Beclomethasone dipropionate - Moligand™, 10mM in DMSO , Glucocorticoid receptor agonist, CAS No.5534-09-8, Glucocorticoid receptor agonist

CAS: 5534-09-8 Cat. No.: B409241 Fórmula: C₂₈H₃₇ClO₇ Peso molecular: 521.04 Número CE: 226-886-0

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

Beclometasone dipropionate | 9α-Chloro-16β-methylprednisolone 17,21-dipropionate

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

Information

Beclomethasone dipropionate Beclomethasone dipropionate is a potent glucocorticoid steroid used for the treatment of rhinitis and sinusitis.
In vitro

Beclomethasone dipropionate (BDP) is an anti-inflammatory corticosteroid available for the treatment of asthma and allergic rhinitis (AR). BDP is previously developed as aqueous nasal formulations for the treatment of AR. BDP is also available in dry nasal aerosol formulations as chlorofluoro carbon (CFC) metered-dose inhaler nasal sprays, but CFC-containing formulations have been withdrawn from the market and currently are not available.BDP hydrofluoroalkane (HFA) inhalation aerosol currently is available for patient use and indicated for the maintenance treatment of asthma as prophylactic therapy in patients 5 years of age and older.BDP HFA nasal aerosol, an intranasal aerosol formulation, has been developed recently for the treatment of AR.

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinónimos

Beclometasone dipropionate | 9α-Chloro-16β-methylprednisolone 17,21-dipropionate

Especificações e pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos e fisiológicos

Beclomethasone dipropionate is a potent glucocorticoid steroid used for the treatment of rhinitis and sinusitis.

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Grau

Moligand™

Tipo de ação

AGONIST

Mecanismo de ação

Glucocorticoid receptor agonist

Propriedades do produto

• ALogP: 3

Nomes e identificadores

• SMILES isoméricas: CCC(=O)OCC(=O)[C@]1([C@H](C[C@@H]2[C@@]1(C[C@@H]([C@]3([C@H]2CCC4=CC(=O)C=C[C@@]43C)Cl)O)C)C)OC(=O)CC
• RTECS: TU3805000
• CAS alternativo: 66734-13-2
• Peso molecular: 521.04
• Reaxy-Rn: 24731460
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24731460&ln=

Alvos associados (humanos)

ADGRG3 Tchem Adhesion G protein-coupled receptor G3 (1 Activities)

Discover Target: ADGRG3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propriedades químicas e físicas

• Ponto de fusão (°C): 208-210°C

Referências

1. Youfang Huang, Yanyun Li, Qing Luo, Xiaojia Huang.  (2020)  One-step preparation of functional groups-rich graphene oxide and carbon nanotubes nanocomposite for efficient magnetic solid phase extraction of glucocorticoids in environmental waters.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2020.126785]