AdipoRon - 10mM in DMSO , CAS No.924416-43-3

CAS: 924416-43-3 Cat. No.: A426942 Fórmula: C₂₇H₂₈N₂O₃ Peso molecular: 428.52 Número CE: 809-728-0

GRADE & PURITY 10mM in DMSO

Synonyms

AdipoRon|924416-43-3|2-(4-benzoylphenoxy)-N-(1-benzylpiperidin-4-yl)acetamide|SC-396658|ND7UVH6GKJ|CHEMBL3393145|2-(4-Benzoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]acetamide|MFCD08271060|2-(4-Benzoylphenoxy)-N-(1-(phenylmethyl)-4-piperidinyl)acetamide

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

Specifications

Sinónimos

AdipoRon | 924416-43-3 | 2-(4-benzoylphenoxy)-N-(1-benzylpiperidin-4-yl)acetamide | SC-396658 | ND7UVH6GKJ | CHEMBL3393145 | 2-(4-Benzoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]acetamide | MFCD08271060 | 2-(4-Benzoylphenoxy)-N-(1-(phenylmethyl)-4-piperidinyl)acetamide

Especificações e pureza

10mM in DMSO

Mecanismos bioquímicos e fisiológicos

Adiponectin receptor agonist (K D values are 1.8 and 3.1 μM for AdipoR1 and AdipoR2, respectively). AMPK and PPARα signaling activator. Shows antiobesogenic, antidiabetic and cardioprotective effects in vivo. Orally active.

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Nomes e identificadores

• Pubchem Sid: 528776343
• Sorrisos canónicos: C1CN(CCC1NC(=O)COC2=CC=C(C=C2)C(=O)C3=CC=CC=C3)CC4=CC=CC=C4
• IUPAC Name: 2-(4-benzoylphenoxy)-N-(1-benzylpiperidin-4-yl)acetamide
• InChIKey: SHHUPGSHGSNPDB-UHFFFAOYSA-N
• INCHI: 1S/C27H28N2O3/c30-26(28-24-15-17-29(18-16-24)19-21-7-3-1-4-8-21)20-32-25-13-11-23(12-14-25)27(31)22-9-5-2-6-10-22/h1-14,24H,15-20H2,(H,28,30)
• SMILES isoméricas: C1CN(CCC1NC(=O)COC2=CC=C(C=C2)C(=O)C3=CC=CC=C3)CC4=CC=CC=C4
• Peso molecular: 428.52
• Reaxy-Rn: 26897425
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=26897425&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Classe Benzene and substituted derivatives
      • Subclass Benzophenones

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Classe: Benzene and substituted derivatives
• Subclass: Benzophenones
• Intermediate Tree Nodes: Not available
• Direct Parent: Benzophenones
• Alternative Parents: N-benzylpiperidines Diphenylmethanes Aryl-phenylketones Phenylmethylamines Phenoxy compounds Phenol ethers Benzylamines Benzoyl derivatives Alkyl aryl ethers Aralkylamines Trialkylamines Secondary carboxylic acid amides Amino acids and derivatives Azacyclic compounds Hydrocarbon derivatives Organic oxides
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Benzophenone - Aryl-phenylketone - Diphenylmethane - N-benzylpiperidine - Benzylpiperidine - Phenoxy compound - Benzoyl - Benzylamine - Aryl ketone - Phenol ether - Phenylmethylamine - Alkyl aryl ether - Aralkylamine - Piperidine - Amino acid or derivatives - Carboxamide group - Ketone - Tertiary aliphatic amine - Tertiary amine - Secondary carboxylic acid amide - Ether - Azacycle - Carboxylic acid derivative - Organoheterocyclic compound - Organic nitrogen compound - Amine - Carbonyl group - Hydrocarbon derivative - Organonitrogen compound - Organooxygen compound - Organic oxygen compound - Organic oxide - Aromatic heteromonocyclic compound
• Descrição: This compound belongs to the class of organic compounds known as benzophenones. These are organic compounds containing a ketone attached to two phenyl groups.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Alvos associados (humanos)

ADIPOR1 Tbio Adiponectin receptor protein 1 (1 Activities)

Discover Target: ADIPOR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ADIPOR2 Tbio Adiponectin receptor protein 2 (1 Activities)

Discover Target: ADIPOR2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Alvos associados (não humanos)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mus musculus (284745 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RAW264.7 (28094 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de ação

Propriedades químicas e físicas

• Sensibilidade: light sensitive
• Peso molecular: 428.500 g/mol
• XLogP3: 4.700
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 8
• Exact Mass: 428.21 Da
• Monoisotopic Mass: 428.21 Da
• Topological Polar Surface Area: 58.600 Ų
• Heavy Atom Count: 32
• Formal Charge: 0
• Complexity: 582.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1