CAA0225 - Moligand™, ≥95% , Inhibitor of cathepsin L, CAS No.50909779, Inhibitor of cathepsin L

CAS: 50909779 Cat. No.: C385710 Fórmula: C₂₈H₂₉N₃O₅ Peso molecular: 487.55

GRADE & PURITY Moligand™, ≥95%

Synonyms

Cathepsin L Inhibitor

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Visão geral

CAA0225 is an epoxysuccinyl peptide and highly selective rat liver cathepsin L inhibitor (IC|50|= 1.9 nM), while exhibiting little to no effect on rat liver cathepsin B at concentrations higher than 1000-5000 nM,|in vitro|. During autophagy, it has been shown through immunoblotting that CAA0225 (10 µg/ml) effectively inhibits the degradation of LC3-II and GABARAP compared to control, in nutrient-deprived HeLa and Huh-7 cells.
CAA0225is a cathepsin L inhibitor

Specifications

Sinónimos

Cathepsin L Inhibitor

Especificações e pureza

Moligand™, ≥95%

Condições de armazenamento de armazenamento

Store at -20°C

Enviado em

Ice chest + Ice pads

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Grau

Moligand™

Tipo de ação

INHIBITOR

Mecanismo de ação

Inhibitor of cathepsin L

Pureza

≥95%

Nomes e identificadores

• Sorrisos canónicos: C1=CC=C(C=C1)C[C@@H](C(=O)NCC2=CC=CC=C2)NC(=O)[C@@H]3[C@H](O3)C(=O)NCCC4=CC=C(C=C4)O
• SMILES isoméricas: C1=CC=C(C=C1)C[C@@H](C(=O)NCC2=CC=CC=C2)NC(=O)[C@@H]3[C@H](O3)C(=O)NCCC4=CC=C(C=C4)O
• Peso molecular: 487.55
• Reaxy-Rn: 24232149
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24232149&ln=

Alvos associados (humanos)

CTSL Tclin Cathepsin L1 (0 Activities)

Discover Target: CTSL

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)