BMS-587101 - 10mM in DMSO , CAS No.509083-77-6

CAS: 509083-77-6 Cat. No.: B655243 Fórmula: C₂₆H₂₀Cl₂N₄O₄S Peso molecular: 555.43 PubChem CID: 11635371

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

BMS-587101 is a potent and orally active antagonist of leukocyte function associated antigen-1 (LFA-1). BMS-587101 has anti-inflammatory effects and can be used for rheumatoid arthritis research.

In Vitro

BMS-587101 is a moderately potent inhibitor of LFA-1-mediated T-cell proliferation, with an IC 50 of 20 nM in human HUVEC cells. BMS-587101 inhibits LFA-1-mediated adhesion of T cells to endothelial cells, T cell proliferation, and Th1 cytokine production . In mouse splenocytes and a mouse ICAM-1 expressing cell lines, bEND, BMS-587101 shows inhibitory activities, with an IC 50 of 150 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In the mouse ovalbumin-induced lung inflammation model, BMS-587101 (0.1 mg/kg, 1.0 mg/kg, and 10 mg/kg; po.; twice a day) treatment significantly inhibits eosinophil accumulation . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Specifications

Especificações e pureza

10mM in DMSO

Mecanismos bioquímicos e fisiológicos

BMS-587101 is a potent and orally active antagonist of leukocyte function associated antigen-1 (LFA-1) . BMS-587101 has anti-inflammatory effects and can be used for rheumatoid arthritis research.

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Tipo de ação

ANTAGONIST

Nomes e identificadores

• SMILES isoméricas: CN1C(=O)N(C(=O)[C@]12CN(C[C@H]2C3=CC=C(C=C3)C#N)CC4=CC(=CS4)C(=O)O)C5=CC(=CC(=C5)Cl)Cl
• PubChem CID: 11635371
• Peso molecular: 555.43