Aminophylline - 10mM in DMSO , Adenosine receptor antagonist, CAS No.317-34-0, Adenosine receptor antagonist

CAS: 317-34-0 Cat. No.: A408079 Fórmula: C₁₆H₂₄N₁₀O₄ Peso molecular: 420.43 Número CE: 206-264-5

GRADE & PURITY 10mM in DMSO

Synonyms

Phyllocontin | 3,​9-​dihydro-​1,​3-​dimethyl-1H-​purine-​2,​6-​dione

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

Information

Aminophylline Aminophylline (Phyllocontin) is a competitive nonselective phosphodiesterase inhibitor with an IC50 of 0.12 mM and also a nonselective adenosine receptor antagonist.
In vitro

In vivo

Cell Data

cell lines：UMSCC10B, UMSCC14B, UMSCC17B, UMSCC22B, and UMSCC35, UMSCC38 cell lines

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinónimos

Phyllocontin | 3,​9-​dihydro-​1,​3-​dimethyl-1H-​purine-​2,​6-​dione

Especificações e pureza

10mM in DMSO

Mecanismos bioquímicos e fisiológicos

Aminophylline (Phyllocontin) is a competitive nonselective phosphodiesterase inhibitor with an IC50 of 0.12 mM and also a nonselective adenosine receptor antagonist.

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Tipo de ação

INHIBITOR

Mecanismo de ação

Adenosine receptor antagonist

Nomes e identificadores

• SMILES isoméricas: CN1C2=C(C(=O)N(C1=O)C)NC=N2.CN1C2=C(C(=O)N(C1=O)C)NC=N2.C(CN)N
• WGK Alemanha: 3
• RTECS: XH5600000
• Número UN: 2811
• Peso molecular: 420.43
• Reaxy-Rn: 5784418
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=5784418&ln=

Propriedades químicas e físicas

• Solubilidade: Solubility (25°C) In vitro DMSO: 100 mg/mL Water: Insoluble; Ethanol: 100 mg/mL
• Ponto de fusão (°C): 269-270°C

Referências

1. Chaozhi Ma, Liyuan Zou, Yu Xia, Yijun Tu, Daquan Xue, Yanfang Yang, Dan Liu, Yanwen Liu, Hezhen Wu, Hanxiong Dan, Pengtao You.  (2018)  Extracts of Coleus forskohlii relieves cough and asthma symptoms via modulating inflammation and the extracellular matrix.  JOURNAL OF CELLULAR BIOCHEMISTRY,  120  (6): (9648-9655).  [PMID:30520122] [10.1002/jcb.28243]

2. Xingxing Duan, Bufan Yu, Guangrong Jin, Dengliang Zhang, Jiangshan Chen, Dongge Ma.  (2024)  Modification of mixed-halide quasi-2D perovskites by aminophylline towards efficient and spectrally stable blue light-emitting diodes with low efficiency roll-off.  Journal of Materials Chemistry C,      [PMID:] [10.1039/D4TC04214J]