Antipyrine - 10mM in DMSO , Cyclooxygenase-1 inhibitor, CAS No.60-80-0, Cyclooxygenase-1 inhibitor

CAS: 60-80-0 Cat. No.: A408977 Fórmula: C₁₁H₁₂N₂O Peso molecular: 188.23 Beilstein Registry Number: 157775 Número CE: 200-486-6

GRADE & PURITY 10mM in DMSO

Synonyms

Phenazone | 1,5-dimethyl-2-phenyl-1,2-dihydropyrazol-3-one

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

Information

Antipyrine Antipyrine (Phenazone) is an analgesic and antipyretic agent; selective COX-3 inhibitor.
In vitro

Antipyrine is an analgesic and antipyretic.

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinónimos

Phenazone | 1,5-dimethyl-2-phenyl-1,2-dihydropyrazol-3-one

Especificações e pureza

10mM in DMSO

Mecanismos bioquímicos e fisiológicos

Antipyrine (Phenazone) is an analgesic and antipyretic agent; selective COX-3 inhibitor.

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Tipo de ação

INHIBITOR

Mecanismo de ação

Cyclooxygenase-1 inhibitor

Propriedades do produto

• ALogP: 0.4

Nomes e identificadores

• SMILES isoméricas: CC1=CC(=O)N(N1C)C2=CC=CC=C2
• WGK Alemanha: 1
• RTECS: CD2450000
• Peso molecular: 188.23
• Beilstein: 157775
• Reaxy-Rn: 157775
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=157775&ln=

Alvos associados (humanos)

NAPRT Tchem Nicotinate phosphoribosyltransferase (2 Activities)

Discover Target: NAPRT

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propriedades químicas e físicas

• Índice de refração: 1.5697
• Ponto de ebulição (°C): 319°C
• Ponto de fusão (°C): 114°C

Referências

1. Shilong Jiang, Song Cheng, Jiashun Cao, Cailiang Yue, Jianglei Xiong, Cong Jiang, Hongzhan Cai, Jianhua Wu.  (2023)  Monodispersed Co-N3 loaded carbon nitride mediated peroxymonosulfate activation for rapid degradation of trace urea via singlet oxygen.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2023.147526]

2. Yuqiong Gao, Han Ning, Yanyan Rao, Kexuan Li, Chaole Zeng, Naiyun Gao.  (2023)  Efficient elimination of phenazone by an electro-assisted Fe3+-EDDS/PS process at neutral pH: Kinetics, mechanistic insights and toxicity evaluation.  CHEMOSPHERE,      [PMID:37028723] [10.1016/j.chemosphere.2023.138598]

3. Wanbao Wu, Yihong Liang, Deping Li, Yiyang Bo, Dong Wu, Lijie Ci, Mingyu Li, Jiaheng Zhang.  (2022)  A Competitive Solvation of Ternary Eutectic Electrolytes Tailoring the Electrode/Electrolyte Interphase for Lithium Metal Batteries.  ACS Nano,      [PMID:36040142] [10.1021/acsnano.2c05016]

4. Chen Junyang, Xiang Pan, Duro-Castano Aroa, Cai Huawei, Guo Bin, Liu Xiqin, Yu Yifan, Lui Su, Luo Kui, Ke Bowen, Ruiz-Pérez Lorena, Gong Qiyong, Tian Xiaohe, Battaglia Giuseppe.  (2025)  Rapid amyloid-β clearance and cognitive recovery through multivalent modulation of blood–brain barrier transport.  Signal Transduction and Targeted Therapy,  10  (1): (1-12).  [PMID:41052971] [10.1038/s41392-025-02426-1]

5. Fu Zeng, Lian Huang, Ding Han, Renjie Liu, Kongjia Zhang, Yuwen Su, Tong Su, Yarong Lin, Jianbo Xiu.  (2025)  An Improved SHANEL Procedure for Clearing and Staining Brain Tissue from Multiple Species.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  26  (8): (3569).  [PMID:40332069] [10.3390/ijms26083569]

Perguntas frequentes

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 60-80-0, the molecular formula is C11H12N2O, and the molecular weight is 188.23 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.