BML-190 - 10mM in DMSO , CAS No.2854-32-2

CAS: 2854-32-2 Cat. No.: B408769 Fórmula: C₂₃H₂₃ClN₂O₄ Peso molecular: 426.89

GRAU & PUREZA 10mM in DMSO

Synonyms

IMMA | Ethanone, 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-1-(4-morpholinyl)-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

Information

BML-190 (IMMA) is a selectivecannabinoid CB2 receptorinverse agonist withKiof 435 nM, with 50-fold selectivity over CB1 receptor.
In vitro

BML-190 has 50-fold selectivity for CB2 receptors over CB1 receptors. In HEK-293 cells stably expressing the human CB2 receptor, BML-190 potentiates the forskolin-stimulated accumulation of cAMP. BML-190 reduces the basal levels of inositol phosphate production in cells expressing the CB2 receptor. 10 μM of BML-190 decreases inositol phosphates accumulation by 38%. BML-190 is an aminoalkylindole. BML-190 is found to yield at least 15 metabolic products. BML-190 diminishes LPS-induced NO and IL-6 production in a concentration-dependent manner. BML-190 also inhibits LPS-induced PGE2 production and COX-2 induction.

In vivo

Cell Data

cell lines：

Concentrations：0 μM -100 μM

Incubation Time：20 hours–24 hours

Powder Purity:≥99%

Especificações

Sinónimos

IMMA | Ethanone, 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-1-(4-morpholinyl)-

Especificações e pureza

10mM in DMSO

Mecanismos bioquímicos e fisiológicos

BML-190 (IMMA) is a selective cannabinoid CB2 receptor inverse agonist with K_i of 435 nM, with 50-fold selectivity over CB1 receptor.

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Tipo de ação

AGONIST

Nomes e identificadores

SMILES isoméricas

CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)N4CCOCC4

Peso molecular

426.89

Reaxy-Rn

1230853

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1230853&ln=

Propriedades químicas e físicas

• Solubilidade: Solubility (25°C) In vitro DMSO: 69 mg/mL (199.15 mM); Ethanol: 9 mg/mL warmed with 50ºC Water: bath (25.97 mM); Water: Insoluble