Atomoxetine HCl - 10mM in DMSO , Norepinephrine transporter inhibitor, CAS No.82248-59-7, Norepinephrine transporter inhibitor

CAS: 82248-59-7 Cat. No.: A407994 Molecular Weight: 291.82 EC Number: 629-925-3

GRADE & PURITY 10mM in DMSO

Synonyms

LY 139603 HCl | (R)-N-methyl-3-phenyl-3-(o-tolyloxy)propan-1-amine hydrochloride

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Atomoxetine HCl Atomoxetine (LY 139603) is a selective norepinephrine (NE) transporter inhibitor with K i of 5 nM, with 15- and 290-fold lower affinity for human 5-HT and DA transporters.
In vitro

Atomoxetine is a selective norepinephrine reuptake inhibitor with K_i of 5 nM, compared with 77 and 1451 nM for binding to serotonin and dopamine transporters.

In vivo

In microdialysis studies, atomoxetine increases extracellular (EX) levels of NE in prefrontal cortex (PFC) 3-fold, but does not alter 5-HT_EX levels. Atomoxetine also increases DA_EX concentrations in PFC 3-fold, but does not alter DA_EX in striatum or nucleus accumbens. Atomoxetine increases Fos by 3.7-fold in PFC, but not in the striatum or nucleus accumbens. Atomoxetine selectively inhibits the presynaptic uptake of norepinephrine in adrenergic neurons in animals, and has activity in animal models of depression.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

LY 139603 HCl | (R)-N-methyl-3-phenyl-3-(o-tolyloxy)propan-1-amine hydrochloride

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Atomoxetine (LY 139603) is a selective norepinephrine (NE) transporter inhibitor with K_i of 5 nM, with 15- and 290-fold lower affinity for human 5-HT and DA transporters.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Mechanism of action

Norepinephrine transporter inhibitor

Names and Identifiers

• Isomeric SMILES: CC1=CC=CC=C1O[C@H](CCNC)C2=CC=CC=C2.Cl
• WGK Germany: 1
• Alternate CAS: 83015-26-3
• Molecular Weight: 291.82
• Reaxy-Rn: 6691924
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=6691924&ln=

Chemical and Physical Properties

• Specific Rotation[α]: -42° (C=1,MeOH)
• Melt Point(°C): 167.0 - 171.0 °C

References

1. Jieqing Feng, Qisheng Zhong, Ting Zhou.  (2022)  Online Pressure Change Focusing-Supercritical Fluid Selective Extraction Chromatography for Analyzing Chiral Drugs in Microliter-Scale Plasma Samples.  ANALYTICAL CHEMISTRY,      [PMID:36356211] [10.1021/acs.analchem.2c03892]

2. Yutong You, Xu Wang, Kaiqi Ma, Jiaru Li, Ying Peng, Jiang Zheng.  (2021)  Metabolic Activation of Atomoxetine Mediated by Cytochrome P450 2D6.  CHEMICAL RESEARCH IN TOXICOLOGY,      [PMID:34431675] [10.1021/acs.chemrestox.1c00216]