Bocidelpar - Moligand™,≥98% , CAS No.2095128-20-2

CAS: 2095128-20-2 Cat. No.: B648929 Fórmula: C₂₅H₂₇F₃N₂O₃ Peso molecular: 460.49 PubChem CID: 126752383

GRAU & PUREZA Moligand™, ≥98%

Synonyms

(R)-3-Methyl-6-(2-((5-methyl-2-(4-(trifluoromethyl)phenyl)-1H-imidazol-1-yl)methyl)phenoxy)hexanoic acid | ASP0367 | MA-0211 | SP-0367

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Visão geral

Bocidelpar is a selective PPARδ modulator. Bocidelpar activates the PPARδ downstream signaling pathway, upregulates the expression of target genes such as ABCA1 and ACAA2. Bocidelpar then promotes fatty acid oxidation (FAO) and mitochondrial biogenesis, and improves mitochondrial dysfunction. Bocidelpar can improve mitochondrial biogenesis and function in muscle cells. Bocidelpar is mainly used in the study of mitochondrial dysfunction diseases such as primary mitochondrial myopathy (PMM) and Duchenne muscular dystrophy (DMD).

Especificações

Sinónimos

(R)-3-Methyl-6-(2-((5-methyl-2-(4-(trifluoromethyl)phenyl)-1H-imidazol-1-yl)methyl)phenoxy)hexanoic acid | ASP0367 | MA-0211 | SP-0367

Especificações e pureza

Moligand™,≥98%

Mecanismos bioquímicos e fisiológicos

Bocidelpar is a modulator of peroxisome proliferator-activated receptor delta ( PPAR-δ ). Bocidelpar improves mitochondrial biogenesis and function in Duchenne Muscular Dystrophy (DMD) muscle cells (extracted from patent WO2017062468A1, compound 2b).

Condições de armazenamento de armazenamento

Store at -20°C

Enviado em

Ice chest + Ice pads

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Grau

Moligand™

Tipo de ação

MODULATOR

Pureza

≥98%

Nomes e identificadores

SMILES isoméricas

CC1=CN=C(N1CC2=CC=CC=C2OCCC[C@@H](C)CC(=O)O)C3=CC=C(C=C3)C(F)(F)F

PubChem CID

126752383

Peso molecular

460.49

Propriedades químicas e físicas

• Solubilidade: DMSO : 250 mg/mL (542.90 mM; Need ultrasonic)
• Peso molecular: 460.500 g/mol
• XLogP3: 5.500
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 10
• Exact Mass: 460.197 Da
• Monoisotopic Mass: 460.197 Da
• Topological Polar Surface Area: 64.400 Ų
• Heavy Atom Count: 33
• Formal Charge: 0
• Complexity: 610.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1