BMS CCR2 22 - ≥98%(HPLC) , CAS No.445479-97-0

CAS: 445479-97-0 Cat. No.: B287471 Fórmula: C₂₈H₃₄F₃N₅O₄S Peso molecular: 593.66

GRADE & PURITY ≥98%(HPLC)

Synonyms

IBPXYDUJQWENPM-PKTZIBPZSA-N | N-[2-({(1R,2S)-2-[4-(Methylsulfanyl)benzamido]cyclohexyl}amino)-2-oxoethyl]-2-{[(propan-2-yl)carbamoyl]amino}-5-(trifluoromethyl)benzamide | BMS22 | 2-(3-Isopropylureido)-N-(2-((cis-2-(4-(methylthio)benzamido)cyclohexyl)amino

Storage

Store at 2-8°C

Shipped In

Wet ice

Specifications

Sinónimos

IBPXYDUJQWENPM-PKTZIBPZSA-N | N-[2-({(1R,2S)-2-[4-(Methylsulfanyl)benzamido]cyclohexyl}amino)-2-oxoethyl]-2-{[(propan-2-yl)carbamoyl]amino}-5-(trifluoromethyl)benzamide | BMS22 | 2-(3-Isopropylureido)-N-(2-((cis-2-(4-(methylthio)benzamido)cyclohexyl)amino

Especificações e pureza

≥98%(HPLC)

Mecanismos bioquímicos e fisiológicos

High affinity CCR2 chemokine receptor antagonist (IC50= 5.1 nM). Displays potent functional antagonism, IC50values are 1 and 18 nM for chemotaxis and antagonism of calcium flux respectively. Selective over CCR3.

Condições de armazenamento de armazenamento

Store at 2-8°C

Enviado em

Wet ice

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Tipo de ação

ANTAGONIST

Pureza

≥98%(HPLC)

Nomes e identificadores

• Sorrisos canónicos: CC(C)NC(=O)NC1=C(C=C(C=C1)C(F)(F)F)C(=O)NCC(=O)NC2CCCCC2NC(=O)C3=CC=C(C=C3)SC
• IUPAC Name: N-[2-[[(1R,2S)-2-[(4-methylsulfanylbenzoyl)amino]cyclohexyl]amino]-2-oxoethyl]-2-(propan-2-ylcarbamoylamino)-5-(trifluoromethyl)benzamide
• InChIKey: IBPXYDUJQWENPM-PKTZIBPZSA-N
• INCHI: 1S/C28H34F3N5O4S/c1-16(2)33-27(40)36-21-13-10-18(28(29,30)31)14-20(21)26(39)32-15-24(37)34-22-6-4-5-7-23(22)35-25(38)17-8-11-19(41-3)12-9-17/h8-14,16,22-23H,4-7,15H2,1-3H3,(H,32,39)(H,34,37)(H,35,38)(H2,33,36,40)/t22-,23+/m1/s1
• SMILES isoméricas: CC(C)NC(=O)NC1=C(C=C(C=C1)C(F)(F)F)C(=O)NCC(=O)N[C@@H]2CCCC[C@@H]2NC(=O)C3=CC=C(C=C3)SC
• Peso molecular: 593.66
• Reaxy-Rn: 14121200
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=14121200&ln=

Alvos associados (humanos)

CCR2 Tchem C-C chemokine receptor type 2 (0 Activities)

Discover Target: CCR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propriedades químicas e físicas

• Solubilidade: Solvent:DMSO, Max Conc. mg/mL: 59.37, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 5.94, Max Conc. mM: 10