BLT-1 - ≥98% , CAS No.321673-30-7

CAS: 321673-30-7 Cat. No.: B412587 Fórmula: C₁₂H₂₃N₃S Peso molecular: 241.4

GRAU & PUREZA ≥98%

Synonyms

33M20 | Probes2_000409 | DTXSID80430563 | Probes1_000008 | Probes1_000093 | Probes2_000390 | BLT-1 | E74752 | EN300-68381 | (2Z)-2-(2-hexylcyclopentylidene)hydrazinecarbothioamide | EX-A4880 | [(2-hexylcyclopentylidene)amino]thiourea | Z275117012 | SCHEMB

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Visão geral

BLT-1 (Block lipid transport-1) has been used as an inhibitor of the SR-BI (scavenger receptor, class B, type I) mediated lipid transfer to determine if miR-223-3p export from polymorphonuclear neutrophils (PMNs) to high-density lipoproteins (HDLs) is dependent on SR-BI-mediated lipid flux. It has also been used as a SR-BI inhibitor to study the effect of HDL on osteocalcin (OCN) expression in monocyte cell lines through SR-B1. BLT-1 may be used to study cell signaling pathways that have role in cholesterol influx and efflux.

Especificações

Sinónimos

33M20 | Probes2_000409 | DTXSID80430563 | Probes1_000008 | Probes1_000093 | Probes2_000390 | BLT-1 | E74752 | EN300-68381 | (2Z)-2-(2-hexylcyclopentylidene)hydrazinecarbothioamide | EX-A4880 | [(2-hexylcyclopentylidene)amino]thiourea | Z275117012 | SCHEMB

Especificações e pureza

≥98%

Mecanismos bioquímicos e fisiológicos

BLT-1 is an inhibitor of HDL receptor SR-BI. BLT-1 is primarily used for phosphorylation and dephosphorylation applications.Block lipid transport-1 (BLT-1) is a specific inhibitor of the SR-BI (Scavenger receptor, class B, type I) mediated lipid transfer.

Condições de armazenamento de armazenamento

Store at -20°C

Enviado em

Ice chest + Ice pads

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Tipo de ação

INHIBITOR

Pureza

≥98%

Nomes e identificadores

Pubchem Sid

528763451

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/528763451

Sorrisos canónicos

CCCCCCC1CCCC1=NNC(=S)N

IUPAC Name

[(E)-(2-hexylcyclopentylidene)amino]thiourea

InChIKey

OWGUSBISUVLUJF-SDNWHVSQSA-N

INCHI

1S/C12H23N3S/c1-2-3-4-5-7-10-8-6-9-11(10)14-15-12(13)16/h10H,2-9H2,1H3,(H3,13,15,16)/b14-11+

SMILES isoméricas

CCCCCCC\1CCC/C1=N\NC(=S)N

WGK Alemanha

3

Peso molecular

241.4

Reaxy-Rn

11250336

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=11250336&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic nitrogen compounds
    • Classe Organonitrogen compounds
      • Subclass Hydrazines and derivatives
        • Level5 Thiosemicarbazides
          • Level6 Thiosemicarbazones

• Kingdom: Organic compounds
• Superclass: Organic nitrogen compounds
• Classe: Organonitrogen compounds
• Subclass: Hydrazines and derivatives
• Intermediate Tree Nodes: Thiosemicarbazides
• Direct Parent: Thiosemicarbazones
• Alternative Parents: Organosulfur compounds Hydrocarbon derivatives
• Molecular Framework: Aliphatic homomonocyclic compounds
• Substituents: Thiosemicarbazone - Hydrocarbon derivative - Organosulfur compound - Aliphatic homomonocyclic compound
• Descrição: This compound belongs to the class of organic compounds known as thiosemicarbazones. These are compounds containing the thiosemicarbazone functional group obtained by replacing the carbonyl group by a thiocarbonyl group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Mecanismos de ação

Propriedades químicas e físicas

• Solubilidade: DMSO: ≥13 mg/mL
• Peso molecular: 241.400 g/mol
• XLogP3: 3.300
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 6
• Exact Mass: 241.161 Da
• Monoisotopic Mass: 241.161 Da
• Topological Polar Surface Area: 82.500 Ų
• Heavy Atom Count: 16
• Formal Charge: 0
• Complexity: 251.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 1
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 1
• Covalently-Bonded Unit Count: 1