B-Raf IN 10 - 10mM in DMSO , CAS No.1425485-87-5

CAS: 1425485-87-5 Cat. No.: B655197 Molecular Weight: 494.49

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

B-Raf IN 10 (Compound C09) is a BRAF inhibitor with an IC 50 between 50 and 100 nM. B-Raf IN 10 shows antitumor activity

In Vitro

B-Raf IN 10 (Compound C09) (1 μM) shows more than 89% inhibition against BRAF and BRAF V600E. B-Raf IN 10 shows an IC 50 between 50 and 100 nM against BRAF, less than 50 nM against BRAF V600E. B-Raf IN 10 (72 h) inhibits A375 and SK-MEL-28 cells growth but not CHL-1 and SK-MEL-31 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: A375, SK-MEL-28, SK-MEL-31 and CHL-1 Concentration: Incubation Time: 72 h Result: Showed inhibition with IC 50 s less than 500 nM against A375 and SK-MEL-28 cells, and showed no inhibition against CHL-1 and SK-MEL-31.

IC50& Target:BRAF-V600E < 50 nM (IC 50 ) Braf 50-100 nM (IC 50 )

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

B-Raf IN 10 (Compound C09) is a BRAF inhibitor with an IC 50 between 50 and 100 nM. B-Raf IN 10 shows antitumor activity.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Names and Identifiers

• Molecular Weight: 494.49