Bergenin - 10mM in DMSO , CAS No.477-90-7

CAS: 477-90-7 Cat. No.: B408735 Fórmula: C₁₄H₁₆O₉ Peso molecular: 328.28 Número CE: 803-760-9

GRADE & PURITY 10mM in DMSO

Synonyms

Cuscutin | Pyrano[3,2-c][2]benzopyran-6(2H)-one, 3,4,4a,10b-tetrahydro-3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxy-, (2R,3S,4S,4aR,10bS)-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

Information

Bergenin (Cuscutin) is trihydroxybenzoic acid glycoside and the C-glycoside of 4-O-methyl gallic acid.
In vitro

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinónimos

Cuscutin | Pyrano[3,2-c][2]benzopyran-6(2H)-one, 3,4,4a,10b-tetrahydro-3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxy-, (2R,3S,4S,4aR,10bS)-

Especificações e pureza

10mM in DMSO

Mecanismos bioquímicos e fisiológicos

Bergenin (Cuscutin) is trihydroxybenzoic acid glycoside and the C-glycoside of 4-O-methyl gallic acid.

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Nomes e identificadores

• SMILES isoméricas: COC1=C(C=C2C(=C1O)[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)OC2=O)O
• Peso molecular: 328.28
• Reaxy-Rn: 1354737
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1354737&ln=

Alvos associados (humanos)

IL6 Tclin Interleukin-6 (0 Activities)

Discover Target: IL6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propriedades químicas e físicas

• Ponto de fusão (°C): 238°C

Referências

1. Huang Dan, Sun Chaoqun, Chen Min, Bai Shuyou, Zhao Xuanna, Wang Weiming, Geng Kang, Huang Wenbo, Zhao Tingting, Wu Bin, Zhang Guilin, Wu Dong, Xu Youhua.  (2022)  Bergenin ameliorates airway inflammation and remodeling in asthma by activating SIRT1 in macrophages to regulate the NF-κB pathway.  Frontiers in Pharmacology,      [PMID:36313381] [10.3389/fphar.2022.994878]

2. Yinggui Zhu, Lili Zou, Qin Dong, Derong Jiang.  (2015)  Determination of bergenin based on the electrochemiluminescence quenching of tris(2,2′-bipyridine)-ruthenium(II).  LUMINESCENCE,  30  (8): (1269-1273).  [PMID:25808319] [10.1002/bio.2891]

3. Min Chen, Cuifen Chen, Yun Gao, Dongming Li, Dan Huang, Ziyu Chen, Xuanna Zhao, Qiu Huang, Dong Wu, Tianwen Lai, Guomei Su, Bin Wu, Beixian Zhou.  (2020)  Bergenin-activated SIRT1 inhibits TNF-α-induced proinflammatory response by blocking the NF-κB signaling pathway.  PULMONARY PHARMACOLOGY & THERAPEUTICS,      [PMID:32615160] [10.1016/j.pupt.2020.101921]

4. Yanrong Zhu, Lichen Yao, Yilei Guo, Jing Zhang, Yufeng Xia, Zhifeng Wei, Yue Dai.  (2024)  Bergenin attenuates triptolide-caused premature ovarian failure in mice based on the antioxidant activity.  REPRODUCTIVE TOXICOLOGY,      [PMID:38735593] [10.1016/j.reprotox.2024.108608]

5. Yu-Zhen Zhang, Yi-Le Li, Zhi Jin, Mao-Fang He, Yi-Mei Tang, Jian Zhang, Bo Zhang.  (2024)  Fabrication of molecularly imprinted polymers based on magnetic covalent organic framework for highly selective and sensitive analysis of genistein in F. Philippinensis.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2024.110013]

6. Yao Sun, Shihao Cai, Hongting Liu, Conglu Zhao, Xiang Xu, Xiaoting Wang, Jia Zhang, Chaoyue Zheng, Keran Li, Shouchun Peng, Honggang Zhou, Aiguo Xu, Xiaoting Gu, Xiaoyu Ai, Cheng Yang.  (2025)  Bergenin and vitexin delivery platform using mouse lung fibroblasts-derived exosomes for bleomycin-induced pulmonary fibrosis therapy.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,      [PMID:40456424] [10.1016/j.ijpharm.2025.125750]