AP1867-2-(carboxymethoxy) - ≥99% , CAS No.2230613-03-1

CAS: 2230613-03-1 Cat. No.: A648529 Fórmula: C₃₈H₄₇NO₁₁ Peso molecular: 693.78 Número CE: 894-476-4 PubChem CID: 133080821

GRADE & PURITY ≥99%

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

AP1867-2-(carboxymethoxy), the AP1867 (a synthetic FKBP12 F36V -directed ligand) based moiety, binds to CRBN ligand via a linker to form dTAG molecules.

In Vitro

dTAG molecules engage FKBP12 F36V and CRBN. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

Specifications

Especificações e pureza

≥99%

Mecanismos bioquímicos e fisiológicos

AP1867-2-(carboxymethoxy), the AP1867 (a synthetic FKBP12 F36V -directed ligand) based moiety, binds to CRBN ligand via a linker to form dTAG molecules.

Condições de armazenamento de armazenamento

Protected from light,Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Tipo de ação

INHIBITOR

Pureza

≥99%

Nomes e identificadores

• Sorrisos canónicos: CCC(C1=CC(=C(C(=C1)OC)OC)OC)C(=O)N2CCCCC2C(=O)OC(CCC3=CC(=C(C=C3)OC)OC)C4=CC=CC=C4OCC(=O)O
• IUPAC Name: 2-[2-[(1R)-3-(3,4-dimethoxyphenyl)-1-[(2S)-1-[(2S)-2-(3,4,5-trimethoxyphenyl)butanoyl]piperidine-2-carbonyl]oxypropyl]phenoxy]acetic acid
• InChIKey: UYXSZUBFOQLRNQ-BTIIJPOSSA-N
• INCHI: 1S/C38H47NO11/c1-7-26(25-21-33(46-4)36(48-6)34(22-25)47-5)37(42)39-19-11-10-13-28(39)38(43)50-30(27-12-8-9-14-29(27)49-23-35(40)41)17-15-24-16-18-31(44-2)32(20-24)45-3/h8-9,12,14,16,18,20-22,26,28,30H,7,10-11,13,15,17,19,23H2,1-6H3,(H,40,41)/t26-,28-,30+/m0/s1
• PubChem CID: 133080821
• Peso molecular: 693.78

Propriedades químicas e físicas

• Solubilidade: DMSO : 180 mg/mL (259.45 mM; Need ultrasonic)
• Peso molecular: 693.800 g/mol
• XLogP3: 6.300
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 11
• Rotatable Bond Count: 18
• Exact Mass: 693.315 Da
• Monoisotopic Mass: 693.315 Da
• Topological Polar Surface Area: 139.000 Ų
• Heavy Atom Count: 50
• Formal Charge: 0
• Complexity: 1050.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 3
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1