AZ 628 - Moligand™, ≥98% , Inhibitor of B-Raf proto-oncogene; serine/threonine kinase, CAS No.878739-06-1, Inhibitor of B-Raf proto-oncogene; serine/threonine kinase
AZ 628 - Moligand™, ≥98% , Inhibitor of B-Raf proto-oncogene; serine/threonine kinase, CAS No.878739-06-1, Inhibitor of B-Raf proto-oncogene; serine/threonine kinase
GRADE & PURITYMoligand™?Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.≥98%
Synonyms
NCGC00250380-03 | J-510421 | 3-(2-Cyanopropan-2-yl)-N-(4-methyl-3-((3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino)phenyl)benzamide | 3-(2-Cyanopropan-2-Yl)-N-{4-Methyl-3-[(3-Methyl-4-Oxo-3,4-Dihydroquinazolin-6-Yl)amino]phenyl}benzamide | 3,4-dichloro p
Moligand™, ≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Armazenar a -20°C Ships Arca de gelo + almofadas de gelo Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Specifications
Sinónimos
NCGC00250380-03 | J-510421 | 3-(2-Cyanopropan-2-yl)-N-(4-methyl-3-((3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino)phenyl)benzamide | 3-(2-Cyanopropan-2-Yl)-N-{4-Methyl-3-[(3-Methyl-4-Oxo-3,4-Dihydroquinazolin-6-Yl)amino]phenyl}benzamide | 3,4-dichloro p
Especificações e pureza
Moligand™, ≥98%
Mecanismos bioquímicos e fisiológicos
O AZ628 é um potente inibidor da Raf quinase com valores IC50 de 105 nM para a Raf-B de tipo selvagem, 34 nM para a Raf-B V600E e 29 nM para a Raf-1 de tipo selvagem. O AZ628 é um inibidor do tipo II que se liga à configuração cataliticamente inativa Asp-
Condições de armazenamento de armazenamento
Armazenar a -20°C
Enviado em
Arca de gelo + almofadas de gelo
Grau
Moligand™
Tipo de ação
INHIBITOR
Mecanismo de ação
Inhibitor of B-Raf proto-oncogene; serine/threonine kinase
Nota
Sempre que possível, deve preparar e utilizar as soluções no mesmo dia. No entanto, se precisar de preparar soluções de reserva com antecedência, recomendamos que guarde a solução como alíquotas em frascos hermeticamente fechados a -20°C. Em geral, estas podem ser utilizadas durante um mês. Antes de utilizar, e antes de abrir o frasco, recomendamos que deixe o produto equilibrar-se à temperatura ambiente durante pelo menos 1 hora. Tóxico, consulte o SDS para mais informações. Precisa de mais conselhos sobre solubilidade, utilização e manuseamento? Visite a nossa página de perguntas frequentes (FAQ) para obter mais informações.
This compound belongs to the class of organic compounds known as benzanilides. These are aromatic compounds containing an anilide group in which the carboxamide group is substituted with a benzene ring. They have the general structure RNC(=O)R', where R,R'= benzene.
External Descriptors
Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
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