Actinomycin D (Dactinomycin) - 10mM in DMSO , CAS No.50-76-0

CAS: 50-76-0 Cat. No.: A408625 Fórmula: C₆₂H₈₆N₁₂O₁₆ Peso molecular: 1255.42 Número CE: 200-063-6

GRAU & PUREZA 10mM in DMSO

Synonyms

Act D, RASP-101 | Actinomycin D

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs,FedEx DG Service

Visão geral

Information

Actinomycin D (Dactinomycin) Actinomycin D (Dactinomycin, Act D, RASP-101) is a significant polypeptide antibiotic isolated from soil bacteria of the genus Streptomyces. Actinomycin D (Dactinomycin) inhibits DNA repair and rests the cell cycle at G1 pha
In vitro

Actinomycin D markedly reduces the SMC proliferation via the inhibition of BrdU incorporation at 80 nM. This is further supported by the G1-phase arrest using a flowcytometric analysis. The protein expression levels of proliferating cell nuclear antigen (PCNA), focal adhesion kinase (FAK), and Raf are all suppressed by actinomycin D. Extracellular signalregulated kinases (Erk) involved in cell-cycle arrest are found to be increased by actinomycin D.

In vivo

Actinomycin D targets survival proteins TOSO, BCL2 and MCL1 and is active in two different mouse models that are characterized by either unmutated B-cell receptor or inactive p53 function, both of which are known negative prognostic factors in CLL.
Cell Data

cell lines：Ba/F3 cells

Concentrations：80 nM, 800 nM, 8 μM

Incubation Time：18-24 h

Powder Purity:≥98%

Especificações

Sinónimos

Act D, RASP-101 | Actinomycin D

Especificações e pureza

10mM in DMSO

Mecanismos bioquímicos e fisiológicos

Actinomycin D (Dactinomycin, Act D, RASP-101) is a significant polypeptide antibiotic isolated from soil bacteria of the genus Streptomyces. Actinomycin D (Dactinomycin) inhibits DNA repair and rests the cell cycle at G1 phase with IC50 of 0.42 μM and 0.4

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs,FedEx DG Service

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Propriedades do produto

ALogP

3.8

Nomes e identificadores

SMILES isoméricas

C[C@@H]1[C@@H](C(=O)N[C@@H](C(=O)N2CCC[C@H]2C(=O)N(CC(=O)N([C@H](C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)N[C@H]6[C@H](OC(=O)[C@@H](N(C(=O)CN(C(=O)[C@@H]7CCCN7C(=O)[C@H](NC6=O)C(C)C)C)C)C(C)C)C)N)C

Número UN

2811

Grupo de embalagem

I

Peso molecular

1255.42

Reaxy-Rn

1071183

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1071183&ln=

Propriedades químicas e físicas

• Ponto de fusão (°C): 251-253°C