Calcein, AM - for fluorescence analysis, ≥96%(HPLC) , CAS No.148504-34-1

Name: Calcein, AM - for fluorescence analysis, ≥96%(HPLC) , CAS No.148504-34-1
Brand: Aladdin Scientific
SKU: C131116
Availability: InStock

CAS: 148504-34-1 Cat. No.: C131116 Fórmula: C₄₆H₄₆N₂O₂₃ Peso molecular: 994.87 Número CE: 200-664-3

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Calcein, AM - for fluorescence analysis, ≥96%(HPLC) CAS No(148504-34-1) by Aladdin Scientific

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Disponível para encomenda

GRAU & PUREZA for Fluorescence analysis ? ≥96%(HPLC)

Synonyms

acetoxymethyl 2-[[2-(acetoxymethoxy)-2-oxo-ethyl]-[[3',6'-diacetoxy-7'-[[bis[2-(acetoxymethoxy)-2-oxo-ethyl]amino]methyl]-3-oxo-spiro[isobenzofuran-1,9'-xanthene]-2'-yl]methyl]amino]acetate|Tetrakis(acetoxymethyl) 2,2',2'',2'''-(((3',6'-diacetoxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-2',7'-diyl)bis(methylene))bis(azanetriyl))tetraacetate|[({[3',6'-bis(acetyloxy)-3-oxo-3H-spiro[[2]benzofuran-1,9'-xanthene]-2',7'-diyl]bis(methylene)nitrilo}bis[(1-oxoethane-2,1-diyl)oxy]methylene)] tetraacetate|Calcein-AM|Glycine,N'-[[3',6'-bis(acetyloxy)-3-oxospiro[isobenzo furan-1(3H),9'-[9H]xanthene]-2'7'-diyl]bis(methylene)] bis[N-[2-[(acetyloxy)methoxy]-2-oxoethyl]-, bis[(acetyloxy)methyl] ester|Calcein AM|tetrakis[(acetyloxy)methyl] 2,2',2'',2'''-{[3',6'-bis(acetyloxy)-3-oxo-3H-spiro[[2]benzofuran-1,9'-xanthene]-2',7'-diyl]bis(methanediylnitrilo)}tetraacetate|Glycine, N,N'-((3',6'-bis(acetyloxy)-3-oxospiro(isobenzofuran-1(3H),9'-(9H)xanthene)-2',7'-diyl)bis(methylene))bis(N-(2-((acetyloxy)methoxy)-2-oxoethyl)-, bis((acetyloxy)methyl) ester|Glycine, N,N'-[[3',6'-bis(acetyloxy)-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthene]-2',7'-diyl]bis(methylene)]bis[N-[2-[(acetyloxy)methoxy]-2-oxoethyl]-, 1,1'-bis[(acetyloxy)methyl] ester|acetyloxymethyl 2-[[2-(acetyloxymethoxy)-2-oxidanylidene-ethyl]-[[3',6'-diacetyloxy-7'-[[bis[2-(acetyloxymethoxy)-2-oxidanylidene-ethyl]amino]methyl]-3-oxidanylidene-spiro[2-benzofuran-1,9'-xanthene]-2'-yl]methyl]amino]ethanoate|N,N'-[[3',6'-Bis(acetyloxy)-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthene]-2',7'-diyl]bis(methylene)]bis[N-[2-[(acetyloxy)methoxy]-2-oxoethyl]glycine 1,1'-Bis[(acetyloxy)methyl] Ester|4',5'-Bis(N,N-bis(carboxymethyl)aminomethyl)fluorescein acetoxymethyl ester|2-[[2-(acetyloxymethoxy)-2-oxoethyl]-[[3',6'-diacetyloxy-7'-[[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]methyl]-3-oxo-2'-spiro[isobenzofuran-1,9'-xanthene]yl]methyl]amino]acetic acid acetyloxymethyl ester|acetyloxymethyl 2-[[2-(acetyloxymethoxy)-2-oxoethyl]-[[3',6'-diacetyloxy-7'-[[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]methyl]-3-oxospiro[2-benzofuran-1,9'-xanthene]-2'-yl]methyl]amino]acetate

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Folha de especificações

Visão geral Especificações Nomes e identificadores Dados avançados Taxonomic Classification Estrutura 3D Alvos associados (humanos) Mecanismos de ação Certificados（CoA,COO,BSE/TSE e Mapa de Análise) Propriedades químicas e físicas FAQs e artigos Citations of This Product Calculadoras de soluções Revisões

Visão geral

Calcein-AM is a hydrophobic non-fluorescent probe that can permeate the plasma membrane and can be hydrolyzed to Calcein , which is an extremely fluorescent and negatively charged molecule. The probe can be used to stain living cells and has been observed to fluoresce bright green in cytoplasmic Schwann cells. Calcein-AM has been reported to be a neutral substrate for Mdr (P-glycoprotein (Pgp) and multidrug resistance protein (MRP)) and has been used in flow cytometry studies to analyze the function of P-gp and MRP. Studies suggest that Calcein-AM can be used to detect MDR mediated resistance and to be transported by PGP from the plasma membrane. Mitochondrial permeability research has utilized Calcein as a cytosolic fluorophore. Has been used as a cytosolic fluorophore in mitochondrial permeability studies to image pore transition.
A non-fluorescent, membrane permeable probe that can be hydrolyzed to a fluorescent molecule

Especificações

Sinónimos

Especificações e pureza

for fluorescence analysis, ≥96%(HPLC)

Condições de armazenamento de armazenamento

Store at -20°C,Argon charged

Enviado em

Ice chest + Ice pads

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Grau

for Fluorescence analysis

Nota

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. For more information on AM esters please visit our AM esters FAQ page . Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Pureza

≥96%(HPLC)

Nomes e identificadores

Pubchem Sid

528776095

Sorrisos canónicos

CC(=O)OCOC(=O)CN(CC1=CC2=C(C=C1OC(=O)C)OC3=C(C24C5=CC=CC=C5C(=O)O4)C=C(C(=C3)OC(=O)C)CN(CC(=O)OCOC(=O)C)CC(=O)OCOC(=O)C)CC(=O)OCOC(=O)C

IUPAC Name

acetyloxymethyl 2-[[2-(acetyloxymethoxy)-2-oxoethyl]-[[3',6'-diacetyloxy-7'-[[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]methyl]-3-oxospiro[2-benzofuran-1,9'-xanthene]-2'-yl]methyl]amino]acetate

InChIKey

BQRGNLJZBFXNCZ-UHFFFAOYSA-N

INCHI

1S/C46H46N2O23/c1-25(49)60-21-64-41(55)17-47(18-42(56)65-22-61-26(2)50)15-31-11-35-39(13-37(31)68-29(5)53)70-40-14-38(69-30(6)54)32(12-36(40)46(35)34-10-8-7-9-33(34)45(59)71-46)16-48(19-43(57)66-23-62-27(3)51)20-44(58)67-24-63-28(4)52/h7-14H,15-24H2,1-6H3

SMILES isoméricas

CC(=O)OCOC(=O)CN(CC1=CC2=C(C=C1OC(=O)C)OC3=C(C24C5=CC=CC=C5C(=O)O4)C=C(C(=C3)OC(=O)C)CN(CC(=O)OCOC(=O)C)CC(=O)OCOC(=O)C)CC(=O)OCOC(=O)C

Peso molecular

994.87

Reaxy-Rn

10757520

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=10757520&ln=

Dados avançados

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Classe Benzopyrans
    - Subclass 1-benzopyrans
      - Level5 Dibenzopyrans
        Level6 Xanthenes

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Classe	Benzopyrans
Subclass	1-benzopyrans
Intermediate Tree Nodes	Dibenzopyrans
Direct Parent	Xanthenes
Alternative Parents	Alpha amino acid esters Diarylethers Phthalides Benzofuranones Isobenzofurans Acylals Aralkylamines Benzenoids Trialkylamines Lactones Oxacyclic compounds Acetals Carbonyl compounds Hydrocarbon derivatives Organic oxides Organopnictogen compounds
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Xanthene - Alpha-amino acid ester - Diaryl ether - Benzofuranone - Isobenzofuranone - Alpha-amino acid or derivatives - Phthalide - Isocoumaran - Isobenzofuran - Acylal - Aralkylamine - Benzenoid - Carboxylic acid ester - Lactone - Tertiary aliphatic amine - Tertiary amine - Amino acid or derivatives - Acetal - Carboxylic acid derivative - Oxacycle - Ether - Hydrocarbon derivative - Organic nitrogen compound - Carbonyl group - Organic oxide - Organopnictogen compound - Organic oxygen compound - Amine - Organooxygen compound - Organonitrogen compound - Aromatic heteropolycyclic compound
Descrição	This compound belongs to the class of organic compounds known as xanthenes. These are polycyclic aromatic compounds containing a xanthene moiety, which consists of two benzene rings joined to each other by a pyran ring.
External Descriptors	organooxygen compound
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Estrutura 3D

Alvos associados (humanos)

A498 (42825 Activities)

Lot Number	Certificate Type	Data	Item
D2613215	Certificate of Analysis	Apr 01, 2026	C131116
D2613218	Certificate of Analysis	Apr 01, 2026	C131116
F2208195	Certificate of Analysis	Dec 12, 2025	C131116
H2520002	Certificate of Analysis	Jul 24, 2025	C131116
H2520003	Certificate of Analysis	Jul 24, 2025	C131116
H2520004	Certificate of Analysis	Jul 24, 2025	C131116
I2321025	Certificate of Analysis	Jul 10, 2025	C131116
J2215198	Certificate of Analysis	Jul 18, 2024	C131116
F2208205	Certificate of Analysis	Mar 20, 2024	C131116
I2116116	Certificate of Analysis	Jul 07, 2023	C131116
J2215196	Certificate of Analysis	Oct 20, 2022	C131116

Sensibilidade	light sensitive;Moisture sensitive
Peso molecular	994.900 g/mol
XLogP3	2.900
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	25
Rotatable Bond Count	32
Exact Mass	994.249 Da
Monoisotopic Mass	994.249 Da
Topological Polar Surface Area	305.000 Å²
Heavy Atom Count	71
Formal Charge	0
Complexity	1810.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Calcein, AM - for fluorescence analysis, ≥96%(HPLC) , CAS No.148504-34-1

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