AZD-9574 - ≥99% , CAS No.2756333-39-6

CAS: 2756333-39-6 Cat. No.: A649158 Fórmula: C₂₁H₂₂F₂N₆O₂ Peso molecular: 428.44 PubChem CID: 162524593

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Visão geral

AZD-9574 is a potent and brain penetrant PARP1 inhibitor and shows >8000-fold selectivity for PARP1 compared to PARP2/3/5a/6. AZD-9574 acts by selectively inhibiting and trapping PARP1 at the sites of SSBs. AZD-9574 is an anti-cancer agent and can be used for HRD + breast cancer and advanced solid malignancies research

In Vitro

AZD-9574 inhibits PARP1 enzymatic activity with IC 50 s range between 0.3-2 nM in all tested cell lines irrespective of the homologous recombination repair (HRR) status. In isogenic cell lines pairs confirms higher potency and selectivity towards HRR-deficient (HRD + ) models (DLD1 BRCA2 -/- ; SKOV-3 BRCA2 -/- and SKOV-3 PALB2 -/- ). The IC 50 in BRCA2 -/- DLD1 cells is 1.38 nM compared to IC 50 >40 µM BRCA2 wt cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AZD-9574 (3 mg/kg) shows sustained tumour growth suppression resulting in a significantly extended survival of tumour-bearing mice, in intracranial xenograft model of breast cancer brain metastases . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:PPAR

Specifications

Especificações e pureza

≥99%

Mecanismos bioquímicos e fisiológicos

AZD-9574 is a potent and brain penetrant PARP1 inhibitor and shows >8000-fold selectivity for PARP1 compared to PARP2/3/5a/6. AZD-9574 acts by selectively inhibiting and trapping PARP1 at the sites of SSBs. AZD-9574 is an anti-cancer agent and can be used

Condições de armazenamento de armazenamento

Store at -20°C

Enviado em

Ice chest + Ice pads

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Tipo de ação

INHIBITOR

Pureza

≥99%

Nomes e identificadores

• SMILES isoméricas: CC1=NC2=C(C(=C(C=C2)CN3CCN(CC3)C4=C(N=C(C=C4)C(=O)NC)F)F)NC1=O
• PubChem CID: 162524593
• Peso molecular: 428.44

Propriedades químicas e físicas

• Solubilidade: DMSO : 22.22 mg/mL (51.86 mM; ultrasonic and adjust pH to 4 with HCl) DMSO : 8.33 mg/mL (19.44 mM; ultrasonic and warming and heat to 60°C)
• Peso molecular: 428.400 g/mol
• XLogP3: 1.200
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 4
• Exact Mass: 428.177 Da
• Monoisotopic Mass: 428.177 Da
• Topological Polar Surface Area: 89.900 Ų
• Heavy Atom Count: 31
• Formal Charge: 0
• Complexity: 714.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1