPUDHWPRSA-N

INCHI

1S/C26H37ClN4O8/c1-14(2)10-19(30-24(37)20(28-16(4)33)11-17-8-6-5-7-9-17)25(38)31-23(15(3)32)26(39)29-18(12-22(35)36)21(34)13-27/h5-9,14-15,18-20,23,32H,10-13H2,1-4H3,(H,28,33)(H,29,39)(H,30,37)(H,31,38)(H,35,36)/t15-,18+,19+,20+,23+/m1/s1

Peso molecular

569.05

Reaxy-Rn

57566578

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=57566578&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Estrutura 3D

Certificados（CoA,COO,BSE/TSE e Mapa de Análise)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

6 results found

Lot Number	Certificate Type	Data	Item
B2423466	Certificate of Analysis	Jan 15, 2024	A414490
B2423763	Certificate of Analysis	Jan 15, 2024	A414490
B2423764	Certificate of Analysis	Jan 15, 2024	A414490
B2423765	Certificate of Analysis	Jan 15, 2024	A414490
B2423767	Certificate of Analysis	Jan 15, 2024	A414490
B2423768	Certificate of Analysis	Jan 15, 2024	A414490

Propriedades químicas e físicas

Solubilidade	Solubility (25°C) In vitro DMSO: 100 mg/mL (175.73 mM); Ethanol: 25 mg/mL (43.93 mM); Water: 2 mg/mL (3.51 mM);
Sensibilidade	Hygroscopic ;Light sensitive

Calculadoras de soluções

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

Reconstitution Calculator

Revisões

Bulk & Custom Packaging Need larger quantities or custom specifications? Contact our team for a tailored quote.

Deseja que lhe enviemos uma mensagem quando tivermos descontos disponíveis?

Lembrar-me mais tarde

Obrigado! Por favor, verifique a sua caixa de entrada de e-mail para confirmar.

Ops! As notificações estão desativadas.

Products are supplied to verified businesses, institutions, and qualified professionals for research and development use only. Not for use in humans, animals, diagnosis, or therapy.