ANT3310 sodium - ≥99% , CAS No.2410688-61-6

CAS: 2410688-61-6 Cat. No.: A649786 Fórmula: C₆H₈FN₂NaO₅S Peso molecular: 262.19

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Visão geral

ANT3310 sodium is a broad-spectrum covalent Serine β-Lactamase inhibitor, with IC 50 values ranging from 1 nM to 175 nM (a panel of Serine β-Lactamase). ANT3310 sodium potentiates activity of β-lactam antibiotics against Carbapenem-Resistant Enterobacterales (CRE) and Acinetobacter baumannii (CRAB). ANT3310 sodium can be used in the research of bacterial infection.

In Vitro

ANT3310 sodium (Compound 21, 0.006 to 3 000 nM, 10 min) inhibits a series of Serine β-Lactamase (AmpC, CTX-M-15, TEM-1, OXA-48, OXA-23, and KPC-2), with IC <>50 values ranging from 1 nM to 175 nM. ANT3310 sodium shows a low in vitro cytotoxicity (IC <>50 : > 100 μM) in HepG2 cell, cardiotoxicity (inhibition of the hERG potassium ion channel), and genotoxicity (Ames test). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ANT3310 sodium (intravenous injection, 25-100 mg/kg, at 1, 3, 5, and 7 h postinfection) reduces bacterial burdens in murine thigh infection model . ANT3310 sodium (intravenous injection, 1 mg/kg, Male Swiss albino mice) shows a T 1/2 value of 0.64 h, AUC value of 412 ng•h/mL, and Cl value of 40 mL/min/kg (pharmacokinetic assay) . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Murine thigh infection model Dosage: 25, 50, and 100 mg/kg Administration: Intravenous injection, at 1, 3, 5, and 7 h postinfection Result: Reduced bacterial burdens (colony forming units, CFU) in a dose-dependent manner to levels below that of the initial starting inoculum at the highest dose, when treated with the combination of MEM.

Form:Solid

Specifications

Especificações e pureza

≥99%

Mecanismos bioquímicos e fisiológicos

ANT3310 sodium is a broad-spectrum covalent Serine β-Lactamase inhibitor, with IC 50 values ranging from 1 nM to 175 nM (a panel of Serine β-Lactamase). ANT3310 sodium potentiates activity of β-lactam antibiotics against Carbapenem-Resistant Enterobactera

Condições de armazenamento de armazenamento

Store at -20°C

Enviado em

Ice chest + Ice pads

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Tipo de ação

INHIBITOR

Pureza

≥99%

Nomes e identificadores

• Peso molecular: 262.19

Propriedades químicas e físicas

• Solubilidade: DMSO : 250 mg/mL (953.51 mM; Need ultrasonic)