BSH-IN-1 - ≥99% , CAS No.2553217-91-5

CAS: 2553217-91-5 Cat. No.: B651381 Fórmula: C₂₅H₄₁FO₃ Peso molecular: 408.59 PubChem CID: 145713829

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Visão geral

BSH-IN-1 is a potent and covalent inhibitor of gut bacterial recombinant bile salt hydrolases ( BSH s) with IC 50 s of 108 nM and 427 nM for B. longum BSH (Gram positive) and B. theta BSH (Gram negative), respectively.

In Vitro

BSH-IN-1 (Compound 7) also inhibits BSH activity in growing cultures of Gram-negative ( B. theta VPI-5482, Bacteroides fragilis ATCC 25285, and Bacteroides vulgatus ATCC 8482) and Gram-positive ( Lactobacillus plantarum WCFS1, C. perfringens ATCC 13124, and Bifidobacterium adolescentis L2-32) bacteria. BSH-IN-1 (Compound 7) also is a potent BSH inhibitor in growing bacterial cultures with IC 50 s of 237 nM and 1070 nM for B. adolescentis (Gram positive) and B. theta (Gram negative), respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

BSH-IN-1 (Compound 7; 10 mg/kg; a single dose; gavage) inhibits BSH activity in C57BL/6 mice and can be gut-restricted . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: C57BL/6 mice Dosage: 10 mg/kg Administration: Single gavage Result: Inhibited gut bacterial BSH activity and modulated the bile acid pool in vivo while not significantly affected the gut bacterial community.

Form:Solid

Specifications

Especificações e pureza

≥99%

Mecanismos bioquímicos e fisiológicos

BSH-IN-1 is a potent and covalent inhibitor of gut bacterial recombinant bile salt hydrolases ( BSH s) with IC 50 s of 108 nM and 427 nM for B. longum BSH (Gram positive) and B. theta BSH (Gram negative), respectively.

Condições de armazenamento de armazenamento

Store at -20°C

Enviado em

Ice chest + Ice pads

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Tipo de ação

INHIBITOR

Pureza

≥99%

Nomes e identificadores

Sorrisos canónicos

CC(CCC(=O)CF)C1CCC2C1(CCC3C2C(CC4C3(CCC(C4)O)C)O)C

IUPAC Name

(5R)-5-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-1-fluorohexan-2-one

InChIKey

XDVGNIBMZHDZLL-GDQMVUAZSA-N

INCHI

1S/C25H41FO3/c1-15(4-5-18(28)14-26)19-6-7-20-23-21(9-11-25(19,20)3)24(2)10-8-17(27)12-16(24)13-22(23)29/h15-17,19-23,27,29H,4-14H2,1-3H3/t15-,16+,17-,19-,20+,21+,22-,23+,24+,25-/m1/s1

PubChem CID

145713829

Peso molecular

408.59

Propriedades químicas e físicas

• Solubilidade: DMSO : 25 mg/mL (61.19 mM; ultrasonic and warming and heat to 80°C)